Diagnosis of PD

Hughes, Aaron; Ben-Schlomo, Y.; Daniel, Sara; Lees, Andrew J.

doi:10.1212/wnl.43.8.1630

Cited by 5 publications

(2 citation statements)

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“…The presence of a history or signs or symptoms of stroke was noted, as well as the presence of diabetes and hypertension. Idiopathic PD was defined by clinical and research criteria (Hughes et al, 1992a(Hughes et al, , 1992bWard & Gibb, 1990). Patients with secondary parkinsonism resulting from phenothiazines, alphamethyldopa, reserpine, or metaclopramide hydrochloride, and patients with clinical presentations suggesting progressive supranuclear palsy, essential tremor, Shy-Drager syndrome, presumed striatonigral degeneration, and olivopontocerebellar atrophy were excluded.…”

Section: Diagnostic Evaluationmentioning

confidence: 99%

Prospective comparative study of the evolution of probable Alzheimer's disease and Parkinson's disease dementia

Stern

Tang

Jacobs

et al. 1998

J Int Neuropsychol Soc

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No previous comparison of test performance in probable Alzheimer's disease (pAD) and Parkinson's disease (PD) dementia has provided information about potential differences in the dementing process. This study compared the evolution of cognitive changes associated with these dementias. Generalized estimating equations (GEE) applied to regression analyses with repeated measures were used to evaluate cognitive changes over 1 to 3 years prior to the point when dementia was diagnosed in 40 matched pairs of patients with incident pAD and PD dementia. Both groups' performance declined on the Short Blessed, Selective Reminding Test (SRT; total recall, long-term retrieval, and delayed recall), Boston Naming Test, Category Fluency, and Similarities. The decline on naming and SRT delayed recall was more rapid in the PD dementia group, suggesting that these performance deficits emerge earlier in the development of pAD. The PD dementia group performed worse on Category Fluency throughout the follow-up period, suggesting either that dementia is overlaid on this preexisting performance deficit or that this type of executive deficit is an early manifestation of dementia in PD. The pAD group performed more poorly throughout the follow-up period on SRT delayed recognition, consistent with a pAD-specific encoding deficit. We conclude that while pAD and PD dementia are similar in many respects, differences in their evolution support previous observation of unique features in the 2 dementias and suggest different underlying pathologies. (JINS, 1998, 4, 279–284.)

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Section: Diagnostic Evaluationmentioning

confidence: 99%

Prospective comparative study of the evolution of probable Alzheimer's disease and Parkinson's disease dementia

Stern

Tang

Jacobs

et al. 1998

J Int Neuropsychol Soc

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“…The strength is that a large number of brains can be collected. The weaknesses are that there are many (more than 70) physicians including neurologists and geriatricians who look after these patients and collect the clinical data 32 . The autopsies are performed locally at multiple sites, thus there is a lack of uniformity of the clinical data and the brain harvesting. National Essential Tremor repository in the United States 33 …”

Section: Our Resource Is Not a Brain Bankmentioning

confidence: 99%

Saskatchewan Movement Disorders Program

Rajput

2015

Can. J. Neurol. Sci.

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We review the Saskatchewan Movement Disorders Program, which started in 1968 and has had the dual goals of patient care and research. The clinics are structured to collect research-worthy data including videos, longitudinal follow-up, and autopsy studies of patients seen in the clinics. At every clinic visit, the patient is evaluated by one or both authors. A total of 25% to 30% of the deceased come to autopsy. Frozen half-brain and formalin-fixed remnants from autopsy are preserved in our laboratories. Patients not seen in our clinic are not included in research, which makes it different from brain banks. So far, 515 cases have come to autopsy. So far, there have been 17 collaborating scientific teams from Canada, the United States, Europe, and Japan. The collaborators are not charged for access to our resources. This program offers a unique opportunity to study multiple aspects of movement disorder patients seen in clinical practice.

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Diagnostic Criteria for Parkinson Disease

1999

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The clinical diagnosis of Parkinson disease (PD) is based on the identification of some combination of the cardinal motor signs of bradykinesia, rigidity, tremor, and postural instability, but few attempts have been made to develop explicit diagnostic criteria. We propose a clinical diagnostic classification based on a comprehensive review of the literature regarding the sensitivity and specificity of the characteristic clinical features of PD. Three levels of diagnostic confidence are differentiated: Definite, Probable, and Possible. The diagnoses of Possible and Probable PD are based on clinical criteria alone. Neuropathologic confirmation is required for the diagnosis of Definite PD in patients with the clinical diagnosis of Possible or Probable PD. Criteria for histopathologic confirmation of PD are also presented.

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Diagnosis of PD

Cited by 5 publications

References 0 publications

Prospective comparative study of the evolution of probable Alzheimer's disease and Parkinson's disease dementia

Prospective comparative study of the evolution of probable Alzheimer's disease and Parkinson's disease dementia

Saskatchewan Movement Disorders Program

Diagnostic Criteria for Parkinson Disease

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