Diagnosis of pleural infection: state-of-the-art

Tobin, Claire; Porcel, José M.; Wrightson, John; Waterer, Grant; Light, Richard W.; Lee, Y. C. Gary

doi:10.1007/s13665-012-0011-3

Cited by 8 publications

(3 citation statements)

References 94 publications

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“…Pleural space infections have been described since the time of Hippocrates [ 1 – 4 ] and unfortunately remain an ongoing problem in modern day healthcare [ 5 – 7 ]. While morbidity and mortality have improved [ 2 ], recent data suggests growing concerns related to pleural infection incidence and management [ 8 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of Intrapleural Tissue Plasminogen Activator and DNase during Extended Use in Complicated Pleural Space Infections

McClune

Wilshire

Gorden

et al. 2016

Canadian Respiratory Journal

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The use of intrapleural therapy with tissue plasminogen activator and DNase improves outcomes in patients with complicated pleural space infections. However, little data exists for the use of combination intrapleural therapy after the initial dosing period of six doses. We sought to describe the safety profile and outcomes of intrapleural therapy beyond this standard dosing. A retrospective review of patients receiving intrapleural therapy with tissue plasminogen activator and DNase was performed at two institutions. We identified 101 patients from January 2013 to August 2015 receiving intrapleural therapy for complicated pleural space infection. The extended use of intrapleural tissue plasminogen activator and DNase therapy beyond six doses was utilized in 20% (20/101) of patients. The mean number of doses in those undergoing extended dosing was 9.8 (range of 7–16). Within the population studied there appears to be no statistically significant increased risk of complications, need for surgical referral, or outcome differences when comparing those receiving standard or extended dosing intrapleural therapy. Future prospective study of intrapleural therapy as an alternative option for patients who fail initial pleural drainage and are unable to tolerate/accept a surgical intervention appears a potential area of study.

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Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of Intrapleural Tissue Plasminogen Activator and DNase during Extended Use in Complicated Pleural Space Infections

McClune

Wilshire

Gorden

et al. 2016

Canadian Respiratory Journal

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“…Pleural effusion produces a low signal on T 1 -Weighted and high signal on T 2 -Weighted images. [3] On MR imaging, stones present as non-specific signal voids, overlooked, or confused with other structures or artifacts. Because of this limitation, guidelines have excluded MRI as a kidney stone imaging modality.…”

Section: Methodsmentioning

confidence: 99%

Incidental Extraspinal Findings in the Thoracic Spine during Magnetic Resonance Imaging of Intervertebral Discs

Zidan

Hassan

Elnour

et al. 2019

JCIS

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Objective: The purpose of this research was to determine the frequency of incidental extraspinal findings in the thoracic spine on magnetic resonance imaging (MRI). Materials and Methods: A total of 120 thoracic spine MRI patients were prospectively examined in the period extending from August 2018 to April 2019. Both 1.5 and 0.35 Tesla MRI systems (Toshiba and Siemens Medical system) were applied to investigate patients with suspected intervertebral disc abnormalities at three MRI diagnostic centers in Khartoum, Sudan. Results: Out of the 120 patients, incidental extraspinal findings were found in 16 patients (13.3%). Various incidental findings (IFs) were seen, including renal cysts, liver mass, thyroid goiter, and pleural effusion. Out of these IFs, 37.5% were considered clinically significant. Conclusions: Various IFs were identified during a routine thoracic spine MRI, and approximately one-third of them were clinically significant. Therefore, it is essential for the reporting radiologists to pay attention to extraspinal findings while reporting thoracic spine MRI to avoid missing clinically significant findings.

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“…On MRI imaging, parapneumonic effusions have a low signal on T1-weighted and high signal on T2-weighted. It is superior to CT in detecting pleural fluid septation and extra-pleural fat changes [ 40 ]. This imaging modality may be used in MPE to evaluate soft tissue invasion such as chest wall, diaphragmatic and spinal invasion [ 23 ].…”

Section: Pleural Infectionmentioning

confidence: 99%

Imaging of pleural disease

Hassan,

Touman,

Grabczak

et al. 2024

Breathe

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The pleural space is a “potential” anatomical space which is formed of two layers: visceral and parietal. It normally contains a trace of fluid (∼10 mL in each hemithorax). Diseases of the pleura can manifest with thickening of the pleural membranes or by abnormal accumulation of air or liquid. Chest radiographs are often the first imaging tests to point to a pleural pathology. With the exception of pneumothorax, and due to the inherent limitations of chest radiographs, ultrasound and/or computed tomography are usually required to further characterise the pleural pathology and guide management. This review summarises the utility of different imaging tools in the management of pleural disease and discusses new and evolving tools in imaging of the pleura.

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Diagnosis of pleural infection: state-of-the-art

Cited by 8 publications

References 94 publications

Safety and Efficacy of Intrapleural Tissue Plasminogen Activator and DNase during Extended Use in Complicated Pleural Space Infections

Safety and Efficacy of Intrapleural Tissue Plasminogen Activator and DNase during Extended Use in Complicated Pleural Space Infections

Incidental Extraspinal Findings in the Thoracic Spine during Magnetic Resonance Imaging of Intervertebral Discs

Imaging of pleural disease

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