Diagnosis of Glioma Molecular Markers by Terahertz Technologies

Черкасова, О. П.; Peng, Yan; Konnikova, Maria; Kistenev, Yuri; Shi, Chenjun; Vrazhnov, Denis A.; Shevelev, Oleg B.; Zavjalov, E. L.; Kuznetsov, Sergei A.; Shkurinov, A. P.

doi:10.3390/photonics8010022

Cited by 27 publications

(17 citation statements)

References 204 publications

(243 reference statements)

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“…Glioma is one of the most common tumors in the central nervous system [1]. Its identification at the earliest stages is a medical task of primary importance [2]. Among molecular biomarkers of gliomas, the mutated enzyme of isocitrate dehydrogenase 1/2 (IDH1/IDH2) was recently identified [3].…”

Section: Introductionmentioning

confidence: 99%

Terahertz technology in diagnosis of glioma molecular markers

Kuznetsov

Konnikova

Heinz

et al. 2022

J. Phys.: Conf. Ser.

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Gliomas are invasive brain tumors with high rates of recurrence and mortality. It has been shown that specific markers for glioma’s differential diagnostics are enantiomers of 2-hydroxyglutarate (L-2HG and D-2HG) in brain tissues and blood. These isomers have unique absorption peaks originating from vibrational and rotational transitions in their molecules. In particular, the peaks centered at 1.337 THz and 1.695 THz correspond to L-2HG and D-2HG isomers, respectively. The goal of this work is to develop highly efficient frequency-selective sensors for L-2HG and D-2HG isomers using the effect of nanoantenna-assisted plasmonic enhancement of THz absorption. Such an approach provides a noticeable increase in detection sensitivity versus direct non-resonant methods. In this paper, we present the numerical results of the design optimization for L-2HG and D-2HG sensors based on Si/SiO2-wafer-backed arrays of golden nanoantennas of linear geometry. The optimal structural parameters of the arrays found through integral averaging of the square of the surface electric field over an array unit cell are recommended for further nanolithographic fabrication of this kind of THz sensor.

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Section: Introductionmentioning

confidence: 99%

Terahertz technology in diagnosis of glioma molecular markers

Kuznetsov

Konnikova

Heinz

et al. 2022

J. Phys.: Conf. Ser.

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“…An increasing interest in biomedical applications of terahertz (THz) radiation, featuring the frequencies of 0.1 to 3.0 THz, the free-space wavelengths of

, or the quantum energies of

to 10 meV (see Fig. 1 ), has been observed during the past few decades, 1 – 5 driven by rapid progress in THz technology. 6 , 7 Numerous research papers demonstrate the potential of THz technology in label-free early noninvasive, least-invasive, and intraoperative diagnosis of malignant and benign neoplasms with different nosologies and localizations, 3 , 4 , 8 – 18 sensing of glycated tissues and blood in the context of diabetes diagnosis, 1 , 19 – 21 determining the degree of traumatic injuries, 22 – 25 hydration levels, 26 – 29 and viability 30 of tissues.…”

Section: Introductionmentioning

confidence: 99%

Cellular effects of terahertz waves

et al. 2021

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. Significance: An increasing interest in the area of biological effects at exposure of tissues and cells to the terahertz (THz) radiation is driven by a rapid progress in THz biophotonics, observed during the past decades. Despite the attractiveness of THz technology for medical diagnosis and therapy, there is still quite limited knowledge about safe limits of THz exposure. Different modes of THz exposure of tissues and cells, including continuous-wave versus pulsed radiation, various powers, and number and duration of exposure cycles, ought to be systematically studied. Aim: We provide an overview of recent research results in the area of biological effects at exposure of tissues and cells to THz waves. Approach: We start with a brief overview of general features of the THz-wave–tissue interactions, as well as modern THz emitters, with an emphasis on those that are reliable for studying the biological effects of THz waves. Then, we consider three levels of biological system organization, at which the exposure effects are considered: (i) solutions of biological molecules; (ii) cultures of cells, individual cells, and cell structures; and (iii) entire organs or organisms; special attention is devoted to the cellular level. We distinguish thermal and nonthermal mechanisms of THz-wave–cell interactions and discuss a problem of adequate estimation of the THz biological effects’ specificity. The problem of experimental data reproducibility, caused by rareness of the THz experimental setups and an absence of unitary protocols, is also considered. Results: The summarized data demonstrate the current stage of the research activity and knowledge about the THz exposure on living objects. Conclusions: This review helps the biomedical optics community to summarize up-to-date knowledge in the area of cell exposure to THz radiation, and paves the ways for the development of THz safety standards and THz therapeutic applications.

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“…The assessment of all these biochemical compounds makes it possible to differentiate between normal and pathological tissues of the brain, as well as between different stages of a pathological process relying on the THz spectra and images. All these factors, along with the biochemical and structural neuronal and glial features, including microscopic variations of tissue properties (tissue microenvironments 34 , cellular and tissue morphology 35 , biomolecules 36 and their large-scale fluctuations 25,37 ), make the brain an exciting subject for study using THz technology 10,38,39 .…”

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confidence: 99%

Terahertz technology in intraoperative neurodiagnostics: A review

Chernomyrdin¹,

Musina²,

Никитин³

et al. 2023

OEA

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Terahertz (THz) technology offers novel opportunities in biology and medicine, thanks to the unique features of THzwave interactions with tissues and cells. Among them, we particularly notice strong sensitivity of THz waves to the tissue water, as a medium for biochemical reactions and a main endogenous marker for THz spectroscopy and imaging. Tissues of the brain have an exceptionally high content of water. This factor, along with the features of the structural organization and biochemistry of neuronal and glial tissues, makes the brain an exciting subject to study in the THz range. In this paper, progress and prospects of THz technology in neurodiagnostics is overviewed, including diagnosis of neurodegenerative disease, myelin deficit, tumors of the central nervous system (with an emphasis on brain gliomas), and traumatic brain injuries. Fundamental and applied challenges in study of the THz-wave -brain tissue interactions and development of the THz biomedical tools and systems for neurodiagnostics are discussed.

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Diagnosis of Glioma Molecular Markers by Terahertz Technologies

Cited by 27 publications

References 204 publications

Terahertz technology in diagnosis of glioma molecular markers

Terahertz technology in diagnosis of glioma molecular markers

Cellular effects of terahertz waves

Terahertz technology in intraoperative neurodiagnostics: A review

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