Diagnosis of hantavirus infection in humans and rodents in Ribeirão Preto, State of São Paulo, Brazil

Figueiredo, Glauciane Garcia de; Borges, Alessandra Abel; Campos, Geraldo Maia; Machado, Alex Martins; Saggioro, Fabiano Pinto; Júnior, Gilberto dos Santos Sabino; Badra, Soraya Jabur; Ortiz, Alberto Anastacio Amarilla; Figueiredo, Luíz Tadeu Moraes

doi:10.1590/s0037-86822010000400002

Cited by 26 publications

(17 citation statements)

References 24 publications

(34 reference statements)

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“…This fatality ratio is lower than others reported in previous studies in the region of Ribeirão Preto, which was approximately 50% (Campos et al 2009, Figueiredo et al 2009bFigueiredo et al 2010. ARAV, the causative of HCPS in the region of Ribeirão Preto is, probably, the most virulent among all Brazilian hantaviruses (Figueiredo et al 2009b).…”

Section: Discussioncontrasting

confidence: 59%

Hantavirus Cardiopulmonary Syndrome in Ribeirão Preto, Brazil, 2010-2011

Figueiredo¹,

Pádua²,

Júnior³

et al. 2011

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Cardiopulmonary Syndrome (HCPS) is a severe disease caused by Hantaviruses. In the present study, we have analyzed sera of 62 HCPS suspected cases from the region of Ribeirão Preto, São Paulo, in the period of 2010-2011. Clinical samples of twelve patients were positive, based on both RT-PCR and IgM-ELISA. Hantavirus-infected patients included 8 males and 4 females, 16-57 years old, 3 of whom were rural workers (25%) and one of them related direct contact with wild rodents. The majority of the other patients (75%) lived in the periphery of cities and reported the presence of rodents in their homes. The case fatality ratio of these 12 HCPS cases was 41.6%. Our results confirm that hantaviruses are endemic, with occurrence of HCPS and fatalities, every year, in the region of Ribeirão Preto. More educational and preventive measures are necessary in order to prevent human infections by hantavirus in the region, and other parts of Brazil.

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Section: Discussioncontrasting

confidence: 59%

Hantavirus Cardiopulmonary Syndrome in Ribeirão Preto, Brazil, 2010-2011

Figueiredo¹,

Pádua²,

Júnior³

et al. 2011

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“…The levels of IgG are detectable throughout the life of the individual, allowing studies about the prevalence of HPS [36]. Diagnosis can also be done by PCR techniques, already performed in research centers in Brazil, but routine use of this technique is limited due to its costs [37,38].…”

Section: Diagnosismentioning

confidence: 99%

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Pinto

Hamidad

Filho

et al. 2014

J Infect Dev Ctries

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Hantavirus infection is transmitted to humans by wild rodents and the most common clinical form in Brazil is the Hantavirus Pulmonary Syndrome (HPS). The first serological evidence of the disease was identified in 1990, in Recife, Pernambuco State, and later in 1993 in Juquitiba, State of São Paulo. Since then there has been a progressive increase in case notification in all regions of the country. The clinical aspects of the disease in Brazil are characterized by a prodromal phase, with nonspecific signs and symptoms of an acute febrile illness. After about three days, respiratory distress develops, accompanied by dry cough that turns progressively productive, evolving to dyspnea and respiratory failure with cardiogenic shock. Although the majority of patients receive hospital care in intensive care therapy units, case-fatality rate in Brazil ranges from 33% to 100% depending on the region. Besides it has to be added the problem of differential diagnosis with other prevalent diseases in the country, like dengue and leptospirosis. Questions about the impact of uncontrolled urbanization and other environmental changes caused by human action have been raised. Due to increasing incidence and high case-fatality, there is an urge to respond to such questions to recommend preventative measures. This article aims to review the main acquisitions in clinical and epidemiological knowledge about HPS in Brazil in the last twenty years.

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“…Between 1993-2010, more than 1,300 cases of HPCS have been reported in all the Brazilian regions, distributed throughout 14 states (MS/ SVS/DVE 2010). Five hantaviruses have been reported to cause hantavirus pulmonary and cardiovascular syndrome (HPCS) in Brazilian patients: Anajatuba, Araraquara, Castelo dos Sonhos, Juquitiba and Laguna Negra-like (Figueiredo et al 2010). Hantavirus infection in Brazil is predominantly related to agricultural activity and a common manner of contracting this infection, especially in remote small towns, is through the cleaning of rural grain storage buildings.…”

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confidence: 99%