Diagnosis of gastric intraepithelial neoplasia by narrow-band imaging and confocal laser endomicroscopy

Abstract

Higher diagnostic accuracy, sensitivity and specificity of CLE over ME-NBI indicate the feasibility of these two techniques for the efficacious diagnostic classification of gastric IN.

Meta‐analysis of confocal laser endomicroscopy for the diagnosis of gastric neoplasia and adenocarcinoma

“…Thirty‐six potentially relevant articles were selected for further review; among them, 23 was excluded due to the manuscript type ( n = 6), duplicates ( n = 4), animal study ( n = 1), insufficient data on diagnostic efficacy ( n = 2) or on GIN or gastric adenocarcinoma ( n = 10). Finally, 13 full‐text articles including 1 011 patients were enrolled in the meta‐analysis. The flowchart for study selection is shown in Fig.…”

“…All the thirteen studies were single‐center trials, with 12 published in English and one in Chinese. Seven of the studies assessed the diagnostic efficacy of CLE for GIN, whereas nine evaluated that for gastric adenocarcinoma. Pathology was the key standard when identifying lesions in all the included studies.…”

Probe-based confocal laser endomicroscopy and fluorescence-based enhanced reality for real-time assessment of intestinal microcirculation in a porcine model of sigmoid ischemia

“…The probe can be inserted through conventional endoscopes, and allows for intraoperative microscopic imaging of neoplastic and inflammatory lesions virtually throughout the entire gastrointestinal tract [8]. The clinical interest of confocal technology in the evaluation of neoplasia in Barrett's metaplasia [9], gastric [10], and colorectal [11] neoplasia seems to be increasingly confirmed.…”

Comparison between two types of confocal laser endomicroscopy in gastrointestinal tract

“…Compared with eCLE, pCLE is more flexible in respect of reaching sites such as the respiratory tract, liver and biliary tract. Both eCLE and pCLE have been shown to be reliable and comparable with or even superior to other modalities, such as magnifying endoscopy with or without narrow band imaing (NBI), standard endoscopy with biopsy and high‐definition white‐light endoscopy (HD‐WLE), in the diagnosis of Barrett's esophagus (BE), gastritis and gastric cancer and colorectal neoplasia.…”