Diagnosis of <i>Helicobacter pylori</i> Infection by Means of Reduced‐Dose <sup>13</sup>C‐Urea Breath Test and Early Sampling of Exhaled Breath

Pacheco, Sylmara L. M.; Ogata, Silvio Kazuo; Machado, Rodrigo Strehl; Patrı́cio, Francy Reis da Silva; Pardo, Mário Luís E.; Kawakami, Elisabete

doi:10.1097/mpg.0b013e3182a02608

Cited by 23 publications

(17 citation statements)

References 23 publications

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“…Yang et al from Korea, indicated sensitivity and specificity of 97.1% and 96.4% correspondingly (30) . In another study on 129 children age 2.1-19 years, sensitivity and specificity of 13 C-UBT were more than 90% (25) . In the study by Kawakemi et al on 75 children aged 6 months to 8 years, sensitivity and specificity of UBT were 96.8% and 93.2% respectively (17) .…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

Honar

Minazadeh

Shakibazad

et al. 2016

Arq. Gastroenterol.

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-Background -Helicobacter pylori infection is the gram negative bacillus with the close association with chronic antral gastritis. Objective -In this study, we evaluate the accuracy of urea breath test (UBT) with carbon isotope 13 in comparison with histopathology of gastric antrum for detection of H. pylori infection in children with dyspepsia. Methods -This cross-sectional study was performed at specialized laboratory of Shiraz Gastroenterohepatology Research Center and Nemazee Hospital, Iran, during a 12-months period. This study investigated the sensitivity, specificity, and positive and negative predictive values of UBT in comparison with biopsy-based tests. We included a consecutive selection of 60 children who fulfilled Rome III criteria for dyspepsia. All children were referred for performing UBT with carbon isotope 13 (C13) as well as endoscopy. Biopsies were taken from antrum of stomach and duodenum. The pathologic diagnosis was considered as the standard test. Results -The mean age of the participants was 10.1±2.6 (range 7-17 years). From our total 60 patients, 28 (46.7%) had positive UBT results and 32 (53.3%) had negative UBT results. Pathologic report of 16 (57.1%) out of 28 patients who had positive UBT were positive for H. pylori and 12 (42.9%) ones were negative. Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Conclusion -Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Another multicenter study from our country is recommended. HEADINGS -Child health. Dyspepsia. Gastritis. Helicobacter infections. Peptic ulcer. Urease.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

Honar

Minazadeh

Shakibazad

et al. 2016

Arq. Gastroenterol.

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“…However, biopsy is an invasive and tedious procedure, requiring endoscopy that is prone to missing small lesions and making the patient uncomfortable. Noninvasive tests have also been developed, such as the urea breath test (UBT)910, IgG serology11, immunoblot12 and antigen stool detection13. UBT, based on the activity of urease of H. pylori , is the most sensitive and noninvasive test among these traditional methods.…”

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confidence: 99%

In situ targeted MRI detection of Helicobacter pylori with stable magnetic graphitic nanocapsules

Ding

et al. 2017

Nat Commun

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Helicobacter pylori infection is implicated in the aetiology of many diseases. Despite numerous studies, a painless, fast and direct method for the in situ detection of H. pylori remains a challenge, mainly due to the strong acidic/enzymatic environment of the gastric mucosa. Herein, we report the use of stable magnetic graphitic nanocapsules (MGNs), for in situ targeted magnetic resonance imaging (MRI) detection of H. pylori. Several layers of graphene as the shell effectively protect the magnetic core from corrosion while retaining the superior contrast effect for MRI in the gastric environment. Boronic-polyethylene glycol molecules were synthesized and modified on the MGN surface for targeted MRI detection. In a mouse model of H. pylori-induced infection, H. pylori was specifically detected through both T2-weighted MR imaging and Raman gastric mucosa imaging using functionalized MGNs. These results indicated that enhancement of MRI using MGNs may be a promising diagnostic and bioimaging platform for very harsh conditions.

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“…The cross‐sectional studies on H. pylori infection in symptomatic children as detected by histology are summarized in Figure [references: ] . H. pylori prevalence estimates vary greatly (3%‐76%) with an overall random‐effects regression model estimate of 39% (95% CI: 35%‐43%).…”

Section: Resultsmentioning

confidence: 99%

Review: Prevalence and dynamics of Helicobacter pylori infection during childhood

et al. 2017

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The prevalence of H. pylori infection varied widely in the studies included here; nevertheless, model estimates by detection type were similar, suggesting that overall, one-third of children worldwide are or have been infected. The few cohort and longitudinal studies available show variability, but most studies, show infection rates over 30%. Rather surprisingly, overall infection prevalence in symptomatic children was only slightly higher, around 40%. Studies including only one positive stool sample should be interpreted with caution as spontaneous clearance can occur.

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Diagnosis of Helicobacter pylori Infection by Means of Reduced‐Dose ¹³C‐Urea Breath Test and Early Sampling of Exhaled Breath

Abstract: Low-dose ¹³C-UBT with early sampling is accurate for diagnosing H pylori infection in children and adolescents.

Cited by 23 publications

References 23 publications

Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

In situ targeted MRI detection of Helicobacter pylori with stable magnetic graphitic nanocapsules

Review: Prevalence and dynamics of Helicobacter pylori infection during childhood

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Diagnosis of Helicobacter pylori Infection by Means of Reduced‐Dose 13C‐Urea Breath Test and Early Sampling of Exhaled Breath

Abstract: Low-dose ¹³C-UBT with early sampling is accurate for diagnosing H pylori infection in children and adolescents.

Cited by 23 publications

References 23 publications

Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

In situ targeted MRI detection of Helicobacter pylori with stable magnetic graphitic nanocapsules

Review: Prevalence and dynamics of Helicobacter pylori infection during childhood

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Diagnosis of Helicobacter pylori Infection by Means of Reduced‐Dose ¹³C‐Urea Breath Test and Early Sampling of Exhaled Breath