Diagnosis of Neural Activity among Abnormal Brain Regions in Patients with Major Depressive Disorder by Magnetic Resonance Imaging Features

Abstract

In order to explore the diagnostic value of magnetic resonance imaging (MRI) for neural activity among abnormal brain regions in patients with major depressive disorder (MDD), thirty patients with MDD (observation group) were selected for comparison with 30 healthy people without MDD (control group). The included subjects were examined by MRI to compare the MRI features and were analyzed for regional homogeneity (ReHo) and amplitude low-frequency fluctuations (ALFF). The results showed that compared with the control group, the brain regions with increased ReHo and ALFF in the observation group were medial frontal gyrus (right), middle temporal lobe (left), inferior parietal lobe (left), and posterior cerebellar lobe (right); the brain region with increased ReHo and ALFF in the observation group was the middle temporal gyrus (right). Compared with the control group, there were significant differences in ReHo and ALFF in the observation group. It was found that the brain function of patients with MDD was abnormal compared with that of the normal subjects, and the brain network activity was also abnormal. MRI features can be used to explore abnormal brain regions in patients with MDD and have positive guiding value.

Multimodal abnormalities of brain structures in adolescents and young adults with major depressive disorder: An activation likelihood estimation meta-analysis

“…The high prevalence and distinct nature of adolescent and young adult MDD necessitate a nuanced understanding of its neural underpinnings. sMRI studies, including those utilizing DTI and VBM, have provided valuable insights into brain structural anomalies associated with MDD[ 36 ]. However, the variability in research outcomes highlights the complexity of the disease and the impact of individual and methodological differences[ 37 ].…”