Diagnosis of Papillary Thyroid Carcinoma in Fine Needle Aspiration Smears

Das, Dilip K.

doi:10.1159/000325375

Cited by 14 publications

(21 citation statements)

References 15 publications

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“…[23] Diagnosis of FVPTC could be missed in the absence of characteristic nuclear features of PTC even though presence of high cellularity, microfollicular pattern and less colloid favors diagnosis of follicular neoplasm. [202324] In our study, we diagnosed two cases of FVPTC but missed diagnosis in three cases because of the absence of nuclear features.…”

Section: Discussionmentioning

confidence: 70%

“…[26] Therefore, nuclear features and high cellularity are useful in diagnosing papillary carcinoma. [24] Cystic change could be seen in developmental/congenital, hyperplastic and neoplastic entities like cystic PTC and rarely in follicular neoplasm. Only 10–15% of the cysts are neoplastic; however, papillary thyroid carcinomas are important because of false negative diagnosis in FNAC.…”

Section: Discussionmentioning

confidence: 99%

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A cell pattern approach to interpretation of fine needle aspiration cytology of thyroid lesions: A cyto-histomorphological study

Bommanahalli

Bhat

Rupanarayan

2010

J Cytol

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Aim:Our study aimed at a cell pattern approach to interpret thyroid cytology and to demonstrate diagnostic accuracy of fine needle aspiration cytology (FNAC) with an emphasis on diagnostic pitfalls.Materials and Methods:A total number of 218 goitre cases, from the year 2000 to 2004, were reviewed retrospectively from the cytology files, without considering the previous cytological diagnosis. Four cases with inadequate aspirate were excluded. The predominant cell pattern, such as macro/normofollicular, microfollicular, papillary, syncytial, dispersed and cystic pattern, was noted in each case. The final diagnosis was arrived by observing the cellular details and background elements. Cytological diagnosis was correlated with histopathology in 75 cases. The sensitivity and specificity were computed.Results:Normo/macrofollicular pattern was seen in 71.96% of nodular goitre and 6.9% of follicular neoplasms. Around 86.2% of follicular neoplasms and 17.6% of papillary carcinoma had microfollicular pattern. The papillary pattern was seen in 47% of papillary carcinoma. Syncytial pattern was noticed in 72.3% of chronic lymphocytic thyroiditis and 29.4% of papillary carcinoma. Cytological diagnosis was concordant with histopathological diagnosis in 65 cases. Overall sensitivity and specificity of FNAC in diagnosing neoplastic lesions of thyroid were 83.33 and 95.55%, respectively.Conclusion:FNAC is more sensitive and specific in triaging neoplastic from non-neoplastic thyroid lesions. Identification of the predominant cell pattern would be complementary to analysis of cell morphology and background details in cytological diagnosis of thyroid lesions. This approach helps to diagnose follicular neoplasm and follicular variant of papillary thyroid carcinoma.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

A cell pattern approach to interpretation of fine needle aspiration cytology of thyroid lesions: A cyto-histomorphological study

Bommanahalli

Bhat

Rupanarayan

2010

J Cytol

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“…Psammoma bodies are seen rarely. [14] Das et al ,[15] suggested that “cystic papillary carcinoma” is a common cause for false negative reports in cytology. Problems in diagnosing papillary carcinoma include cystic change, marked lymphocytic infiltration, mixed patterns of growth, papillary adenoma, hyalinizing trabecular adenoma and calcified debris.…”

Section: Discussionmentioning

confidence: 99%

Insight to neoplastic thyroid lesions by fine needle aspiration cytology

Rangaswamy

Narendra

Patel

et al. 2013

J Cytol

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Background:Fine needle aspiration cytology (FNAC) is a valuable adjunct to pre-operative screening in the diagnosis of thyroid nodules, and in most cases, it can distinguish between benign and malignant lesions.Aim:To study the cytology of neoplastic thyroid lesions to minimize surgical intervention and for confirmation of the diagnosis by histopathological study.Materials and Methods:100 cases of thyroid FNAC smears were analyzed and cyto-histopathological correlation was done in 47 cases. Galen and Gambino's method was used to calculate the sensitivity and positive predictive value.Results:Of the 100 cases, 90 were diagnosed as neoplastic lesions by FNAC and ten cases as non-neoplastic lesions, which turned out to be neoplasms on histopathological study. Among 100 cases, 47 were biopsied and subjected to histopathological study. The sensitivity of FNAC was 75.60%, and positive predictive value was 83.78% for malignant lesions.Conclusions:FNAC is a rapid, efficient, cost-effective, relatively painless procedure with a high diagnostic accuracy. It has high rate of sensitivity and positive predictive value in diagnosing thyroid neoplastic lesions. Hence, it is a valuable tool in the diagnosis and management of patients.

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“…Liquid-based cytology offers the possibility of creating archival material and applying new techniques, such as immunocytochemistry in the same sample, and this is significant for further and future revaluation. The gold standard of immunocytochemistry, in order to lead to an accurate diagnosis, is the use of a panel with at least two or three markers in combination with cytomorphology [17, 24]. Attention should be made to the extent, intensity, and pattern of staining.…”

Section: Discussionmentioning

confidence: 99%

“…Attention should be made to the extent, intensity, and pattern of staining. Liquid-based cytology has been validated extensively for the preoperative diagnosis of thyroid nodules [23, 24]. This method is fully reproducible, performed by minimum training of personnel, is safe, time effective, and offers the possibility of an accurate application of immmunocytochemistry for the study of neoplastic thyroid lesions.…”

Section: Discussionmentioning

confidence: 99%

The Immunocytochemistry Is a Valuable Tool in the Diagnosis of Papillary Thyroid Cancer in FNA's Using Liquid-Based Cytology

Pazaitou‐Panayiotou

Mygdakos

Boglou

et al. 2010

Journal of Oncology

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Introduction. Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid. An accurate cytological diagnosis is based on distinctive cytological features in combination with immunocytochemistry. Methods. A number of 83 fine needle aspirations, positive for papillary thyroid cancer (44 from thyroid nodules and 39 from cervical lymph nodes), were studied using Thin Layer Cytology. A panel of the immunomarkers Cytokeratin-19, Galectin-3, HBME1, CD-44, CD-56, and E-Cadherin was performed. Results. Positive expression of CK-19 was observed in 77 cases (92.7%), of Galectin-3 in 74 cases (89.1%), of HBME1 in 65 (78.3%), and of CD-44 in 72 cases (86.7%). Loss of expression of CD-56 was observed in 80 cases (96.4%) and of E-cadherin in 78 (93.9%). Conclusions. Our data suggest that Thin Layer Cytology increases the diagnostic accuracy in papillary carcinoma and seems to be a promising technique for further investigation of thyroid lesions permitting the possibility to use archive material. Positive immunoexpression of CK-19, Galectin-3, HBME-1, and CD-44 improves the diagnostic accuracy of papillary thyroid cancer. Furthermore, loss of E-cadherin and of CD-56 expression is a feature of malignancy.

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Diagnosis of Papillary Thyroid Carcinoma in Fine Needle Aspiration Smears

Cited by 14 publications

References 15 publications

A cell pattern approach to interpretation of fine needle aspiration cytology of thyroid lesions: A cyto-histomorphological study

A cell pattern approach to interpretation of fine needle aspiration cytology of thyroid lesions: A cyto-histomorphological study

Insight to neoplastic thyroid lesions by fine needle aspiration cytology

The Immunocytochemistry Is a Valuable Tool in the Diagnosis of Papillary Thyroid Cancer in FNA's Using Liquid-Based Cytology

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