Diagnosis of soft tissue tumours by Tru-Cut® biopsy

Ball, Adrian; Fisher, Cyril; Pittam, M.; Watkins, Rebecca; Westbury, G

doi:10.1002/bjs.1800770713

Cited by 133 publications

(69 citation statements)

References 4 publications

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“…In that respect, the results of our study appear disappointing at first sight. Recent studies have reported excellent results of large core needle biopsies with a reported sensitivity ranging between 90-95% [2,3,5,8], but in the present study large core needle biopsies were still less often used M A N U S C R I P T…”

Section: Use and Yield Of The Various Pathology Techniquescontrasting

confidence: 52%

“…The aforementioned good results of core needle biopsies come from referral centers [2,[12][13][14], where there is vast experience with sarcoma treatment and hence with the diagnostic work-up too. The limited sensitivity of needle biopsies in the present population based cohort is most likely explained by less experience with the collection of specimens, and less experience with the evaluation of the retrieved material.…”

Section: A C C E P T E D Article In Pressmentioning

confidence: 99%

“…[1] Several studies have documented good results with less invasive diagnostic procedures like large core needle biopsy (CNB), reporting a sensitivity of core needle biopsies of approximately 95 percent. [2][3][4][5] Therefore core needle biopsies has become equally acceptable in the last 15 years. Some authors even advocate the use of fine needle aspiration (FNA).…”

Section: Introductionmentioning

confidence: 99%

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Current pathology work-up of extremity soft tissue sarcomas, evaluation of the validity of different techniques

Verheijen

Witjes

Gorp

et al. 2010

European Journal of Surgical Oncology (EJSO)

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Objective: In patients with extremity soft tissue sarcomas (STS) a correct histopathological diagnosis is considered important before surgical treatment. We evaluated the preoperative use and sensitivity of the various pathology techniques. Methods:In a population based study in patients operated for a newly diagnosed extremity STS between January 2000 and December 2003 the preoperative pathology work-up was evaluated. Data were retrieved from a national pathology database (PALGA). The sensitivity of the three techniques was assessed considering an examination affirmative when the conclusion of the pathology report stated the presence of mesenchymal malignancy.Results: The pathology reports of 573 patients were identified in the database. In 177 patients (31%) no pathology examination was done before resection of the tumour. In the remaining 396 patients the pathology procedure of first choice had been an incisional biopsy (IB) in 195 patients (49 percent), a core needle biopsy (CNB) in 90 patients (23 percent) and a fine needle aspiration (FNA) in 111 patients (28 percent). An affirmative diagnosis was established in 95% of the patients following an IB, in 78% after a CNB and in 38% following FNA. After an initial CNB an additional IB was performed in 18 of the 90 patients improving the yield to 89% After an initial FNA a subsequent histological biopsy was done in 53 of the 111 patients, increasing the sensitivity to 71%. Conclusions:In this population based study in patients treated for extremity STS, the proportion of patients operated without preoperative pathology evaluation was high. In the remaining patients an incisional biopsy was still the most commonly performed technique with the highest yield.

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Section: Use and Yield Of The Various Pathology Techniquescontrasting

confidence: 52%

Section: A C C E P T E D Article In Pressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Current pathology work-up of extremity soft tissue sarcomas, evaluation of the validity of different techniques

Verheijen

Witjes

Gorp

et al. 2010

European Journal of Surgical Oncology (EJSO)

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“…In most cases, a core needle biopsy is adequate to obtain diagnostic tissue, and the accuracy of core needle biopsies is excellent, with a high sensitivity and specificity [21][22][23]. Combined with low morbidity, this is the diagnostic procedure of choice.…”

Section: Evaluation and Managementmentioning

confidence: 99%

Pediatric Soft Tissue Sarcomas

Loeb

Thornton

Shokek

2008

Surgical Clinics of North America

110

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Soft tissue sarcomas in children are relatively rare. Approximately 850 to 900 children and adolescents are diagnosed each year with rhabdomyosarcoma (RMS) or one of the non-RMS soft tissue sarcomas (NRSTS). Of these, 350 are cases of RMS. RMS is the most common soft tissue sarcoma in children 14 years old and younger, and NRSTS is more common in adolescents and young adults. Infants also get NRSTS, but their tumors constitute a distinctive set of histologies, including infantile fibrosarcoma and malignant hemangiopericytoma, not seen in adolescents. Surgery is a major therapeutic modality for all pediatric soft tissue sarcomas, and radiation can play a role in the local therapy for these tumors. RMS is always treated with adjuvant chemotherapy, whereas chemotherapy is reserved for the subset of NRSTS that are high grade or unresectable. This review discusses the etiology, biology, and treatment of pediatric soft tissue sarcomas, including new approaches to therapy aimed at improving the dismal prognosis of patients who have recurrent and metastatic disease. Rhabdomyosarcoma EpidemiologyRMS is the most common soft tissue sarcoma among children less than 15 years old, with an incidence of 4.6 per million per year [1]. This represents 50% of all soft tissue sarcomas in this age range. It is slightly more common in boys than in girls, with a ratio of 1. slightly more common in white children than in black children less than 5 years old (1.1:1) but is more common in black children than in white children 5 years of age or older (1.2:1). Over the past 30 years, the incidence of RMS in the pediatric age group has been constant [1]. EtiologyLittle is known about the etiology of RMS. A few cases are associated with Li-Fraumeni syndrome (caused by germline mutations in p53) [2] or with neurofibromatosis (caused by mutations in NF1) [3]. There also is a weak association with congenital anomalies, especially in boys [4]. These tumors sometimes are seen as second malignant neoplasms after radiation therapy. Molecular and cellular biologyThere are two major histologic variants of RMS-embryonal and alveolar. Other, minor, histologic types include spindle cell, botryoid, and pleomorphic. Embryonal RMS is named for its resemblance to immature skeletal muscle, accounts for 60% of RMS cases in patients less than 20 years of age, and tends to arise in the head and neck region, orbits, and genitourinary region (including bladder and prostate). Alveolar RMS, named for its resemblance to normal lung parenchyma, arises predominantly in the head and neck region and the extremities [3]. Histologically, RMS is a small round blue cell tumor, characterized by expression of muscle-specific antigens, such as desmin and MyoD, and by the presence of eosinophilic rhabdomyoblasts on standard pathologic staining.Alveolar RMS is characterized by the presence of one of two recurrent chromosomal translocations: t(2;13)(q35;q14), seen in 55% of cases, or t(1;13)(p36;q14), seen in 22% of cases [5]. These fuse the FKHR gene on chromosome 13 with...

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“…In response to this critical need for a specific diagnosis, some investigators are using core needle biopsy, both alone or concurrently with FNA, in an attempt to improve sensitivity and specificity. 1, [23][24][25] Determination of the specific type of sarcoma is often complex and difficult even after surgical material is available. 26,27 This report investigates the role FNA plays in the evaluation of patients with sarcoma at one institution.…”

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confidence: 99%