Diagnosis, treatment and prognosis of otomastoiditis induced by Fusobacterium necrophorum: A retrospective multicentre cohort study

Thevis, Madelon; Leow, Theresa Y.S.; Bekkers, Stijn; Otten, Josje; Waterval, Jérôme J.; Derks, Jolanda; Buil, Jochem B.; Kunst, Dirk; Jansen, Thijs

doi:10.1016/j.anaerobe.2022.102587

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Meningitis is a rare complication. Table 1 provides an overview of all 39 previously published cases of F. necrophorum meningitis in children until the age of 18 years [ 7 – 32 ].…”

Section: Discussionmentioning

confidence: 99%

A Pediatric Case of Fusobacterium necrophorum Mastoiditis and Meningitis Case Report in a Healthy Child and Review of the Literature

Feenstra,

Van Roest,

Boes

et al. 2024

Case Reports in Pediatrics

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In infants and children, bacterial meningitis caused by anaerobic bacteria is rare. However, a serious infection with the anaerobe Fusobacterium necrophorum can occur in previously healthy children with a peak incidence in preschool children and in adolescents. As the clinical presentation can be very similar to meningitis caused by aerobic bacteria, one should consider Fusobacterium necrophorum as the causative agent when preceded by or associated with otitis media with purulent otorrhea or mastoiditis, in combination with minimal or no improvement on empiric antibiotic treatment. As this pathogen can be difficult to culture, anaerobic cultures should be obtained. Prompt treatment with a third‐generation cephalosporin and metronidazole should be initiated once suspected or confirmed. Surgical source control is often necessary, but even with adequate and prompt treatment, the morbidity and mortality in children with a Fusobacterium necrophorum meningitis remains high. In this report, we describe a case of Fusobacterium necrophorum meningitis in a previously healthy child and review the available literature.

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“…Meningitis is a rare complication. Table 1 provides an overview of all 39 previously published cases of F. necrophorum meningitis in children until the age of 18 years [ 7 – 32 ].…”

Section: Discussionmentioning

confidence: 99%

A Pediatric Case of Fusobacterium necrophorum Mastoiditis and Meningitis Case Report in a Healthy Child and Review of the Literature

Feenstra,

Van Roest,

Boes

et al. 2024

Case Reports in Pediatrics

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Skull Base Osteomyelitis

Hamiter

Amorosa

Belden

et al. 2023

Otolaryngologic Clinics of North America

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Management of Otogenic Meningitis: A Proposal for Practical Guidelines from a Multicenter Experience with a Systematic Review

Rubini,

Ronzani,

D’Alessandro

et al. 2024

JCM

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Background: Otogenic meningitis represents the most common and life-threatening complication of infective middle ear diseases. However, no guidelines are available to describe the optimal management strategy and the role of surgical intervention. Methods: A six-year multicenter retrospective study on consecutive patients treated for otogenic meningitis caused by acute otitis and re-exacerbation of chronic otitis at the University Hospital of Verona and Modena was performed, and a systematic review regarding acute otitis media-related meningitis in accordance with the PRISMA 2020 statement was then conducted. Results: From the clinical chart analysis, 16 patients with surgical indications according to our decision-making flow chart were reviewed, with most of them undergoing surgery within 7 days of admission (n = 13, 81%). The systematic review ultimately utilized 24 studies (16 case reports and 8 case series) published between 1990 and 2023, with the overall analysis involving a total of 181 patients. Conclusion: The primary treatment for acute bacterial meningitis relies on antibiotic therapy, with surgical intervention being employed in the event of complications and when the initial treatment is not effective within 48 h. The objective of surgery is to sterilize the tympanic and mastoid cavity, thereby eradicating the suspected infective foci and managing any eventual intracranial complications.

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Diagnosis, treatment and prognosis of otomastoiditis induced by Fusobacterium necrophorum: A retrospective multicentre cohort study

Cited by 3 publications

References 23 publications

A Pediatric Case of Fusobacterium necrophorum Mastoiditis and Meningitis Case Report in a Healthy Child and Review of the Literature

A Pediatric Case of Fusobacterium necrophorum Mastoiditis and Meningitis Case Report in a Healthy Child and Review of the Literature

Skull Base Osteomyelitis

Management of Otogenic Meningitis: A Proposal for Practical Guidelines from a Multicenter Experience with a Systematic Review

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