Diagnosis of Gastric Glomus Tumor by Endoscopic Ultrasound–Guided Fine Needle Aspiration Biopsy

Glomus tumor of the stomach: Cytologic diagnosis by endoscopic ultrasound‐guided fine‐needle aspiration

“…All immunohistochemical stains had adequate positive and negative controls. Table I summarizes the cytologic and immunocytochemical findings of this case and those reported previously by Vinette-Leduc and Yazdi 5 and Gu et al 12 …”

“…15,17,18 Although cytologic descriptions of such tumors are scarce, our findings are consistent with previous reports. 5,12,17,18 The differential diagnosis of gastric GT includes neuroendocrine neoplasm (i.e., carcinoid tumor), hemangiopericytoma, leiomyoblastoma (epithelioid leiomyosarcoma), angiomyoma (vascular leiomyoma), epithelioid GIST, and malignant lymphoma. 5,7,12 The differential diagnostic features of these neoplasms are compared in Table II.…”

“…Furthermore, EUS features considered suggestive of malignancy in gastrointestinal stromal tumors may be present in benign GTs. 12 These features include irregular extraluminal margins, tumor size, cystic spaces, and echogenic foci. 7,28 The GT in the present case was hypoechoic and exhibited an atypical, irregular, slightly serrated extraluminal margin on EUS.…”

“…5,12 In the case presented by Vinette-Leduc and Yazdi, 5 the FNAB sample was obtained percutaneously and the diagnosis made on the resected specimen. In our case, and that of Gu et al, 12 the diagnosis of GT was rendered from the cell block material and subsequently confirmed by the surgically resected specimen. The histological and ultrastructural characteristics of all three gastric GTs were similar (Table I).…”

“…To date, there are two other cytologic descriptions of gastric GTs, one assessed by percutaneous FNA 5 and one by EUSguided FNA. 12 We report a patient with a synchronous occurrence of GT and gastrointestinal stromal tumor (GIST) of the stomach. The preoperative diagnosis of GT was made by means of EUS-guided FNA.…”