2024
DOI: 10.21203/rs.3.rs-4348054/v1
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Diagnosis of deep vein thrombosis by γ-butylbetaine and L-carnitin in plasma and urine revealed based on untargeted and targeted metabolomics

Wenjie Zeng,
Qitao Wang,
Junyu Chi
et al.

Abstract: Deep vein thrombosis (DVT) has become an important factor in the global disease burden. In this study, the differential metabolites in urine were screened by untargeted metabolomics to find metabolic markers to compensate for the poor specificity and single defect of D-dimer, γ-butyl betaine (GBB), and L-carnitine (L-CN). Ultra-high performance liquid chromatography-mass spectrometry ( UPLC-MS / MS ) was used to verify the levels of GBB and L-CN in clinical and rat blood and urine at different stages of DVT, a… Show more

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