Diagnosis of postoperative pancreatic fistula

Abstract

Lipase concentration in the abdominal drain correlated with PF. A threshold of 1000 units/l yielded a high sensitivity and specificity for the diagnosis of clinical PF.

Systematic Review and Meta-Analysis of Somatostatin Analogues in the Prevention of Postoperative Complication after Pancreaticoduodenectomy

“…An important source of clinical heterogeneity may come from the variability in definition of PF. A more strict definition may result in a higher rate of PF, while a more compromised definition may lead to a lower rate of PF [49]. The same is true for clinically significant PF.…”

Comparison of lipase and amylase for diagnosing post‐operative pancreatic fistulae

“…Despite the evolution of surgical techniques and peri‐operative care, pancreatic surgery has a reported mortality rate of up to 5% and a morbidity rate of 30–50% . Post‐operative pancreatic fistula (POPF) is a common complication of pancreatic surgery.…”

Can early serum lipase measurement be routinely implemented to rule out clinically significant pancreatic fistula after pancreaticoduodenectomy?

“…Facy [18] examined the association between lipase measured in the abdominal drainage fluid and POPF, without looking at serum lipase concentrations. For clinical fistulas the sensitivity was 93% and specificity 77% when the threshold for lipase was 1000 U/L.…”