2010
DOI: 10.1111/j.1478-3231.2010.02314.x
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Diagnosis of different liver fibrosis characteristics by blood tests in non-alcoholic fatty liver disease

Abstract: Different characteristics of fibrosis in NAFLD can be diagnosed and quantified by blood tests with excellent accuracy.

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Cited by 47 publications
(40 citation statements)
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“…Patterns of nonlinear scaling rules define fractals, which can be measured in terms of complexity and homogeneity. Fractal geometry has been used to quantitate biological processes, such as tumor boundaries, vascular architecture, angiogenesis (8,10,23,24), bone tissue organization during regeneration (39), and liver fibrosis in rats and humans (5,12,25). Fractal analysis of collagen images provided quantitative measurements for the morphological observations.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Patterns of nonlinear scaling rules define fractals, which can be measured in terms of complexity and homogeneity. Fractal geometry has been used to quantitate biological processes, such as tumor boundaries, vascular architecture, angiogenesis (8,10,23,24), bone tissue organization during regeneration (39), and liver fibrosis in rats and humans (5,12,25). Fractal analysis of collagen images provided quantitative measurements for the morphological observations.…”
Section: Discussionmentioning
confidence: 99%
“…An indirect approach to estimate chronic pancreatic damage is the determination of elements actively involved in fibrogenesis, such as cytokines and growth factors (TGF-␤, PDFG, and monocyte chemoattractant protein) and cytofilaments overexpressed by activated PSCs (␣-SMA). Quantitative ECM assessment by morphometry has gained credit to evaluate fibrosis burden because it may better reflect ECM deposition than other parameters (5). In addition, the increased complexity of collagen in fibrosis can be quantitated by fractal analysis (12,25).…”
mentioning
confidence: 99%
“…However, the METAVIR system was also used in NAFLD and was thought to be a better reference for noninvasive panels based on blood tests. 34 Another major issue relates to whether changes in P2/MS scores correspond to changes in hepatic fibrosis over time. In the present study, the sensitivity of the P2/MS to changes in hepatic fibrosis was not examined, and thus, further studies should be undertaken to determine if changes in P2/MS can be utilized to monitor hepatic fibrosis in patients with NAFLD.…”
Section: Patient Characteristicsmentioning
confidence: 99%
“…Ils sont importants, car la normalité de la biologie standard n'élimine pas des lésions de fibrose hépatique [20,40].…”
Section: Les Tests Biologiquesunclassified