Diagnosis of <scp>Guillain‐Barré</scp> syndrome and validation of the Brighton criteria in Malaysia

Tan, Cheng‐Yin; Razali, Siti Nur Omaira; Goh, Kim‐Leng; Shahrizaila, Nortina

doi:10.1111/jns.12398

Cited by 9 publications

(8 citation statements)

References 36 publications

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“…9,10,41,42 In the Malaysian study by Chen et al regarding the validity of the Brighton criteria in GBS patients, the highest level of diagnostic certainty (Level 1) was achieved in 67% of patients, followed by 25% at Level 2, 4% at Level 3 and 5% at Level 4. 21 The findings in Malaysia are comparable to studies from the Netherlands where Level 1 diagnostic certainty was achieved in 61% of their adult GBS population. 10,21 High diagnostic rates have been reported in GBS cohorts in Bangladesh and China, where level 1 was achieved in 91% and 79% of patients, respectively.…”

Section: Discussionsupporting

confidence: 73%

“…21 The findings in Malaysia are comparable to studies from the Netherlands where Level 1 diagnostic certainty was achieved in 61% of their adult GBS population. 10,21 High diagnostic rates have been reported in GBS cohorts in Bangladesh and China, where level 1 was achieved in 91% and 79% of patients, respectively. 42,43 There are several reasons for this difference.…”

Section: Discussionsupporting

confidence: 73%

“…41 Neuroelectrophysiological examination and CSF examination were positively correlated with the diagnostic certainty level of the Brighton criteria (P < 0.01). 21 When the Brighton criteria and the National Institute of Neurological Disorders and Stroke (NINDS) were compared in a cohort analysis, a diagnostic certainty of at least Level 3 of the Brighton criteria (95 percent) exhibited a sensitivity comparable to the NINDS criteria. 22 The sensitivity of the Brighton criteria in the GBS patient population has been studied in numerous research.…”

Section: Discussionmentioning

confidence: 99%

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Profile Of Children With Guillan Barre Syndrome In RSUP Haji Adam Malik Medan: Events In 5 Years

H¹,

Dimyati²,

Hasibuan³

2021

IJRP

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Background : Guillain-Barré syndrome (GBS) is an acute demyelinating disease of the peripheral nervous system characterized clinically by flaccid paralysis. The mortality rate in children is about 3-5%. Early diagnosis and therapy important for patient's prognosis. Objective : The aim of this study was to acquaint the profile of children with Guillain-Barré syndrome at the RSUP HAM Medan Hospital from 2016 to 2020. Methods : This study is a descriptive study with a retrospective design. The population and sample with total sampling of the children with GBS diagnosed at the HAM Medan Hospital recorded in the medical record from January 2016 to December 2020. The data were analyzed univariately and presented with a frequency distribution. Results: From this study, 41 children with GBS were found. There were 18 children (43.9%) with age between 10-14 year (female was 22 people (53.7%). Based on the Brighton Criteria for GBS children, most of the children was on level 2 that were 35 people (85 ,4%). From the results of the EMG (Electromyography) examination in GBS children, 24 people (58.5%). had the most types of GBS were Acute Motor Axonal Neuropathy (AMAN). There was no cytoalbumin dissociation was found on CSF analysis. Mostly 28 people had supportive therapy, that was the most used type of therapy. The disability scale shows that children who can walk with the help of a cane or supporting equipment (disability scale 3) was 26 people (63.4%). Based on the length of stay in the hospital, 26 children (63.4%) were treated for 8-14 days. Conclusion: Majority the case of GBS in the RSUP HAM Medan was similar previous studies. Our results can be used as baseline data for understanding the characteristics of GBS in Indonesia.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Profile Of Children With Guillan Barre Syndrome In RSUP Haji Adam Malik Medan: Events In 5 Years

H¹,

Dimyati²,

Hasibuan³

2021

IJRP

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“…13 Cases with MFS where the complete triad of ophthalmoplegia, ataxia, and areflexia was not present were classified as level 4. 95 Cases with other variants such as facial diplegia with paresthesia, PCB variant, and pure sensory GBS has been excluded. Accordingly, 51 cases have fulfilled level 1 of diagnostic certainty, 26 cases have fulfilled level 2, 7 cases have fulfilled level 3, and 9 cases fulfilled level 4.…”

Section: Resultsmentioning

confidence: 99%

Guillain Barre Syndrome as a Complication of COVID-19: A Systematic Review

Aladawi

Elfil

Abu-Esheh

et al. 2021

Can. J. Neurol. Sci.

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Background: In January 2020, the first case of Guillain Barre syndrome (GBS) due to COVID-19 was documented in China. GBS is known to be postinfectious following several types of infections. Although causality can only be proven through large epidemiological studies, we intended to study this association by a thorough review of the literature. Methods: We searched PubMed, EMBASE, and Google scholar and included all papers with English or Spanish full text and original data of patients with GBS and recent COVID infection. Variables of interest were demographics, diagnostic investigations, and the latency between arboviral and neurological symptoms. Further variables were pooled to identify GBS clinical and electrophysiological variants, used treatments, and outcomes. The certainty of GBS diagnosis was verified using Brighton criteria. Results: We identified a total of 109 GBS cases. Ninety-nine cases had confirmed COVID-19 infection with an average age of 56.07 years. The average latency period between the arboviral symptoms and neurologic manifestations for confirmed COVID-19 cases was 12.2 d. The predominant GBS clinical and electromyography variants were the classical sensorimotor GBS and acute demyelinating polyneuropathy respectively. Forty cases required intensive care, 33 cases required mechanical ventilation, and 6 cases were complicated by death. Conclusions: Studies on COVID-19-related GBS commonly reported sensorimotor demyelinating GBS with frequent facial palsy. The time between the onset of infectious and neurological symptoms suggests a postinfectious mechanism. Early diagnosis of GBS in COVID-19 patients is important as it might be associated with a severe disease course requiring intensive care and mechanical ventilation.

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“…However, diagnosing GBS according to the Brighton criteria requires cerebrospinal fluid (CSF) investigations and demonstration of a dissociation cyto-albuminique (DCA). 2 Unfortunately, CSF investigations were not carried out, so the diagnosis of GBS remains questionable.…”

mentioning

confidence: 99%