Diagnosis of Iron Deficiency Anemia in the Elderly by Transferrin Receptor–Ferritin Index

Rimon, Ephraim; Levy, Shmuel; Sapir, Alexander; Gelzer, Gregorius; Peled, Ronit; Ergas, David; Sthoeger, Zev

doi:10.1001/archinte.162.4.445

Cited by 122 publications

(62 citation statements)

References 33 publications

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“…The R/F ratio can also be affected by inflammation. However, at least in the elderly, the R/F ratio may be more sensitive than the classic blood tests [66] and may be more sensitive in distinguishing iron deficiency anemia from the anemia of chronic disease [67]. A major problem is the lack of standardization of the sTfR assay.…”

Section: Signs and Symptomsmentioning

confidence: 99%

Iron deficiency: A concise review

2005

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Iron deficiency is a major worldwide health problem. There is recent evidence that the anemia is only the last manifestation of the syndrome and that symptoms occur before the anemia is manifest. Advances in outlining the physiology of iron deficiency have been made, gaps remain in the current understanding. While oral iron supplement remains the mainstay, some indications for the intravenous administration have developed. This review will highlight the epidemiology, physiology, clinical presentation, and treatment options. Am.

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Section: Signs and Symptomsmentioning

confidence: 99%

Iron deficiency: A concise review

2005

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“…Besides the spleen, the liver is the chief site of iron storage, containing 98% of total iron and a large abundance of transferrin receptors (TfRs). Synthesis of the TfR, a glycoprotein that binds the diferric transferrin molecule, is highly regulated by iron (Rimon et al, 2002). Al has pro-oxidative effects in vitro and in vivo (Exley, 2004).…”

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confidence: 99%

Effects of aluminium sulphate in the mouse liver: Similarities to the aging process

Stacchiotti¹,

Llombart‐Bosch²,

Ferroni³

et al. 2008

Experimental Gerontology

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“…Iron deiciency is documented by a low serum iron level, an increased total iron-binding capacity, and a low serum ferritin level (<15 ng/mL) [17]. In cases associated with chronic inlammation, the transferrin receptor-ferritin index appears to be the most appropriate parameter to discriminate between the two disorders [17].…”

Section: Biological Abnormalities Related To Nutritional Anemiamentioning

confidence: 99%

“…In cases associated with chronic inlammation, the transferrin receptor-ferritin index appears to be the most appropriate parameter to discriminate between the two disorders [17].…”

Section: Biological Abnormalities Related To Nutritional Anemiamentioning

confidence: 99%

Nutritional Anemia in Elderly Patients of Developed Countries

Andrès¹

2018

Current Topics in Anemia

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In this chapter, we report and discuss the current literature of nutrient-deiciency anemia, also called nutritional anemia, in elderly patients in developed countries. For this purpose, a review of medical literatures was conducted searching PubMed, textbooks of hematology, internal medicine and geriatrics, and information collected from international meetings were also included. The term nutrient deiciency or nutritional anemia covers any anemia, deined by a hemoglobin level <13 g/dL (<130 g/L) in men and <12 g/dL (<120 g/L) in women, resulting from a deiciency of materials essential for erythropoiesis. Patients with nutritional anemia often have mild to moderate anemia, with hemoglobin levels between 8 and 10 g/dL (80 and 100 g/L). In practice, nutritional anemia represents one-third of all anemia in elderly patients. About two-third of nutritional anemia is associated with iron deiciency and most of those cases are the result of chronic blood loss from gastrointestinal lesions. The remaining cases of nutritional anemia are usually associated with vitamin B12 (cobalamin), most frequently related to food-cobalamin malabsorption (especially in case of atrophic gastritis), and Biermer's disease (pernicious anemia); and/or vitamin B9 (folate) deiciency, most frequently related to inadequate dietary intake or malnutrition, several drugs (as methotrexate, cotrimoxazole) and chronic alcohol intake. In clinical practice, recognition of these disorders and deiciencies is essential for optimal treatment (nutrient-deiciency replacement).

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Diagnosis of Iron Deficiency Anemia in the Elderly by Transferrin Receptor–Ferritin Index

Abstract: The diagnosis of IDA in the elderly by means of routine blood tests has a very low sensitivity. The TR-F index is much more sensitive, and when results are positive, the TR-F index can eliminate the need for bone marrow examination.

Cited by 122 publications

References 33 publications

Iron deficiency: A concise review

Iron deficiency: A concise review

Effects of aluminium sulphate in the mouse liver: Similarities to the aging process

Nutritional Anemia in Elderly Patients of Developed Countries

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