Diagnosis of Recurrent Uterine Cervical Cancer: Computed Tomography versus Positron Emission Tomography

Park, Dong Hee; Kim, Kie Hwan; Park, Soo‐Jin; Lee, Byung Hee; Choi, Chang Woon; Chin, Soo Yil

doi:10.3348/kjr.2000.1.1.51

Cited by 41 publications

(36 citation statements)

References 23 publications

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“…In Park's study [13] , they found PET was much better than CT by reporting that the sensitivity and specifi city of CT scans was 77% and 83% respectively, and the sensitivity and specificity of PET scans was 100% and 94% respectively. Rose et al [9] indicated that PET was better than CT for lymph node detection.…”

Section: Discussionmentioning

confidence: 94%

Detection of recurrent cervical cancer by whole-body FDG PET scans

Yang

Wang

Zhu

et al. 2008

Chin. J. Clin. Oncol.

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OBJECTIVE To evaluate the role of whole-body { 18 F}fluro-2-dexoxyglucose (FDG) positron emission tomography (PET) scans in the detection of recurrent cervical cancer. METHODS Between June, 2000 and January, 2006, 25 patients had undergone a PET scan at the Peking Union Medical College Hospital to evaluate possible recurrent cervical cancer. All the PET fi ndings were reviewed and compared to available clinical data to classify each PET scan result as a true positive, true negative, false positive, or false negative. RESULTS A total of 38 PET scans were conducted on the 25 patients whose median age was 46 years. The Stage distributions were IA (n = 1), IB (n = 11), IIA (n = 5), IIB (n = 4), IIIB (n = 2), IVB (n = 1), and unknown Stage (n = 1). There were 22 cases of squamous cell carcinoma and 3 cases of adenocarcinoma resulting in 9 true positive PET scans, 27 true negatives, 2 false positives and no false negatives. The sensitivity of the FDG PET scans for detecting recurrent cervical cancer was 100%, specificity 93.1%, positive predictive value 81.8%, and negative predictive value 100%. CONCLUSION The whole body FDG PET scans are a sensitive and specific imaging modality for the detection of recurrent cervical cancer. However the cost of PET scans is too high at this time. A large prospective study will determine whether this modality should be used routinely and take the place of other imaging methods in the early detection of recurrent cervical carcinoma KEY WORDS: tomography, emission-computed, positron, 18 F-fl uorodeoxyglucose, recurrent cervical cancer.

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Section: Discussionmentioning

confidence: 94%

Detection of recurrent cervical cancer by whole-body FDG PET scans

Yang

Wang

Zhu

et al. 2008

Chin. J. Clin. Oncol.

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“…Several authors have investigated the usefulness of PET for postoperative or post-therapy surveillance of patients with cervical cancer and found that the sensitivity, specificity, and accuracy were 86-100%, 60-94%, and 70-97%, respectively (Table 4) [12][13][14][15][16][17][18][19]. These studies revealed that false-negative cases included local recurrence in the retrovesical region, pelvic recurrence, lung metastasis, peritoneal dissemination, pelvic LN metastasis, and para-aortic LN metastasis, whereas false-positive cases were due to inflammatory lesions, physiological uptake, and postoperative change.…”

Section: Discussionmentioning

confidence: 97%

“…There have been several studies of FDG-PET [12][13][14][15][16][17][18][19] and only two reports of integrated FDG-PET/CT [20,21] describing their usefulness for the diagnosis of recurrent uterine cervical cancers. Chung et al [20] and Sironi et al [21] discussed the diagnostic accuracy of PET/CT, but did not compare PET/CT interpretation with PET-alone interpretation.…”

Section: Introductionmentioning

confidence: 99%

Performance of FDG-PET/CT for diagnosis of recurrent uterine cervical cancer

et al. 2008

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The purpose is to evaluate the accuracy of integrated FDG-PET/CT, compared with PET alone, for diagnosis of suspected recurrence of uterine cervical cancer. Fifty-two women who had undergone treatment for histopathologically proven cervical cancer received PET/CT with suspected recurrence. PET-alone and integrated PET/CT images were evaluated by two different experienced radiologists by consensus for each investigation. A final diagnosis was confirmed by histopathology, radiological imaging, and clinical follow-up for over 1 year. Patient-based analysis showed that the sensitivity, specificity, and accuracy of PET/CT were 92.0% (23/25), 92.6% (25/27), and 92.3% (48/52), respectively, while for PET, the corresponding figures were 80.0% (20/25), 77.8% (21/27), and 78.8% (41/52), respectively. PET/CT resolved the false-positive PET results due to hypermetabolic activity of benign/inflammatory lesions and physiological variants, and was able to detect lung metastasis, local recurrence, peritoneal dissemination, para-aortic lymph node metastasis, and pelvic lymph node metastasis missed by PET alone. However, tiny local recurrence and lymph node metastasis could not be detected even by PET/CT. FDG-PET/CT is a useful complementary modality for providing good anatomic and functional localization of sites of recurrence during follow-up of patients with cervical cancer.

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“…PET scan is superior in the detection of lymph node metastasis compared to conventional imaging [27][28][29]. Patz et al evaluated a variety of focal pulmonary abnormalities by using a FDG PET, and determined a threshold of standardized uptake ratio (SUR) of 2.5 for optimal sensitivity and specificity of benign lesions.…”

Section: Discussionmentioning

confidence: 99%