Diagnosis of Pulmonary Embolism Based upon Alveolar Dead Space Analysis

Eriksson, Leif; Wollmer, Per; Olsson, Carl; Albrechtsson, U.; Lárusdóttir, H.; Nilsson, Roma; Sjögren, Anders; Jonson, B.

doi:10.1378/chest.96.2.357

Cited by 86 publications

(81 citation statements)

References 8 publications

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“…method of least squares. This extrapolation essentially corresponds to the extrapolation of phase III performed by Eriksson et al [3]. Eriksson et al found that if phase III, as described by the equation, was extrapolated it reached P a CO 2 at a V E corresponding to approximately 15%TLCp in normal subjects and in patients with airways disease and interstitial lung disease.…”

Section: Analysis Of the Sbt-co 2 Curvesupporting

confidence: 67%

“…We used the equation previously used by Eriksson et al [3] to describe the alveolar plateau ( Fig. 1):…”

Section: Analysis Of the Sbt-co 2 Curvementioning

confidence: 99%

“…For analysis of the present data, we used measurement of the late dead space fraction, f D late, defined by Eriksson et al [3] as:…”

Section: Analysis Of the Sbt-co 2 Curvementioning

confidence: 99%

“…Some years ago we described a method for measurement of alveolar dead space (late dead space fraction, f D late) and compared it with pulmonary angiography [3]. This study, which involved a relatively small number of patients, suggested that high sensitivity to PE can be achieved with well-preserved specificity.…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis of pulmonary embolism by measurement of alveolar dead space

Olsson

Jonson²,

Wollmer

1998

Journal of Internal Medicine

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Section: Analysis Of the Sbt-co 2 Curvesupporting

confidence: 67%

“…We used the equation previously used by Eriksson et al [3] to describe the alveolar plateau ( Fig. 1):…”

Section: Analysis Of the Sbt-co 2 Curvementioning

confidence: 99%

“…For analysis of the present data, we used measurement of the late dead space fraction, f D late, defined by Eriksson et al [3] as:…”

Section: Analysis Of the Sbt-co 2 Curvementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diagnosis of pulmonary embolism by measurement of alveolar dead space

Olsson

Jonson²,

Wollmer

1998

Journal of Internal Medicine

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“…Nevertheless, actual results also indicate extubation failure rates of 10 to 28%. 9,10 The ratio between dead space and tidal volume (VD/ VT) has already been used for the identification of pulmonary thromboembolism, 11,12 in the management of chronic obstructive pulmonary disease (COPD), 13 for prognostic evaluation of acute respiratory distress syndrome, 14 to determine the presence of pulmonary dysfunction in adults with sepsis 15 and as a factor discriminating weaning off mechanical ventilation. 16 In children, although experience is less extensive, the VD/VT ratio has already been studied as a determinant of the severity of diaphragmatic hernia in newborn infants, 17 as a parameter indicating degree of lung injury in children on mechanical ventilation 18 and as a marker of lung damage in acute respiratory distress syndrome.…”

Section: Introductionmentioning

confidence: 99%

Avaliação da relação entre espaço morto e volume corrente como índice preditivo de falha de extubação

Bousso¹,

Ejzenberg²,

Ventura³

et al. 2006

J. Pediatr. (Rio J.)

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Objective: The objective of this study was to evaluate the ratio of dead space to tidal volume (VD/VT) as a predictor of extubation failure of children from mechanical ventilation.Methods: From September 2001 to January 2003 we studied a cohort consisting of all children (1 day-15 years) submitted to mechanical ventilation at a pediatric intensive care unit who were extubated and for whom preextubation ventilometry data were available, including the VD/VT ratio. Extubation success was defined as no need for any type of ventilatory support, invasive or otherwise, within 48 hours. Patients who tolerated extubation, with or without noninvasive support, were defined as success-R and compared with those who were reintubated. Statistic analysis was based on a VD/VT cutoff point of 0.65.Results: During the study period 250 children received mechanical ventilation at the pediatric intensive care unit. Eighty-six of these children comprised the study sample. Twenty-one children (24.4%) met the criteria for extubation failure, with 11 (12.8%) of these requiring non-invasive support and 10 (11.6%) reintubation. Their mean age was 16.8 (±30.1) months (median = 5.5 months). The mean VD/VT ratio for all cases was 0.62 (±0.18). Mean VD/VT ratios for patients with successful and failed extubations were 0.62 (±0.17) and 0.65 (±0.21) (p = 0.472), respectively. Logistic regression failed to reveal any statistically significant correlation between VD/ VT ratio and success or failure of extubation (p = 0.8458), even for patients who were reintubated (p = 0.5576). Conclusions:In a pediatric population receiving mechanical ventilation due to a variety of etiologies, the VD/ VT ratio was unable to predict the populations at risk of extubation failure or of reintubation.J Pediatr (Rio J). 2006;82(5):347-53: Respiratory failure, lung disease, respiratory dead space, pulmonary volume measurement, artificial respiration, child.

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