Diagnosis Value of Colposcope Combined with Serum Squamous Cell Carcinoma Antigen, Carbohydrate Antigen 125, and Carcinoembryonic Antigen for Moderate to Advanced Cervical Cancer Patients Treated with Modified Fuzheng Peiyuan Decoction

Abstract

Objective. To explore the diagnosis value of colposcope combined with serum squamous cell carcinoma antigen (SCC-Ag), carbohydrate antigen 125 (CA125), and carcinoembryonic antigen (CEA) for moderate to advanced cervical cancer patients treated with modified Fuzheng Peiyuan decoction. Methods. The clinical data of 43 moderate to advanced cervical cancer patients treated in Suzhou Hospital of Traditional Chinese Medicine from July 2018 to July 2019 were selected for the retrospective analysis, and 43 healthy women undergoing physical examination in our medical center in the same period were selected as the control group. The cervical cancer patients accepted the modified Fuzheng Peiyuan decoction treatment, the detection of SCC-Ag, CA125, and CEA and colposcope examination were performed to all research subjects, and the changes in indicators such as KPS scores and lesion perfusion parameters in cervical cancer patients before and after treatment were monitored, so as to analysis the clinical diagnosis value of combined diagnosis in treated patients. Results. After treatment, the mean KPS scores were greatly higher and various blood perfusion parameters of lesions and serum SCC-Ag, CA125, and CEA levels were remarkably lower than before ( P value <0.001 for all); the area under the curve of combined test was significantly larger than that of single test, and the sensitivity and specificity of the combined test were the highest; and after medication, the total incidence rate of toxic and side effects was 11.63%. Conclusion. Fuzheng Peiyuan decoction has significant effect in treating moderate to advanced cervical cancer, and colposcope combined with serum test presents more accurate and credible diagnosis results and has great significance for future treatment, which shall be promoted and applied.

Diagnostic Value of SMARCE1 and CRISP3 Combined with Tumor Markers in Cervical Cancer

“…Therefore, the determination of tumor markers presence or content could be used to diagnose the generation of malignant tumors, analyze the patient's condition, monitor metastasis, and judge the prognosis of patients [26]. CEA is an acid glycoprotein isolated from embryonic colon mucosa and colon adenocarcinoma which is expressed on the surface of tissue cell membrane and is widely used in the differential diagnosis of malignant tumors [27]. CA125 is a mucin-like glycoprotein with high molecular weight which can promote cell metastasis and infiltration by influencing mutual recognition and adhesion among cells [28].…”

Spinal epidural metastasis from cervical cancer: Report of two cases and literature review

“…Serum tumor markers play an important role in the monitoring of cervical cancer and are independent prognostic factors. Many studies have confirmed that squamous cell carcinoma antigen (SCC-Ag), cancer antigen 125 (CA125), carcino-embryonic antigen (CEA) play an important role to evaluate prognosis, therapeutic response, local recurrence and distant metastasis in cervical squamous cell carcinoma and adenocacinoma ( Dasari et al, 2015 , Lee et al, 2021 , Zhou et al, 2017 , Huang et al, 2020 , Meng et al, 2021 , Volkova et al, 2021 , Bender et al, 2003 Jul , Kubota et al, 2019 ). For relatively concealed lesions, when no lesions that can explain the symptoms are found in the routine imaging examination and the serum tumor markers increase at the same time, MRI examinationis should be recommended to determine whether there is SEM.…”

Diagnostic Value of SMARCE1 and CRISP3 Combined with Tumor Markers in Cervical Cancer

“…Therefore, the determination of tumor markers presence or content could be used to diagnose the generation of malignant tumors, analyze the patient's condition, monitor metastasis, and judge the prognosis of patients [26]. CEA is an acid glycoprotein isolated from embryonic colon mucosa and colon adenocarci-noma which is expressed on the surface of tissue cell membrane and is widely used in the differential diagnosis of malignant tumors [27]. CA125 is a mucin-like glycoprotein with high molecular weight which can promote cell metastasis and infiltration by influencing mutual recognition and adhesion among cells [28].…”