Diagnosis of intracranial lymphoma in patients with AIDS: value of 201TI single-photon emission computed tomography.

O’Malley, Janis P.; Ziessman, H.A.; Kumar, P.; Harkness, Beth A.; Tall, Jonathan; Pierce, Phillip F.

doi:10.2214/ajr.163.2.8037042

Cited by 63 publications

(21 citation statements)

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“…Single-photon-emission computed tomography imaging using thallium-201 as the tracer in patients with PML has been reported, but the results were inconsistent (82,83).…”

Section: Neuroimaging In Pmlmentioning

confidence: 99%

Progressive multifocal leukoencephalopathy in rheumatic diseases: Evolving clinical and pathologic patterns of disease

Calabrese¹,

Molloy²,

Huang³

et al. 2007

Arthritis & Rheumatism

169

102

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“…Single-photon-emission computed tomography imaging using thallium-201 as the tracer in patients with PML has been reported, but the results were inconsistent (82,83).…”

Section: Neuroimaging In Pmlmentioning

confidence: 99%

Progressive multifocal leukoencephalopathy in rheumatic diseases: Evolving clinical and pathologic patterns of disease

Calabrese¹,

Molloy²,

Huang³

et al. 2007

Arthritis & Rheumatism

169

102

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“…Several studies have evaluated the utility of thallium-201 SPECT in distinguishing cerebral lymphoma from toxoplasmic encephalitis in patients with AIDS (table 5) [119,[133][134][135][136][137][138][139][140][141][142][143][144]. Although initial studies of thallium-201 SPECT showed a high sensitivity and specificity for the diagnosis of CNS lymphoma in patients with AIDS [133,134], subsequent reports reported lower diagnostic accuracy.…”

Section: Thallium-201 Single-photon Emission Ct (Spect)mentioning

confidence: 99%

“…Although initial studies of thallium-201 SPECT showed a high sensitivity and specificity for the diagnosis of CNS lymphoma in patients with AIDS [133,134], subsequent reports reported lower diagnostic accuracy. A compilation of the published studies revealed a mean sensitivity and specificity of 92% and 89%, respectively [119, 135-139, 141, 144-147].…”

Section: Thallium-201 Single-photon Emission Ct (Spect)mentioning

confidence: 99%

Focal Neurological Disease in Patients with Acquired Immunodeficiency Syndrome

Skiest

2002

Clinical Infectious Diseases

142

128

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Focal neurological disease in patients with acquired immunodeficiency syndrome may be caused by various opportunistic pathogens and malignancies, including Toxoplasma gondii, progressive multifocal leukoencephalopathy (PML), cytomegalovirus (CMV), and Epstein-Barr virus-related primary central nervous system (CNS) lymphoma. Diagnosis may be difficult, because the findings of lumbar puncture, computed tomography (CT), and magnetic resonance imaging are relatively nonspecific. Newer techniques have led to improved diagnostic accuracy of these conditions. Polymerase chain reaction (PCR) of cerebrospinal fluid specimens is useful for diagnosis of PML, CNS lymphoma, and CMV encephalitis. Recent studies have indicated the diagnostic utility of new neuroimaging techniques, such as single-photon emission CT and positron emission tomography. The combination of PCR and neuroimaging techniques may obviate the need for brain biopsy in selected cases. However, stereotactic brain biopsy, which is associated with relatively low morbidity rates, remains the reference standard for diagnosis. Highly active antiretroviral therapy has improved the prognosis of several focal CNS processes, most notably toxoplasmosis, PML, and CMV encephalitis.

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“…In this test, focal uptake of thallium in the region of the CNS lesion is characteristic of a neoplastic process, whereas absence of uptake in the area of the lesion is suggestive of a nonneoplastic process, such as an abscess. In one study of 13 AIDS patients with intracranial masses, thallium-201 SPECT was able to correctly rule out lymphoma in all six patients with studies showing no focal uptake [36]. Of the seven subjects with "positive" tests, six were proven to have lymphoma while one was found to have an infectious process (toxoplasmosis and cytomegalovirus).…”

Section: Imagingmentioning

confidence: 98%

Brain abscess, subdural empyema, and intracranial epidural abscess

Calfee

Wispelwey

1999

Curr Infect Dis Rep

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Brain abscess, subdural empyema, and intracranial epidural abscess are three of the most commonly encountered focal suppurative processes of the central nervous system. A great deal has been known about the epidemiology and pathogenesis of these entities for quite some time, but until recent years the associated morbidity and mortality remained very high. New imaging techniques have allowed for more rapid detection and more precise localization of these lesions for surgical drainage. Empiric antimicrobial regimens that are effective within the abscess environment and that are directed against the most likely pathogens have also contributed to the improved outcomes seen in the current literature. This article will discuss some of the more recent advances in the diagnosis and treatment of these suppurative lesions within the central nervous system.

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Diagnosis of intracranial lymphoma in patients with AIDS: value of 201TI single-photon emission computed tomography.

Abstract: OBJECTIVE.Although

Cited by 63 publications

References 0 publications

Progressive multifocal leukoencephalopathy in rheumatic diseases: Evolving clinical and pathologic patterns of disease

Progressive multifocal leukoencephalopathy in rheumatic diseases: Evolving clinical and pathologic patterns of disease

Focal Neurological Disease in Patients with Acquired Immunodeficiency Syndrome

Brain abscess, subdural empyema, and intracranial epidural abscess

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