Diagnosis, pathophysiology and management of chronic migraine: a proposal of the Belgian Headache Society

Paemeleire, Koen; Louis, Paul; Magis, Delphine; Vandenheede, Michel; Versijpt, Jan; Vandersmissen, Bart; Schoenen, Jean

doi:10.1007/s13760-014-0313-z

Cited by 15 publications

(15 citation statements)

References 127 publications

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“…MRI is the imaging modality of choice. However, one study reported normal MR (DWI) brain imaging in a comatose patient with AOP ischemic infarction [ 14 ]. The MRI (DWI) images in Percheron artery infarction can be classified as bilateral paramedian thalamic with rostral midbrain infarction (BPTRMI), bilateral paramedian thalamic without midbrain infarction (BPTWMI), bilateral paramedian and anterior thalamic with midbrain infarction (BPATMI), and bilateral paramedian and anterior thalamic without midbrain infarction [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Artery of Percheron Infarction as an Unusual Cause of Korsakoff’s Syndrome

Zhou

Fox

Anand

et al. 2015

Case Reports in Neurological Medicine

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The Korsakoff syndrome is defined as “an abnormal mental state in which memory and learning are affected out of all proportion to other cognitive functions in an otherwise alert and responsive patient.” Confabulation refers to false or erroneous memories arising, not deliberately, in the context of a neurological amnesia and is often thought of as pathognomonic of the Korsakoff syndrome. Although the exact pathophysiology is unknown, various studies have identified brain lesions in the thalami, mammillary bodies, and frontal cortex. We report a case of a 68-year-old male presenting with acute altered mental status on July 16, 2015. The neuropsychological dysfunctions included prominent Korsakoff's syndrome, which became apparent when the altered mental status resolved. Amnesia was accompanied by prominent confabulation, disorientation, and lack of insight into his own disability. Neuroradiological data indicated that the intralaminar and dorsomedial nuclei in bilateral thalami were infarcted by occlusion of the artery of Percheron. We believe that ours is one of few reported cases of Korsakoff syndrome in a patient with infarction involving the territory of the artery of Percheron. We conclude that bilateral thalamic lesions could cause Korsakoff's syndrome and the intralaminar and dorsomedial nuclei might be important structures in the pathogenesis of confabulation.

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Section: Discussionmentioning

confidence: 99%

Artery of Percheron Infarction as an Unusual Cause of Korsakoff’s Syndrome

Zhou

Fox

Anand

et al. 2015

Case Reports in Neurological Medicine

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“…The etiology and pathogenesis of migraine are still poorly understood [ 4 ]. Epidemiological studies found that there is a genetic and familial predisposition for migraine [ 5 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

Association of genetic loci for migraine susceptibility in the she people of China

Lin

Yao

et al. 2015

J Headache Pain

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Background: The purpose of this study was to investigate the association of the genotype and allele frequencies of the polymorphisms rs4379368, rs10504861, rs10915437, rs12134493 and rs13208321 in She people of China with migraine headache susceptibility. The five alleles were previously identified as being associated with migraine in a Western population, but it was not known if this association would hold in a She population. rs4379368 is in the succinic HMG coenzyme A transferase (C7orf10) gene; rs10504861 is near the matrix metallopeptidase 16 (MMP16) gene; rs10915437 is near the adherens junctions associated protein 1 (AJAP1) gene; rs12134493 is upstream of the tetraspanin 2 (TSPAN2) gene; and rs13208321 is within the four and a half LIM domains protein 5 (FHL5) gene. Methods: This was a case-controlled study conducted in She people of Fujian province in China. Polymerase chain reaction-restriction fragment length polymorphism and direct sequencing were performed. Univariate and multivariate analyses were used to assess the association of the different genotypes of each SNP with migraine.

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“…Algorithms are already starting to be proposed to treat patients suffering from chronic and refractory migraine [90], but their rationale is based on limited data. With a refractory migraine patient, the intervention consists in tertiary prevention: trying to reduce the deficits and functional disabilities deriving from chronic headache and drug overuse; optimizing symptomatic treatment; trying prophylactic treatments and looking for possible therapeutic alternatives.…”

Section: Concentrations and Effects Of Caffeine May Be Increasedmentioning

confidence: 99%

Medication overuse and chronic migraine: a critical review according to clinical pharmacology

Ferrari

Baraldi

Sternieri

2015

Expert Opinion on Drug Metabolism & Toxicology

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In spite of progress in migraine treatment, the prevalence of chronic headaches and MOH has not changed in the course of time. Today, a large number of migraine patients have turned to numerous expert physicians and experienced all sorts of prophylactic treatments without decisive benefits. Their condition seems to have crystallized even more as chronic and intractable. This means that to prevent chronification and MOH, we need more effective drugs and better strategies to use them. In particular, we must detect disease biomarkers and predictive factors for drug response that allow for personalized treatment when migraine is still episodic and make analgesic overuse pointless.

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Diagnosis, pathophysiology and management of chronic migraine: a proposal of the Belgian Headache Society

Cited by 15 publications

References 127 publications

Artery of Percheron Infarction as an Unusual Cause of Korsakoff’s Syndrome

Artery of Percheron Infarction as an Unusual Cause of Korsakoff’s Syndrome

Association of genetic loci for migraine susceptibility in the she people of China

Medication overuse and chronic migraine: a critical review according to clinical pharmacology

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