Diagnosis of Simultaneous Multiple Gastric Cancers by the Endoscopic Congo Red - Methylene Blue Test

Tatsuta, M; Okuda, S.

doi:10.1055/s-2007-1018137

Cited by 30 publications

(17 citation statements)

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“…The most reliable study was that reported by Kosaka et al [2] , in which all the stomach specimens, 68 patients with gastric cancer were subjected to a serial histological examinations after operations, and accessory lesions were revealed in five (7.4%) cases. In the present study, we observed that SMGC were present in 5.1% of all patients with gastric cancer, that is lower than those reported in previous investigations [10][11][12][13][14] .…”

Section: Discussioncontrasting

confidence: 76%

Clinicopathological characteristics of synchronous multiple gastric cancers in Chinese: An analysis of 44 cases

Zhang

Liu

Yang

et al. 2009

Chin. J. Cancer Res.

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Objective: To investigate the clinicopathologic characteristics of the primary synchronous multiple gastric cancers (SMGC) in Chinese.Methods: Clinicopathologic data of patients with histologically confirmed gastric cancer who received surgical operations in our department between 1993 and 2002 were retrospectively collected and analyzed. Clinicopathologic characteristics including gender, age, tumor location, differentiation and staging between patients with SMGC and those with solitary gastric cancer (SGC) were compared. Synchronous multiple and solitary gastric cancers were diagnosed and classified based on radiography upper endoscopy and histology. All the cases were followed up after the operation and 5-year survival rate between the two groups was compared.Results: A total of 871 patients with gastric cancer were included. Synchronous multiple gastric cancers were found in 44 (5.1%) of these cases. More of the diagnose in the early stage to SMGC than to SGC. SMGC were more likely to be located at the lower third stomach and of a low grade differentiation, compared to SGC. However, there were no significant differences in the rates of lymph node metastasis and lymphatic vessel invasion between multiple and solitary gastric cancers. In addition, the 5-year survival rate did not difference between the two groups.Conclusion: The whole stomach should be detected carefully to avoid missing out the multiple gastric cancers. Concerning the treatment of multiple gastric cancer, the sufficient extent of the stomach wall resection was necessary, and the extent of lymphadenectomy was supposed to follow the operation for the solitary gastric cancer according to the staging of the cancer lesions.

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Section: Discussioncontrasting

confidence: 76%

Clinicopathological characteristics of synchronous multiple gastric cancers in Chinese: An analysis of 44 cases

Zhang

Liu

Yang

et al. 2009

Chin. J. Cancer Res.

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“…The surgeon can identify the F-line during operation by the Congo red test, or can estimate more easily only by the appearance of the mucosal folds. 15 …”

Section: Discussionmentioning

confidence: 99%

A clinicopathologic study on multiple gastric cancers with special reference to distal gastrectomy

Kosaka

Miwa

Yonemura

et al. 1990

Cancer

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Simultaneous multiple gastric cancer was seen in 49 (5.8%) of 852 resected stomachs. Patients with multiple cancers were older than those with single gastric cancers ( P < 0.01) and the incidence of multiple gastric cancer was significantly higher in male patients than in female patients ( P < 0.05). The incidence rates of multiple carcinomas were 9.6% of early gastric carcinomas and 4.0% of advanced gastric carcinomas. With regard to histologic type, the incidence rate of the differentiated type was 71% and the incidence rate of the undifferentiated type was 29%. In 68 serially resected stomachs, 5 (7.4%) new multiple cancers were detected microscopically, whereas 4 (5.9%) had already been diagnosed grossly. The incidence rate of multiple carcinoma increased to 13.2% by this procedure. The cases that were cut serially showed that most of the multiple cancers were located distally from the F-line presenting the line along which intestinal metaplasia appeared. This study suggests that the surgeon is required to resect the area including the F-line at the time of distal gastrectomy so as noi to leave another cancer in the gastric remnant. Cancer 65:2602-2605,1990.ITH RECENT ADVANCES and improvement in gas-W trofiberoptic endoscopy, the number of multiple gastric cancers appears to have increased.'-' Kidokoro et u1.: who evaluated 6 13 carcinomas of the gastric remnant, showed that 27.6% (75 of 272) of the patients who underwent the initial surgery due to benign disease had new gastric cancer within 10 years after the surgery and that 84.9% (219 of 258) who underwent gastrectomy due to gastric cancer had another cancer within 10 years. The latter group seemed to include both multiple synchronous gastric cancers that were overlooked at the initial surgery and multiple metachronous gastric cancers that developed after the initial gastrectomy. Therefore, the study of multiple gastric cancer is of utmost importance in the manFrom the 2nd Department of Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan.Address for reprints: Takeo Kosaka, MD, 2nd Department of Surgery, School of Medicine, Kanazawa University, 13-1, Takara-machi, Kanazawa, 920, Japan.Accepted for publication December 6 , 1989. agement of cancer of the gastric remnant and in the epidemiology and histogenesis of gastric cancer.In this study, we examined simultaneous multiple gastric cancers clinicopathologically and serially cut stomachs microscopically to determine the high risk group for multiple gastric cancer and to establish a guide to appropriate gastrectom y. Materials and MethodsWe studied 49 patients who had simultaneous multiple gastric carcinomas and who were operated on at the 2nd

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“…The classification system had the specificity and NPV of 81% and 99%, respectively, to diagnose dysplasia. Congo red alone, or combined with methylene blue, has also been applied in chromoendoscopy [132, 133]. The correct diagnosis of synchronous multiple loci of EGC by Congo red-methylene blue chromoendoscopy could be higher than that of conventional WLI endoscopy (28.3% versus 88.9%) [133].…”

Section: The Application Of Iee In Stomachmentioning

confidence: 99%

Screening for Precancerous Lesions of Upper Gastrointestinal Tract: From the Endoscopists' Viewpoint

Chung

Wang²

2013

Gastroenterology Research and Practice

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Upper gastrointestinal tract cancers are one of the most important leading causes of cancer death worldwide. Diagnosis at late stages always brings about poor outcome of these malignancies. The early detection of precancerous or early cancerous lesions of gastrointestinal tract is therefore of utmost importance to improve the overall outcome and maintain a good quality of life of patients. The desire of endoscopists to visualize the invisibles under conventional white-light endoscopy has accelerated the advancements in endoscopy technologies. Nowadays, image-enhanced endoscopy which utilizes optical- or dye-based contrasting techniques has been widely applied in endoscopic screening program of gastrointestinal tract malignancies. These contrasting endoscopic technologies not only improve the visualization of early foci missed by conventional endoscopy, but also gain the insight of histopathology and tumor invasiveness, that is so-called optical biopsy. Here, we will review the application of advanced endoscopy technique in screening program of upper gastrointestinal tract cancers.

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Diagnosis of Simultaneous Multiple Gastric Cancers by the Endoscopic Congo Red - Methylene Blue Test

Cited by 30 publications

References 0 publications

Clinicopathological characteristics of synchronous multiple gastric cancers in Chinese: An analysis of 44 cases

Clinicopathological characteristics of synchronous multiple gastric cancers in Chinese: An analysis of 44 cases

A clinicopathologic study on multiple gastric cancers with special reference to distal gastrectomy

Screening for Precancerous Lesions of Upper Gastrointestinal Tract: From the Endoscopists' Viewpoint

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