Diagnosis of giant cell-rich bone tumors on core needle biopsy: A practical approach

Jäger, L; Johnson, Daniel N.; Sukhanova, Madina; Streich, Lukas D.; Chapa, Ajay R.; Alexiev, Borislav A.

doi:10.1016/j.prp.2022.153777

Cited by 4 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The differentiation of all giant cell-rich bone tumors has made significant steps over the past years [ 15 ▪▪ ]. Using multiple core biopsies with 16 or 18 gauge needles, it is possible to use histology, touch preparations, immunohistochemistry (IHC) and fluorescence in-situ hybridization (FISH) for diagnosis.…”

Section: Pathologymentioning

confidence: 99%

The treatment of aneurysmal bone cysts

Geloven

Sande²,

Heijden³

2022

Current Opinion in Pediatrics

View full text Add to dashboard Cite

Purpose of reviewAneurysmal bone cysts are rare, locally aggressive bone tumors. Optimal treatment of ABCs is still matter of debate as therapies including sclerotherapy, selective arterial embolization and systemic treatment with denosumab are increasingly utilized, in addition to or instead of traditional curettage. The purpose of this review is to discuss current concepts and difficulties in diagnosing and treating primary ABCs, based on latest available literature.Recent findingsIn diagnostics, multiple new fusion partners of USP-6 have been described on next-generation sequencing specifically for primary ABCs. In a recent systematic review, failure rates of percutaneous injections and surgery were comparable. In a literature review, the use of denosumab seemed effective but resulted in multiple cases of severe hypercalcemia in children.SummaryAccurately diagnosing primary ABC is crucial for treatment decisions. Curettage remains a valid treatment option, especially with adjuvant burring, autogenous bone grafting and phenolization. Percutaneous sclerotherapy represents a solid alternative to surgery, with polidocanol showing good results in larger studies. Systematic therapy with denosumab exhibits favorable results but should be reserved in the pediatric population for unresectable lesions, as it may result in severe hypercalcemia in children. When selecting a treatment option, localization, stability and safety should be considered.

show abstract

Section: Pathologymentioning

confidence: 99%

The treatment of aneurysmal bone cysts

Geloven

Sande²,

Heijden³

2022

Current Opinion in Pediatrics

View full text Add to dashboard Cite

show abstract

“…Morphological features alone rarely suffice and clinical data or molecular analysis is required. [1][2][3] The use of genetic testing in routine practice is helpful only in select cases to date, with ABC being one of them.…”

Section: Introductionmentioning

confidence: 99%

Novel and unusualUSP6fusion partners in aneurysmal bone cyst and their role in pathogenesis and histopathological evaluation of this disease

Balko,

Golas,

Kaspar

et al. 2024

J Clin Pathol

View full text Add to dashboard Cite

AimsThe purpose of this study is to report novel and unusualUSP6fusion partners in aneurysmal bone cysts (ABCs). These findings may be useful in routine diagnostics as well as in studying the biology ofUSP6-related disorders.MethodsA cohort of seven patients diagnosed with ABC examined between 2014 and 2023 at Motol University Hospital in Prague was included into this retrospective non-randomised study. All cases were analysed using histopathological evaluation, immunohistochemistry and Anchored multiplex RNA methods. Demographic characteristics and clinical data were also analysed.ResultsWe identified two novel (ZFXandIP6K2), three unusual (MEF2A, EIF1andCOL1A2) and two common (CDH11) fusion partners withUSP6gene among all seven cases of ABC.ConclusionsCases in our study were diagnosed as ABCs due to characteristic clinical and morphological presentation. However, not all cases are as self-evident, and molecular testing is necessary. The identification of these gene alterations can be useful in distinction between true ABC and ABC-like changes among many benign and malignant bone tumours.

show abstract

Bone

Lajara

2023

Non-Neoplastic Cytology

View full text Add to dashboard Cite

Diagnosis of giant cell-rich bone tumors on core needle biopsy: A practical approach

Cited by 4 publications

References 33 publications

The treatment of aneurysmal bone cysts

The treatment of aneurysmal bone cysts

Novel and unusualUSP6fusion partners in aneurysmal bone cyst and their role in pathogenesis and histopathological evaluation of this disease

Bone

Contact Info

Product

Resources

About