Diagnosis of Minimal Hepatic Encephalopathy of Cirrhotic Patients Using a Combination of Neuropsychiatric and Neurophysiological Tests

El-Sherif, Assem; Abdelrazik, Fathy Ghamry; A, Helal; Ali, Ahmed Essmet; Abdelsayed, Mohamed Mahmoud

doi:10.21608/ejhm.2018.15411

Cited by 2 publications

(5 citation statements)

References 9 publications

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“…These findings signify the sensitivity of using the 15 min check size in detecting abnormalities that couldn't be detected by the 1 degree check size VEP. Both the original and more recent EP investigations for cirrhotic patients were confined to latency impairment (Zhang et al, 2013;El-Sherif et al 2018;Abdelfattah et al, 2018). According to our calculated cutoff, 6 patients were found to be abnormal in PVEP 1degree check size with only latency abnormality, and 13 patients were found to be abnormal in PVEP 15 min check size ( with delayed latency abnormality in all cases, and amplitude abnormality in only 3 cases).…”

Section: Discussionmentioning

confidence: 83%

“…Many published researches had investigated the role of VEP, SSEP, BAEP and EEG in diagnosis of HE. Zhang et al, 2013;El-Sherif et al 2018. For the best of our knowledge , no previous studies had investigated 2 different check sizes in pVEP ( large and small check sizes) in cirrhotic patients.…”

Section: Discussionmentioning

confidence: 99%

“…MHE is one of the most debilitating complications, it affects the quality of life of the patient in addition to increase the socioeconomic burden on the family members and caregivers Ridolaa et al, 2018. Neurophysiological investigations helps in assessment of the neuronal and electrogenesis via a functional point of view. Also, have been used for quantitative assessment and follow-up of several diseases El-Sherif et al, 2018. Visual electrophysiology is a simple, non-invasive, objective and reliable method. However Visual evoked potentials (VEPs) were first described to asses abnormalities only in the visual system; they are now widely used in evaluation of different neurological and metabolic disorders Zhang et al, 2013.…”

Section: Introductionmentioning

confidence: 99%

“…Jancic et al, 2016. VEP recordings have been used in evaluation of hepatic cirrhosis and minimal hepatic encephalopathy. It showed promising results in detection of minimal hepatic encephalopathy El-Sherif et al, 2018. Several researches have been done to investigate the role of VEPs in the detection of cortical affection among cirrhotic patients (Guerit et al, 2009;Amodio & Montagnese, 2015). El-Sherif et al 2018, studied VEP and psychometric test in thirty patients with liver cirrhosis and no clinical evidence of HE .…”

Section: Introductionmentioning

confidence: 99%

“…MHE is diagnosed by having one abnormal electrophysiological study or psychometric testing. El-Sherif et al 2018. For the best of our knowledge no previous work studied the effect of 2 different checksizes .…”

Section: Introductionmentioning

confidence: 99%

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Different check sizes pattern-reversal visual evoked potentials study in patients with compensated hepatic cirrhosis

Elfatah

Soliman

Hammad

et al. 2022

ijhs

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Background: Cirrhosis is a dynamic process starts after sustained inflammation, followed by necrosis of liver cells and fibrosis that occur as a normal wound healing response then nodular formation that eventually lead to hepatic dysfunction. Aim and objectives: Study the effect of hepatic cirrhosis on cerebral cortex and subcortical pathways using VEP, and Comparison between different VEP check sizes in detection of early encephalopathy among cirrhotics. Subjects and methods: This was a case/control study carried out on 45 cirrhotic patients, and 45 matched normal controls. All subjects underwent full opthalmological assesment prio to the conduction of the PVEP, after the approval of the ethical committee. Results: the studied cases had significantly more delayed latency and lower amplitude than the studied controls on both sides at both 1 degree and 15 minutes check sizes (P-value<0.05), however 13 patiebts were detected by the 15 min check size to be abnormal on he contrary of the 1 degree chech size that detected changes only in 6 patients. Conclusion: Vep 15 min is more sensitive in detecting early changes in cirrhotic patients. denoting that most of the hepatic encephalopathy changes are affecting the central visual field.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Different check sizes pattern-reversal visual evoked potentials study in patients with compensated hepatic cirrhosis

Elfatah

Soliman

Hammad

et al. 2022

ijhs

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Psychometric Hepatic Encephalopathy Tests and Electroencephalogram Results Among Cirrhotic Patients

Mohamed,

Elkholy,

Mangoud

et al. 2024

Medicina

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Background and Objectives: Patients with cirrhosis who seem normal during physical examinations may still have abnormalities in their electroencephalogram (EEG) or show pathological results in neuropsychological tests. This study aimed to investigate the progression of minimal hepatic encephalopathy, its effects on quality of life, its prognostic value, and its significance for daily functioning. Materials and Methods: This study involved 50 patients with confirmed cirrhosis (28 Child A, 12 Child B, 10 Child C) who were assessed for psychological symptoms and underwent several tests: the Minimal Mental State Examination (MMSE), the Letter Cancellation Test, the Digit Symbol Coding Test, and EEG. Results: showed that 40% of patients exhibited neuropsychiatric symptoms, with somatization being the most common at 96%. The MMSE revealed cognitive impairment in 48% of patients. In the Letter Cancellation Test (LCT) (total error), 80% of patients had organic disorders, and 24% showed affections with (LCT) (completion time). The Digit Symbol Coding Test results showed affection in 28% of patients. Significant EEG changes were observed in patients with Child C cirrhosis. Patients with portal hypertension (including varices and variceal bleeding), liver cell failure symptoms (such as ascites, lower limb edema, and bleeding tendency), as well as those who smoke, or obese, or have hyperlipidemia, all displayed notable EEG and psychological test abnormalities, making them more likely to develop hepatic encephalopathy. Conclusions: psychological testing and EEG changes are effective in detecting minimal hepatic encephalopathy, with a higher incidence in Child C patients compared to those in Child A and B.

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Diagnosis of Minimal Hepatic Encephalopathy of Cirrhotic Patients Using a Combination of Neuropsychiatric and Neurophysiological Tests

Cited by 2 publications

References 9 publications

Different check sizes pattern-reversal visual evoked potentials study in patients with compensated hepatic cirrhosis

Different check sizes pattern-reversal visual evoked potentials study in patients with compensated hepatic cirrhosis

Psychometric Hepatic Encephalopathy Tests and Electroencephalogram Results Among Cirrhotic Patients

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