Diagnosis of rheumatoid arthritis using light: correction of motion artefacts and color visualization of multispectral images

The aim of this study was to proof applicability of hyperspectral imaging for the analysis and classification of human mucosal surfaces in vivo. The larynx as a prototypical anatomically well-defined surgical test area was analyzed by microlaryngoscopy with a polychromatic lightsource and a synchronous triggered monochromatic CCD-camera. Image stacks (5 benign, 7 malignant tumors) were analyzed by established software (principal component analysis PCA, hyperspectral classification, spectral profiles). Hyperspectral image datacubes were analyzed and classified by conventional software. In PCA, images at 590-680 nm loaded most onto the first PC which typically contained 95% of the total information. Hyperspectral classification clustered the data highlighting altered mucosa. The spectral profiles clearly differed between the different groups. Hyperspectral imaging can be applied to mucosal surfaces. This approach opens the way to analyze spectral characteristics of histologically different lesions in order to build up a spectral library and to allow non-touch optical biopsy.

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Hyperspectral imaging of mucosal surfaces in patients

Gerstner

Laffers

Bootz

et al. 2012

Journal of Biophotonics

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Registration of scattered laser images and radiographs of small finger joints

Zabaryło

Grozdanovic

Backhaus

et al. 2013

Photonics &Amp; Lasers in Medicine

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Image processing methods for the registration of scattered light pictures and X-ray radiographs can improve the diagnostic yield of rheumatoid joints as compared to a separate interpretation of radiographs and optical images. The image fusion described uses thin plate spline interpolation techniques. This article also describes the image pre-processing techniques necessary to identify intrinsic landmarks that are a prerequisite for a point-based registration technique.

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Comparison of Photo Optical Imaging with Musculoskeletal Ultrasound and Clinical Examination in the Assessment of Inflammatory Activity in Proximal Interphalangeal Joints in Rheumatoid Arthritis and Osteoarthritis

Amitai

Werner

Schicke³

et al. 2015

J Rheumatol

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Diagnosis of rheumatoid arthritis using light: correction of motion artefacts and color visualization of multispectral images

Cited by 3 publications

References 10 publications

Hyperspectral imaging of mucosal surfaces in patients

Hyperspectral imaging of mucosal surfaces in patients

Registration of scattered laser images and radiographs of small finger joints

Comparison of Photo Optical Imaging with Musculoskeletal Ultrasound and Clinical Examination in the Assessment of Inflammatory Activity in Proximal Interphalangeal Joints in Rheumatoid Arthritis and Osteoarthritis

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