Diagnosis of hepatitis B infections and monitoring of treatment

Badur, Selim; Akgün, Ayşegül

doi:10.1016/s1386-6532(01)00147-0

Cited by 46 publications

(30 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Detection of HBsAg in blood is a diagnostic marker for infection with HBV and in blood banks screening for HBsAg is carried out routinely to detect HBV infection. Occult HBV infection is defined as the presence of HBV-DNA in blood or liver tissues in patients negative for HBsAg but who may or may not be positive for HBV antibodies [4,5]. It is possible that donors with occult HBV infection, who lack detectable HBsAg whose exposure to HBV infection indicated by positive anti-HBc antibodies against HBV core antigen and HBV DNA are a potential source of HBV infection [6].…”

Section: Introductionmentioning

confidence: 99%

Anti-HBc and HBV-DNA detection in blood donors negative for hepatitis B virus surface antigen

Badrawy¹,

Bakry²

2013

AJMB

View full text Add to dashboard Cite

Occult HBV infection is defined as the presence of hepatitis B virus (HBV) DNA in blood or liver tissues in patients negative for Hepatitis B surface Antigen (HBsAg). Those patients may or may not be positive for HBV antibodies. The objective of this study is to determine the presence or absence of HBV DNA in the serum samples from HBsAg negative blood donors. In addition we aimed to assess the magnitude of occult HBV infection and to reduce the risk of HBV infection. Over a period of one year a total of 7340 blood units were collected at blood transfusion center in our locality for the prevalence of HBV infection and 180 HBsAg negative blood specimens were randomly selected for anti-HBcIgM, anti-HBs antibody and HBV DNA. Ninety seven out of 7340 collected blood units were positive for HbsAg (1.3%). The randomly selected 180 tested donors revealed 7 (3.8%) positive for antiHBc IgM and 34 (18.8%) were positive for anti-HBs antibodies. Four out of 7 positive for anti-HBc IgM were also positive for anti-HBs and 2/180 (1.1%) specimens were positive for HBV DNA by PCR. Anti-HBc antibody should be tested routinely at any blood transfusion center and if they were positive regardless of anti-HBs titer, the blood should be discarded. Also HBV DNA is preferable to be performed to all blood donors to present completely safe blood transfusion.

show abstract

Section: Introductionmentioning

confidence: 99%

Anti-HBc and HBV-DNA detection in blood donors negative for hepatitis B virus surface antigen

Badrawy¹,

Bakry²

2013

AJMB

View full text Add to dashboard Cite

show abstract

“…The risk of transmitting hepatitis through transfusions of blood and blood products has been known since 1950 [23,24]. Usually, HBV infection occurs when an individual receives blood with HBsAg and anti-HBc (Hepatitis B core antibody) in the serum or plasma of donors [25,26]. In Saudi Arabia, the prevalence of HBsAg in blood donors was found to range from 2.7% to 9.8% [9,11,12].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and predictors of hepatitis B in Jeddah City, Saudi Arabia: a population-based seroprevalence study

Al‐Raddadi

Dashash

Alghamdi

et al. 2016

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Despite solid preventive strategies to reduce the risk of hepatitis B virus (HBV) infection, recent reports about its prevalence and predictors are lacking in several Saudi cities at the community level. This study aimed to assess the seroprevalence of HBV and to identify the most important predictors among the Saudi population in Jeddah city, Saudi Arabia. Methodology: A cross-sectional study was conducted among 5,584 Saudi people attending primary health-care centers in Jeddah city during 2012/2013. Sociodemographic and hepatitis-related data were collected. HBV was diagnosed by ELISA test. The seroprevalence of HBV was estimated, and appropriate statistical analyses were performed, including univariate and multivariable regression analyses. Results: The seroprevalence of HBV was 2.2% (95% CI = 1.82-2.58) in the studied participants. The prevalence was higher among nongovernmental workers (3.5%), male participants (3.4%) and those aged ≥ 25 years (2.4%). The most important predictors for increasing the risk of HBV in this study were HBV contacts, male sex, history of dental procedures and blood transfusion. The significant positive risks associated with these predictors were 3.3, 2.5, 2.0 and 1.65, respectively. HBV vaccination, on the other hand, was associated with a significant risk reduction of 88% (OR = 0.12; 95% CI = 0.03-0.51). Conclusions: The seroprevalence of HBV was relatively low among the Saudi population in Jeddah city reflecting the actions taken by health authorities to control HBV infection. However, more efforts, particularly in relation to health education programmes, strict control of blood banks and dental clinics, are still needed.

show abstract

“…Hepatitis B surface antigen (HBsAg) can be found in filamentous or spherical surface antigen particles in addition to virions. It is generally accepted that the diagnosis of infection by hepatitis B virus (HBV) is based on the presence of the HBsAg in the blood, since that it can generally be detected while still in the incubation period [2]. Hence, developing rapid and sensitive methods for measuring HBsAg has great clinical significance in the clinical diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Disposable immunoassay for hepatitis B surface antigen based on a graphene paste electrode functionalized with gold nanoparticles and a Nafion-cysteine conjugate

Huang

Liu

et al. 2012

Microchim Acta

View full text Add to dashboard Cite

Diagnosis of hepatitis B infections and monitoring of treatment

Cited by 46 publications

References 29 publications

Anti-HBc and HBV-DNA detection in blood donors negative for hepatitis B virus surface antigen

Anti-HBc and HBV-DNA detection in blood donors negative for hepatitis B virus surface antigen

Prevalence and predictors of hepatitis B in Jeddah City, Saudi Arabia: a population-based seroprevalence study

Disposable immunoassay for hepatitis B surface antigen based on a graphene paste electrode functionalized with gold nanoparticles and a Nafion-cysteine conjugate

Contact Info

Product

Resources

About