Diagnosis of dengue: an update

Tang, Kin Fai; Ooi, Eng Eong

doi:10.1586/eri.12.76

Cited by 113 publications

(102 citation statements)

References 143 publications

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“…22,23 However, the viraemia is short so serodiagnostic tests (typically IgM Capture ELISA) are used from the end of the fi rst week onwards, ideally with demonstration of seroconversion on paired samples. Rapid tests, often combining NS1 detection with an antibody test, are also available and have a reasonable window of detection.…”

Section: Clinical Assessment and Laboratory Diagnosismentioning

confidence: 99%

Dengue: an update for clinicians working in non-endemic areas

Yacoub

Wills

2015

Clinical Medicine

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Dengue: an update for clinicians working in non-endemic areasDengue is one of the most rapidly emerging viral infections globally, with 2.5 billion people now thought to live in dengue-endemic areas. In addition, reports of travel-related and autochthonous infections are increasing in non-endemic areas. Most patients with dengue experience a selflimiting febrile illness, but a proportion develop potentially life threatening complications around the time of fever clearance, including plasma leakage occasionally leading to shock, bleeding, and organ impairment. As dengue can present with non-specifi c symptoms of fever, headache and myalgias, the potential for misdiagnosis and inappropriate management by medical staff inexperienced with the disease is a concern. This short review will outline the latest World Health Organisation disease classifi cation, potential complications, clinical assessment and management for clinicians working in non-endemic areas.

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Section: Clinical Assessment and Laboratory Diagnosismentioning

confidence: 99%

Dengue: an update for clinicians working in non-endemic areas

Yacoub

Wills

2015

Clinical Medicine

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“…Há três fases sintomáticas: uma fase febril inicial (febre de início súbito) incluindo cefaleias, vómitos, mialgias e artralgias; uma fase crítica, numa pequena proporção de doentes e por fim a recuperação espontânea. 4,6,14 Níveis isolados de proteína C reativa (PCR) podem ser, nos locais onde se tenha acesso ao teste, um biomarcador útil para diferenciar doentes com baixo risco de malária e dengue em áreas onde as doenças coexistam. 15 O tratamento é de suporte.…”

Section: Resultsunclassified

Dengue nos Países da Lusofonia: Que Ligações Epidemiológicas Poderemos Traçar?

Silvano

Abreu

2014

Acta Med Port

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Acta Med Port 2014 Jul-Aug;27(4):503-510 RESUMOIntrodução: A ocorrência recente de um conjunto de surtos de dengue em países da lusofonia previamente livres de doença, despertou-nos curiosidade quanto aos fatores concorrentes para o fenómeno e a necessidade de aprofundar conhecimentos quanto à patologia. Revemos a situação relativa à dengue nos países da lusofonia, relacionando os diferentes surtos e procurando contribuir para um melhor conhecimento do fenómeno. ABSTRACT Introduction:The recent occurrence of a number of outbreaks of dengue Portuguese speaking countries with no previous disease, aroused curiosity about the competing factors for the phenomenon and a need for better knowledge of the pathology. We review the dengue-related situation in Portuguese speaking countries, linking the various outbreaks and trying to contribute to a better understanding of the phenomenon. Material and Methods:Review of the literature on the topic and relevant information obtained from oral communications were included. Results:The outbreaks occurred between the years of 2009 and 2013 in Cabo Verde, Madeira and Angola (excluding the endemic phenomenon in Brazil), share the same vector Aedes aegypti, but are due to different viral serotypes, as shown by genotypic studies. The strong sub-notification of the disease in Africa and lack of diagnostic tools prevent a true characterization of the situation. Discussion: The hypothesis of a link between some of the outbreaks is not completely rejected. The Portuguese territory could be exposed to an increasingly high risk of dengue introduction, not only because of the proximity with these territories, but also because of the current climate changes. The main fight is, in spite of the yet utopic emergent tools, the vector control. Conclusion:A link between the outbreaks has not been proven but local preparation of healthcare professionals, creation of public health strategies and maintenance of surveillance systems are needed. More epidemiological and entomological studies are needed to characterize the real incidence of disease in Portuguese speaking countries.

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“…The use of a purified inactivated virus vaccine is currently in the planning stage for clinical testing. 25,26 A chimeric dengue vaccine was recently launched following a phase III clinical trial, and a recent study demonstrated the efficacy of that vaccine for symptomatic dengue in up to 65.6% of patients 9-16 years of age. 27,28 Clinicians must be aware of the need for early monitoring of patients and measurement of appropriate laboratory parameters to obtain an accurate diagnosis of dengue and avoid misdiagnosis as viral hepatitis in dengue-endemic countries.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Clinical Outcome of Acute Liver Failure Caused by Dengue in a Hospital for Tropical Diseases, Thailand

Mon

Nontprasert

Kittitrakul

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Acute liver failure is an atypical manifestation of dengue with a high mortality. We performed a retrospective cohort study at the Hospital for Tropical Diseases, Bangkok, Thailand. In total, 1,926 patients with serologically confirmed dengue were enrolled in the study from 2011 to 2015. Of these, six patients presented with acute liver failure, four died, and two survived. The incidence of dengue-associated acute liver failure was 0.31%. Dengue-associated acute liver failure was most common among young adults (median age, 29 years). The median duration from onset of fever to development of acute liver failure was 7.5 days. Patients with the severe stage of dengue had a higher risk of developing acute liver failure (P < 0.001). The baseline risk factors associated with the development of acute liver failure were an age of ≤ 40 years (odds ratio [OR] = 1.5, 95% confidence interval [CI] = 1.1-2.0, P < 0.05), a > 10% ratio of atypical lymphocytes (OR = 2.3, 95% CI = 1.8-3.0, P < 0.001), and a platelet count of < 50,000 mm 3 (OR = 2.8, 95% CI = 2.2-3.6, P < 0.001). The incidence of acute liver failure in patients with dengue was quite low, but its impact on morbidity, mortality, and poor clinical outcomes was significant. In summary, this study indicates that various baseline risk factors are associated with acute liver failure in patients with dengue.

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Diagnosis of dengue: an update

Cited by 113 publications

References 143 publications

Dengue: an update for clinicians working in non-endemic areas

Dengue: an update for clinicians working in non-endemic areas

Dengue nos Países da Lusofonia: Que Ligações Epidemiológicas Poderemos Traçar?

Incidence and Clinical Outcome of Acute Liver Failure Caused by Dengue in a Hospital for Tropical Diseases, Thailand

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