Diagnosis of Urinary-Tract Infection in General Practice

Dove, G. A.; Bailey, A; Gower, P. E.; Roberts, Adrienne; Wardener, H. E. de

doi:10.1016/s0140-6736(72)92652-9

Cited by 30 publications

(7 citation statements)

References 9 publications

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“…For instance, Gallagher, Montgomerie, and North (1965) expressed surprise on finding that 'coagulase-negative staphylococci', at 14%, were the second most common pathogen in bacteriologically proven cases of urinary tract infection in general practice. Subsequently Dove, Bailey, Gower, Roberts, and de Wardener (1972) Table The distribution of types of Gram-positive, catalase-positive, coagulase-negative cocci isolated in significant numbers from the urine ofpatients submittedfor examination because they were thought to have urinary tract infections "Hospital patients in italic, those from general practice in ordinary type. Types according to Baird-Parker (1965 and with the following additions: i/L lactose-negative type 1 strains; I/P Phosphatase-negative type 1 strains; 4/A type 4 strains which produce acid anaerobically from mannitol; ?…”

Section: Discussionmentioning

confidence: 99%

Coagulase-negative staphylococci and micrococci in urinary tract infections.

Meers¹,

Whyte²,

Sandys³

1975

J Clin Pathol

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SYNPOSIS One hundred catalase-positive, coagulase-negative, Gram-positive cocci isolated in significant numbers from the urine of patients with urinary tract infections, provisionally subdivided by their sensitivity to novobiocin, were classified according to a slightly modified version of BairdParker's schemes (1965 and 1972). It appeared that strains of Micrococcus were nearly all of subgroup 3, and that these were important pathogens of young women presenting with urinary infections in general practice. All such strains were resistant to novobiocin. Strains of Staphylococcus were heterogeneous, and were found principally in infections arising in hospital, among older people. Most staphylococci were sensitive to novobiocin.It is suggested that it is easy and-sufficiently accurate to separate staphylococci and micrococci isolated from cases of urinary tract infection on the basis of their sensitivity or resistance to novobiocin. The distinction is useful because of its therapeutic and epidemiological significance.

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Section: Discussionmentioning

confidence: 99%

Coagulase-negative staphylococci and micrococci in urinary tract infections.

Meers¹,

Whyte²,

Sandys³

1975

J Clin Pathol

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“…Others (Gallagher, Montgomerie & North, 1965;Mond, Percival, Williams & Brumfitt, 1965;Steensberg et al 1969;Brooks & Maudar, 1972;Dove et at. 1972) have noted ratios of about 1-to-1 in smaller series where repeat examinations were excluded and in which there was likely to have been critical patient selection.…”

Section: Discussionmentioning

confidence: 99%

“…The position of Proteus spp. as the second most common organism isolated in urinary tract infections is usual (Loudon & Greenhalgh, 1962;Gallagher et al 1965;Mond et al 1965;McAllister et al 1971) except in the series where selection of patients by age and sex or by source has been such as to impose a different pattern (Steensberg et al 1969;Dove et al 1972). …”

Section: Discussionmentioning

confidence: 99%

“…For instance, one group found that 4 06% of 1556 causal organisms isolated from cases of urinary tract infection were Grampositive (Arneil, McAllister & Kay, 1973); in making this statement the authors appear to be referring to a contribution to a collaborative study (McAllister et al 1971) in which these Gram-positive organisms are given as Streptococcus faecalis 4 0 % and Staphylococcus aureus 0-06 %, with no isolations of coagulase-negative staphylococci. At the other end of the scale another group report that 24% of 55 organisms isolated from urine obtained by suprapubic aspiration from women aged between 16 and 60 were coagulase-negative staphylococci (Dove et al 1972). This figure is notable, because it is almost identical with that which can be derived from Table 4 when infections due to Staph.…”

Section: Discussionmentioning

confidence: 99%

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The bacteriological examination of urine: a computer-aided study

Meers

1974

J. Hyg.

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SUMMARYFor 6 months details of every patient who had his or her urine sent to a laboratory for bacteriological examination and the result of such examination were entered on a computer-card. A total of 15,606 cards were completed with information in code recording the sex and age of a patient, the origin of the request, the presence or absence in the urine of an excess of protein or cells, the culture result and the name of any significant organism isolated together with its sensitivity to various antimicrobial drugs. This information was interrelated in a computer, and in some cases the resulting numerical details were expressed as rates so as to eliminate the effect of uneven sex and age distribution. In this waythe occurrence ofurinary tract infection and the type of infecting organism in persons of either sex at various ages was examined according to whether the patient was in hospital or general practice. The sensitivity pattern of each type of significant organism isolated was established according to its source. The association between patients of either sex and various ages who had, or did not have, bacteriologically evident infections and the presence in their urine of an inflammatory exudate was investigated. Finally, the capacity of each type of infecting organism to produce such an exudate was estimated.It was shown that hospital and general practice experience of urinary tract infections differed widely, with regard both to the age and sex distribution of those suffering from it, and to the causative organisms concerned and their sensitivities to antimicrobial drugs. It is suggested that these differences were so great that conclusions drawn from any study of this subject conducted in one of the two areas cannot be applied to the other, and that those derived from a mixture of the two will vary according to the relative sizes of each of the components.

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“…We have previously reported a high prevalence of coagulase-negative staphylococci in two groups of patients with symptomatic urinary tract infection (Bailey et al, 1971;Dove et al, 1972) but found only a low prevalence of such organisms when screening for asymptomatic bacteriuria in non-pregnant women . In a study of Escherichia coli isolates from schoolgirls (Olling et al, 1973), it was found that the seven 0-serogroups most commonly associated with symptomatic infections were much less frequent in asymptomatic bacteriuria and appeared to be replaced by autoagglutinable strains.…”

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confidence: 90%

Bacteria causing symptomatic urinary tract infection or asymptomatic bacteriuria.

Roberts¹,

Phillips²

1979

J Clin Pathol

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SUMMARY One thousand bacterial isolates from consecutive suprapubic aspirations of urine in two groups of patients with symptomatic urinary tract infection and two groups with asymptomatic bacteriuria were studied.Staphylococci accounted for 13 and 27 % of the isolates from symptomatic patients but for only 3 and 4 % of strains from asymptomatic bacteriuria. Conversely, 18 and 30 % of Escherichia coli isolates from asymptomatic bacteriuria were auto-agglutinable when tested with antisera to the common urinary 0-serogroups, whereas such strains accounted for only 5 and 7 % of the E. coli from symptomatic patients. The high prevalence of auto-agglutinable E. coli in asymptomatic bacteriuria was accompanied by a reduction in the frequency of the common urinary O-serogroups rather than other smooth strains.We have previously reported a high prevalence of coagulase-negative staphylococci in two groups of patients with symptomatic urinary tract infection (Bailey et al., 1971;Dove et al., 1972) but found only a low prevalence of such organisms when screening for asymptomatic bacteriuria in non-pregnant women . In a study of Escherichia coli isolates from schoolgirls (Olling et al., 1973), it was found that the seven 0-serogroups most commonly associated with symptomatic infections were much less frequent in asymptomatic bacteriuria and appeared to be replaced by autoagglutinable strains. More recently , we have presented evidence that, unlike the situation in pregnancy, in the non-pregnant woman symptomatic infections rarely arise from preexisting asymptomatic bacteriuria.These findings raise the question of the relative importance of bacterial and host factors in determining whether or not symptoms occur in the presence of bacteriuria. In this report 1000 isolates, from consecutive suprapubic aspirates of urine, are reviewed with regard to the symptomatic status of the patient. Patients and methodsFour groups of patients were included in the study. Patients attending the urinary infection clinics at

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Diagnosis of Urinary-Tract Infection in General Practice

Cited by 30 publications

References 9 publications

Coagulase-negative staphylococci and micrococci in urinary tract infections.

Coagulase-negative staphylococci and micrococci in urinary tract infections.

The bacteriological examination of urine: a computer-aided study

Bacteria causing symptomatic urinary tract infection or asymptomatic bacteriuria.

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