Diagnosis of intracranial hemorrhagic lesions: comparison between 3D-SWAN (3D T2*-weighted imaging with multi-echo acquisition) and 2D-T2*-weighted imaging

Hayashida, Yoshiko; Kakeda, Shingo; Hiai, Yasuhiro; Ide, Satoshi; Ogasawara, Atsushi; Ooki, Hodaka; Watanabe, Keita; Nishimura, Joji; Ohnari, Norihiro; Korogi, Yukunori

doi:10.1177/0284185113495836

Cited by 16 publications

(10 citation statements)

References 11 publications

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“…Thus, it is used for the detection of vascular malformations, 10 brain infarctions, 11 cerebral hemorrhage, 9 diffuse axonal injury, 8 and traumatic brain injury. 9,12 In cases of neoplasia, SWI allows differentiation between neovascularization and intratumoral hemorrhage. Due to its excellent contrast resolution, and thin slice thickness and small interslice gap, neovascular venous structures containing deoxyhemoglobin can be visualized.…”

Section: Introductionmentioning

confidence: 99%

Susceptibility weighted imaging at 1.5 Tesla magnetic resonance imaging in dogs: Comparison with T2*‐weighted gradient echo sequence and its clinical indications

Weston

Morales²,

Dunning

et al. 2020

Vet Radiology Ultrasound

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Susceptibility weighted imaging (SWI) is a high resolution, fully velocity‐compensated, three‐dimensional gradient echo (GE) MRI technique. In humans, SWI has been reported to be more sensitive than T2*‐weighted GE sequences in the identification of both intracranial hemorrhage and intra‐vascular deoxyhemoglobin. However, published clinical studies comparing SWI to T2*‐weighted GE sequences in dogs are currently lacking. The aim of this retrospective, observational study was to compare SWI and T2*‐weighted GE sequences in a group of dogs with intracranial disease. Medical records were searched for dogs that underwent a brain MRI examination that included T2*‐weighted GE and SWI sequences. The presence and appearance of non‐vascular and vascular signal voids observed on T2*‐weighted GE and SWI were compared. Thirty‐two dogs were included with the following diagnoses: presumed and confirmed intracranial neoplasia (27), cerebrovascular accidents (3), and trauma (2). Hemorrhagic lesions were significantly more conspicuous on SWI than T2*‐weighted GE sequences (P < .0001). Venous structures were well defined in all SWI sequences, and poorly defined in all dogs on T2*‐weighted GE. Susceptibility weighted imaging enabled identification of vascular abnormalities in 30 of 32 (93.8%) dogs, including: neovascularization in 19 of 32 (59.4%) dogs, displacement of perilesional veins in five of 32 (15.6%) dogs, and apparent dilation of perilesional veins in 10 of 32 (31.3%) dogs. Presence of neovascularization was significantly associated with T1‐weighted post‐contrast enhancement (P = .0184). Hemorrhagic lesions and venous structures were more conspicuous on SWI compared to T2*‐weighted GE sequences. Authors recommend adding SWI to standard brain protocols in dogs for detecting hemorrhage and identifying venous abnormalities for lesion characterization.

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Section: Introductionmentioning

confidence: 99%

Susceptibility weighted imaging at 1.5 Tesla magnetic resonance imaging in dogs: Comparison with T2*‐weighted gradient echo sequence and its clinical indications

Weston

Morales²,

Dunning

et al. 2020

Vet Radiology Ultrasound

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“…As with SWI, SWAN focuses on intracerebral small vessels for identifying cerebral hemorrhage and calcifications ( 68 ) by visualizing measurable changes in cerebral veins due to hypoxia ( 69 ). It is particularly useful in visualizating micro-hemorrhages and lesions near the skull base ( 70 ), and has contributed to a proposed MRI grading scale ( 71 , 72 ). Application of susceptibility-weighted imaging mapping (SWIM) for quantitative assessment ( 67 ) of venous blood oxygenation in the acute stage of mTBI has shown an excess of oxygen in impacted areas that may reflect a neuroprotective response following the injury ( 73 ).…”

Section: Neuroimagingmentioning

confidence: 99%

Functional, Structural, and Neurotoxicity Biomarkers in Integrative Assessment of Concussions

et al. 2016

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Concussion is a complex, heterogeneous process affecting the brain. Accurate assessment and diagnosis and appropriate management of concussion are essential to ensure that athletes do not prematurely return to play or others to work or active military duty, risking re-injury. To date, clinical diagnosis relies primarily on evaluating subjects for functional impairment using instruments that include neurocognitive testing, subjective symptom report, and neurobehavioral assessments, such as balance and vestibular-ocular reflex testing. Structural biomarkers, defined as advanced neuroimaging techniques and biomarkers assessing neurotoxicity and immunoexcitotoxicity, may complement the use of functional biomarkers. We hypothesize that neurotoxicity AMPA, NMDA, and kainite receptor biomarkers might be utilized as a part of comprehensive approach to concussion evaluations, with the goal of increasing diagnostic accuracy and facilitating treatment planning and prognostic assessment.

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“…However, the diagnosis of SS still lacks confidence in both conventional MRI and DWI. Susceptibility-weighted imaging (SWI) is a technique that consists of both magnitude and phase images from a high-resolution, three-dimensional and fully velocity-compensated gradient-echo images [11][12][13]. As a result, SWI maximizes the sensitivity to magnetic susceptibility effects and has been used to visualize small cerebral veins and blood products based on the magnetic properties of tissues.…”

Section: Introductionmentioning

confidence: 99%

Susceptibility-weighted MR imaging in the diagnosis of superficial siderosis of the central nervous system: what can it add to conventional MR imaging and diffusion-weighted MR imaging

Xiao

Huang

et al. 2020

Chin J Acad Radiol

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Objectives To systematically investigate the capability of susceptibility-weighted imaging (SWI) in the assessment of SS by comparisons with conventional MRI and DWI. Methods From retrospective data, 21 patients with SS who underwent conventional MRI, DWI and SWI sequences were selected. The number of microbleeds in the brain parenchyma and extent of the lesions identified between the three techniques were compared using one-factor analysis of variance. Results Susceptibility-weighted imaging showed excellent intra-and interobserver agreements in the assessment of SS, and also detected a larger number of SS with wider distribution in the surface of the brain and more cerebral microbleeds in brain parenchyma compared to the conventional MR sequences and DWI sequence (all p < 0.05). Conclusion Susceptibility-weighted imaging can provide excellent intra-and interobserver agreements and sensitive imaging biomarkers for detecting the presence of SS, especially the microbleeds in brain parenchyma, thus having the potential to improve early detection and progression monitoring of this disease.

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Diagnosis of intracranial hemorrhagic lesions: comparison between 3D-SWAN (3D T2-weighted imaging with multi-echo acquisition) and 2D-T2-weighted imaging

Abstract: SWAN is equal or superior to standard T2-WI for the diagnosis of various cerebral hemorrhagic lesions. Because its acquisition time is reasonable it may replace T2-WI.

Cited by 16 publications

References 11 publications

Susceptibility weighted imaging at 1.5 Tesla magnetic resonance imaging in dogs: Comparison with T2*‐weighted gradient echo sequence and its clinical indications

Susceptibility weighted imaging at 1.5 Tesla magnetic resonance imaging in dogs: Comparison with T2*‐weighted gradient echo sequence and its clinical indications

Functional, Structural, and Neurotoxicity Biomarkers in Integrative Assessment of Concussions

Susceptibility-weighted MR imaging in the diagnosis of superficial siderosis of the central nervous system: what can it add to conventional MR imaging and diffusion-weighted MR imaging

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Diagnosis of intracranial hemorrhagic lesions: comparison between 3D-SWAN (3D T2*-weighted imaging with multi-echo acquisition) and 2D-T2*-weighted imaging

Abstract: SWAN is equal or superior to standard T2*-WI for the diagnosis of various cerebral hemorrhagic lesions. Because its acquisition time is reasonable it may replace T2*-WI.

Cited by 16 publications

References 11 publications

Susceptibility weighted imaging at 1.5 Tesla magnetic resonance imaging in dogs: Comparison with T2*‐weighted gradient echo sequence and its clinical indications

Susceptibility weighted imaging at 1.5 Tesla magnetic resonance imaging in dogs: Comparison with T2*‐weighted gradient echo sequence and its clinical indications

Functional, Structural, and Neurotoxicity Biomarkers in Integrative Assessment of Concussions

Susceptibility-weighted MR imaging in the diagnosis of superficial siderosis of the central nervous system: what can it add to conventional MR imaging and diffusion-weighted MR imaging

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Product

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Diagnosis of intracranial hemorrhagic lesions: comparison between 3D-SWAN (3D T2-weighted imaging with multi-echo acquisition) and 2D-T2-weighted imaging

Abstract: SWAN is equal or superior to standard T2-WI for the diagnosis of various cerebral hemorrhagic lesions. Because its acquisition time is reasonable it may replace T2-WI.