Diagnosis of Proximal Gastro-Oesophageal Reflux in Patients With Rhonchopathy and Sleep Apnoea

Moré, Eduard Esteller; Zumel, Paula Huerta; Aguilar, Inés Modolell; Isern, Francesc Segarra; Soler, Eusebi Matiñó; Gonzalez, A.; Alcover, Joan Manel Ademà

doi:10.1016/s2173-5735(07)70390-3

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…The interaction of genes that affect obesity, craniofacial morphology, the occurrence of respiratory disorders, daytime sleepiness, with "favorable" external factors, can lead to the formation of a predisposition to OSAHS, and therefore OSAHS should be considered as a multifactorial (polygenic) hereditary disease. In general, about 35-40% of all OSAHS cases can be explained by genetic factors [20]. Thus, a number of researchers believe that in the presence of relatives of the first degree of kinship in the family, suffering from OSAHS, the risk of developing this disease in a proband increases more than 2 times compared with the average population [21].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Associative Relationship of Allelic and Genotypical Variants of Polymorphism Rs 2010963 of the VEGFA Gene with Formation and Development of Ronchopathy

Saidakramovich¹,

Salomovich*²

2021

IJADST

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It is interesting to note that the adverse effect of this genotype was observed exclusively in patients with ronchopathy, while in patients with ronchopathy, the frequency of this genotype did not differ in comparison with the control group, i.e. there is a significant tendency to an increase in the genotype with an increase in the severity of the pathology. Material and methods. To solve the set tasks, 208 patients with various diseases of the upper respiratory tract, with nasal breathing disorders, causing ronchopathy, who were hospitalized in the ENT department of the multidisciplinary clinic of the Tashkent Medical Academy for 2015 to 2021, were examined. The control group consisted of 50 apparently healthy people who agreed to participate in the study (students, masters, clinical residents). Among the sick men there were 144 (73%), women - 64 (27%). The age of the patients ranged from 18 to 70 years, averaging 44.5 ± 6.8 years. Molecular genetic studies were carried out in the Department of Molecular Medicine and Cell Technologies of the RSNPMC Hematology. This part of the work consisted of several stages: 1. Blood sampling. 2. Isolation of DNA from peripheral blood lymphocytes. 3. Carrying out PCR. 4. Conducting electrophoresis and visualizing the results (if necessary). The analysis of the TGFb1 gene polymorphism associations was carried out using a case-control model (casecontrol, comparison of two samples). The sample "case" was formed from 104 patients with ronchopathy. Conclusion. Since this work is one of the few works on the study of the relationship between rs 2010963 of the VEGFA gene and the risk of developing ronchopathy, our data may become the subject of further discussions.

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Section: Introductionmentioning

confidence: 99%

Analysis of Associative Relationship of Allelic and Genotypical Variants of Polymorphism Rs 2010963 of the VEGFA Gene with Formation and Development of Ronchopathy

Saidakramovich¹,

Salomovich*²

2021

IJADST

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Reflujo faringolaríngeo, génesis o comorbilidad de roncopatía y síndrome de apnea hipopnea obstructiva de sueño

Cristiano

Herrera

Ugalde

2018

Acta otorrinolaringol cir cabeza cuello

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Siendo el reflujo faringolaríngeo, roncopatía y síndrome de apnea hipopnea obstructiva de sueño (SHAOS) hoy día patologías frecuentes en la población general y objeto de remisión a la consulta otorrinolaringológica, ya sea como eventos aislados o bajo estado comórbido, se hace imperioso conocer su mecanismo de presentación, relación y ruta diagnóstico terapéutica, así pues se realiza una revisión de la literatura que aunado a la experiencia clínica ofrecen una perspectiva de las condiciones objeto de análisis bajo presentación concomitante, siendo necesario a futuro efectuar estudios prospectivos que determinen la eficacia cuantitativa de las medidas sugeridas.

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Analysis of Associative Relationship of Allelic and Genotypical Variants of Polymorphism Rs 2010963 of the VEGFA Gene with Formation and Development of Ronchopathy

Khasanov

S.S.Sharipov²

2021

IJADST

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It is interesting to note that the adverse effect of this genotype was observed exclusively in patients with ronchopathy, while in patients with ronchopathy, the frequency of this genotype did not differ in comparison with the control group, i.e. there is a significant tendency to an increase in the genotype with an increase in the severity of the pathology. Material and methods. To solve the set tasks, 208 patients with various diseases of the upper respiratory tract, with nasal breathing disorders, causing ronchopathy, who were hospitalized in the ENT department of the multidisciplinary clinic of the Tashkent Medical Academy for 2015 to 2021, were examined. The control group consisted of 50 apparently healthy people who agreed to participate in the study (students, masters, clinical residents). Among the sick men there were 144 (73%), women – 64 (27%). The age of the patients ranged from 18 to 70 years, averaging 44.5 ± 6.8 years. Molecular genetic studies were carried out in the Department of Molecular Medicine and Cell Technologies of the RSNPMC Hematology. This part of the work consisted of several stages: 1. Blood sampling. 2. Isolation of DNA from peripheral blood lymphocytes. 3. Carrying out PCR. 4. Conducting electrophoresis and visualizing the results (if necessary). The analysis of the TGFb1 gene polymorphism associations was carried out using a case-control model (case-control, comparison of two samples). The sample “case” was formed from 104 patients with ronchopathy. Conclusion. Since this work is one of the few works on the study of the relationship between rs 2010963 of the VEGFA gene and the risk of developing ronchopathy, our data may become the subject of further discussions.

show abstract

Diagnosis of Proximal Gastro-Oesophageal Reflux in Patients With Rhonchopathy and Sleep Apnoea

Cited by 3 publications

References 37 publications

Analysis of Associative Relationship of Allelic and Genotypical Variants of Polymorphism Rs 2010963 of the VEGFA Gene with Formation and Development of Ronchopathy

Analysis of Associative Relationship of Allelic and Genotypical Variants of Polymorphism Rs 2010963 of the VEGFA Gene with Formation and Development of Ronchopathy

Reflujo faringolaríngeo, génesis o comorbilidad de roncopatía y síndrome de apnea hipopnea obstructiva de sueño

Analysis of Associative Relationship of Allelic and Genotypical Variants of Polymorphism Rs 2010963 of the VEGFA Gene with Formation and Development of Ronchopathy

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