Diagnosis of smear-negative pulmonary tuberculosis based on clinical signs in the Republic of Congo

Linguissi, Laure Stella Ghoma; Vouvoungui, Christevy; Poulain, Pierre; Essassa, Gaston Bango; Kwedi, Sylvie; Ntoumi, Francine

doi:10.1186/s13104-015-1774-8

Cited by 22 publications

(22 citation statements)

References 25 publications

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“…Particular attention should be paid to the diagnosis of sputum negative TB. In areas with a higher prevalence of TB and HIV, the clinical signs and inexpensive tests, such as direct microscopy, tuberculin skin test and chest radiography, are of great importance in the diagnosis of PTB 29,30 . Anorexia, asthenia and a less persistent cough are good predictors of SNPT.…”

Section: Discussionmentioning

confidence: 99%

“…These symptoms thus deserve to be recommended as indicators of the SNPT diagnosis within an ATB dispensary. This strategy can help reduce morbidity and mortality associated with a late SNPT diagnosis 30 . Sputumnegative TB was present in 40% of those affected in Northern Kosovo, which is consistent with the results of other studies 5,15,30,31 , while the atypical radiographic changes occurred in 23% of the affected.…”

Section: Discussionmentioning

confidence: 99%

“…Rezultati. Od tuberkuloze pluća češće su obolevali muškarci, starosti 30-39 godina (OR 6.08, 95 CI% 1, [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]84), uglavnom sa sela (p = 0,001), nižeg stepena obrazovanja (p = 0,031). Od pneumonije su češće obolevale ženske osobe starije od 60 godina (p = 0,012).…”

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Differences and similarities between the symptoms and clinical signs in patients with pulmonary tuberculosis and pneumonia

Smiljic

Radovic²,

Ilić

et al. 2019

VOJNOSANIT PREGL

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Background/Aim. Tuberculosis in the second decade of the 21st century is an infectious disease with the highest mortality rate. In addition, in developed countries, pneumonia is the major couse of morbidity and mortality in adults. The aim of our study was to point out the differences and similarities between symptoms, laboratory parameters and clinical indicators in patients with pulmonary tuberculosis (PTB) and patients with pneumonia in the general population and in people belonging to the high risk groups for developing tuberculosis. Methods. This prospective study included patients with PTB (n = 70) and pneumonia (n = 75) treated at the Pulmonology Department of Clinical Hospital Center in Kosovska Mitrovica. Results. PTB was more frequent in men, 30-39 years of age (OR; 6:08), mainly from rural areas (p = 0.001), and with lower levels of education (p = 0.031). Pneumonia was more frequent in women older than 60 years of age (p = 0.0012). Night sweats (p = 0.001) and weight loss (p = 0.062) were significantly more frequent in patients with PTB, while chest pain (p = 0.001) and high temperature (p = 0.036) were more common in patients with pneumonia. X-ray changes in patients with PTB were located in the upper fields (p = 0.001), or appeared to be bilateral (p = 0.004). The strongest predictor associated with an increased risk of night sweats was diagnosed PTB (OR = 30.0). The chest pain was a predictor of pneumonia, unilateral changes (OR = 4.65) in the lower lung fields (OR = 0.08). Conclusion. Night sweats, weight loss and chest X-ray abnormalities in upper fields were significant indicators of PTB. Chest pain, fever and chest X-ray abnormalities in lower fields were significant indicators of pneumonia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Differences and similarities between the symptoms and clinical signs in patients with pulmonary tuberculosis and pneumonia

Smiljic

Radovic²,

Ilić

et al. 2019

VOJNOSANIT PREGL

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“…Diagnosing a neglected disease like melioidosis with a similar clinical presentation like TB in this milieu is challenging for the treating physicians. Patients with a past history of TB are usually diagnosed as recurrence based on suggestive clinical presentations, indicative radiological findings and other non-confirmatory laboratory parameters (ADA profile, high ESR), rather by laboratory confirmation [15,16] and treated with anti-tubercular antibiotics. This may be considered as one of the major causes of misdiagnosis of melioidosis, as it is reflected in our observation of seven cases of melioidosis, who were suspected to have recurrent TB at primary health care settings.…”

Section: Discussionmentioning

confidence: 99%

Melioidosis In Suspected Recurrent Tuberculosis: A disease in disguise

Garg

Shaw

Vandana

et al. 2020

J Infect Dev Ctries

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Introduction: Melioidosis, caused by the soil saprophyte B. pseudomallei, is a ‘neglected’ infectious disease in many Asian countries. It remained undiagnosed or misdiagnosed in India for long due to a lack of awareness and facilities to diagnose the disease; however, it is slowly gaining the status of an emerging disease recently. The disease is well known as a great mimicker, as the presentations are very similar to many other tropical diseases, and more importantly, to tuberculosis . Methodology: A prospective observational study was conducted from January 2016 – December 2018 to find the occurance of melioidosis in patients with ‘recurrent’ tuberculosis infection in a tertiary health care hospital from southern India. All suspected cases of recurrent tuberculosis were simultaneously tested for the presence of B. pseudomallei, and basic demographics and clinical details were documented. Result: Among 11,138 patients admitted with suspected tuberculosis infection, 586 (5.2%) patients were confirmed. There was recurrent Mycobacterium tuberculosis infection in 11/586 (1.8%) cases, and 7/586 (1.2%) had growth of B. pseudomallei in culture. Patients with melioidosis had either pulmonary involvement, or bone and joint infections and deep abscesses. Uncontrolled diabetes mellitus was the major risk factor. Conclusion: The study foreshadows the need for prompt and accurate microbiological diagnosis along with a high index of suspicion from the clinicians in countries which are endemic for both melioidosis and tuberculosis, thus ameliorating the irrational anti-tuberculosis treatment.

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“…Posebnu pažnju treba obratiti u dijagnozi sputum negativne tuberkuloze. U područjima sa višom prevalencom TBC i HIV, klinički znaci i jeftina ispitivanja, kao što su direktna mikroskopija, tuberkulinski test i radiografija pluća su od velikog značaja u dijagnostici TBC [17]. Anoreksija, astenija i manje uporni kašalj su dobri prediktori SNTBC.…”

Section: Rezultatiunclassified

Sociodemographic and clinical characteristics of smear-positive and smear-negative pulmonary tuberculosis

Radovic¹

2017

Tim Med Glas

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ODELJENJE PULMOLOGIJE, KLINIČKO-BOLNIČKI CENTAR KOSOVSKA MITROVICA, SRBIJA Sažetak:Cilj našeg istraživanja bio je da prikažemo sociodemografske faktore i kliničke karakteristike kod obolelih od sputum negativne i sputum pozitivne tuberkuloze pluća. Metodologija: Prospektivnom studijom obuhvatili smo sve obolele od plućne tuberkuloze (N=43) lečene na odeljenju Pulmologije Kliničko-bolničkog centra u Kosovskoj Mitrovici u periodu od 2012. do 2014. godine. Rezultati: Od sputum negativne tuberkuloze lečeno je 15 (35%) obolelih. Sputum pozitivna tuberkuloza pluća bila je značajno češća kod osoba mlađe životne dobi (p=0.05), dok su osobe koje su starije od 50 godina podjednako obolevale od sputum pozitivne ili sputum negativne tuberkuloze. U odnosu na pol, mesto stanovanja i porodični status nije bilo razlike između obolelih. Značajno više obolelih od sputum negativne tuberkuloze pluća bilo je nižeg stepena obrazovanja (p<0.001). Kašalj i iskašljavanje su podjednako bili česti. Hemoptizije su bile ćešće kod sputum pozitivne tuberkuloze pluća (p=0.08). Noćno znojenje i malaksalost bili su jednako česti kod obe grupe obolelih. Anemija je bila značajno češča kod sputum negativne tuberkuloze (p=0.037). Nije postojala značajna razlika u radiografskim promenama između sputum negativne tuberkuloze i sputum pozitivne tuberkuloze pluća. Pridružene bolesti su jednako bile zastupljene kod obe grupe obolelih, osim hronične opstruktivne bolesti pluća od koje su češće bolovali pacijenti sa sputum pozitivnom tuberkulozom. Zaključak: Sputum negativna tuberkuloza pluća je bila zastupljena kod oko jedne trećine obolelih od tuberkuloze i češće su bolovale osobe starije od 50 godina sa nižim stepenom obrazovanja. Anemija je bila izražena kod sputum negativne tuberkuloze. Hemoptizije i hronična opstruktivna bolest pluća su bili češći kod sputum pozitivne tuberkuloze. Ključne reči: sputum negativna tuberkuloza pluća, sociodemografski faktori, kliničke karakteristike Summary: The aim of our study was to show socio-demographic factors and clinical characteristics in patients with smear negative and smear positive pulmonary tuberculosis. Methodology: The prospective study included all patients with Pulmonary tuberculosis (N = 43) treated at the Pulmonology Department of the Clinical Hospital Center in Kosovska Mitrovica during the study period 2012-2014. Results: 15 (35%) patients were treated for smear negative tuberculosis. Smear positive pulmonary tuberculosis was significantly more common in younger population (p = 0.05), while people above age 50 were equally infected with both smear positive and smear negative pulmonary tuberculosis. In relation to gender, place of residence and marital status there was no difference between the patients. Significantly more patients with smear negative pulmonary tuberculosis had lower level of education (p <0.001). Cough and expectoration were equally frequent. Hemoptysis was more likely in smear positive pulmonary tuberculosis (p = 0.08). Night sweats and exhaustion were equally present in both groups ...

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Diagnosis of smear-negative pulmonary tuberculosis based on clinical signs in the Republic of Congo

Cited by 22 publications

References 25 publications

Differences and similarities between the symptoms and clinical signs in patients with pulmonary tuberculosis and pneumonia

Differences and similarities between the symptoms and clinical signs in patients with pulmonary tuberculosis and pneumonia

Melioidosis In Suspected Recurrent Tuberculosis: A disease in disguise

Sociodemographic and clinical characteristics of smear-positive and smear-negative pulmonary tuberculosis

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