Diagnosis of retinoblastoma by fine‐needle aspiration and aqueous cytology

Das, Dilip K.; Das, Jayachandra; Chachra, Krishan Lal; Natarajan, Radha

doi:10.1002/dc.2840050217

Cited by 14 publications

(14 citation statements)

References 10 publications

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“…Tight cohesion and nuclear molding among the tumor cells are distinct cytologic features. There are limited studies on FNAC of retinoblastoma. Sen et al described FNAC of three cases of retinoblastoma.…”

Section: Malignant Neoplasm Of Eyelidmentioning

confidence: 99%

“…They did not notice any rosettes on cytology smear in these three cases. However, Flexner‐Wintersteiner rosettes and Homer‐Wright rosettes have been described by several authors . Flexner‐Wintersteiner rosettes are seen as cells around the lumen, whereas in case of Homer‐Wright rosettes, the cells are arranged around cobweb‐like material.…”

Section: Malignant Neoplasm Of Eyelidmentioning

confidence: 99%

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Fine‐needle aspiration cytology of orbital and eyelid lesions

Agrawal

Dey

Lal

2013

Diagnostic Cytopathology

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Fine-needle aspiration cytology (FNAC) of orbital lesions is now increasingly popular. Because of its unique location and the occurrence of varieties of lesions, diagnosis of orbital lesion is a challenge to the cytopathologists. FNAC of orbital and eyelid tumors is a suitable diagnostic technique that necessitates close co-operation between the ophthalmologist and pathologist. No radical procedure should be planned on the basis of FNAC, but it allows the diagnosis of a new primary lesion or the recurrence or metastasis of a tumor and can be done to identify lesions that require either specific medical therapy, as in nonresectable, inflammatory, and lymphoid tumors, or limited surgery for benign resectable neoplasms. With the help of various ancillary techniques a definitive diagnosis is possible on orbital and adnexal lesions. It is essential to have a detailed knowledge on the FNAC of these lesions and their potential pitfalls. In this present review, we have discussed various orbital lesions, their clinical presentations, cytomorphology, and ancillary techniques to confirm the diagnosis.

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Section: Malignant Neoplasm Of Eyelidmentioning

confidence: 99%

Section: Malignant Neoplasm Of Eyelidmentioning

confidence: 99%

Fine‐needle aspiration cytology of orbital and eyelid lesions

Agrawal

Dey

Lal

2013

Diagnostic Cytopathology

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“…Finally, retinoblastoma can be difficult to distinguish from medulloepithelioma, another rare childhood ocular tumor. 29,35 In practice, these two entities are correctly recognized by ophthalmologists since medulloepithelioma characteristically arises from the ciliary body in comparison to retinoblastoma which arises from the retina. 29 In addition to the late onset, the absence of an intra-ocular mass clinically in the current case made the diagnosis of a neoplastic lesion in the cytology specimen more challenging.…”

Section: Discussionmentioning

confidence: 98%

Cytopathological diagnosis of adult retinoblastoma in a vitrectomy specimen

Orellana¹,

Brimo²,

Auger³

et al. 2009

Diagnostic Cytopathology

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Retinoblastoma (RB) is extremely rare in adults. We describe a case of RB diagnosed by cytology in a vitrectomy specimen of a 23-year-old patient who presented with diminished visual acuity and retinal detachment in the absence of a clinically-visible mass. Cytological examination of the vitreous fluid showed clusters of loosely cohesive atypical cells with high nuclear to cytoplasmic ratio and "salt and pepper" chromatin pattern in a background of normal neuronal retinal cells. Nuclear molding was present as well as numerous apoptotic bodies. The cells were focally positive for epithelial markers and showed strong and diffuse positivity for neuroendocrine markers. Ki-67 stained 90% of the "atypical cells" nuclei, in contrast to nonneoplastic retinal neuronal cells, which were negative for the marker. A diagnosis of RB was rendered, and subsequently was confirmed in the enucleation specimen. The cytological differential diagnosis is discussed as well as the role that cytology and immunohistochemistry can play in differentiating neoplastic cells from normal retinal cellular elements in vitreous fluid specimens.

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“…When we consider the high sensitivity of MLGAPC in retinoblastoma, MLGAPC immunohistochemistry may be a quite useful tool for the pathological diagnosis of fine‐needle aspiration of orbital tumours 30 , 31 …”

Section: Discussionmentioning

confidence: 99%