Diagnostic accuracy and prognostic value of simultaneous hybrid 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging in cardiac sarcoidosis

Abstract

Simultaneous PET/MR is an accurate method for diagnosing CS. FDG-PET and CMR combined offers complementary information on disease pathophysiology. The presence of LGE and FDG uptake on PET/MR identifies patients at higher risk of adverse events. PET and CMR should therefore be considered in the assessment of disease presence, stage, and prognosis in CS.

Myocardial perfusion imaging in cardiac sarcoidosis: A “sine qua non” for prognosis assessment?

“…14 Indeed, in a recent study, concomitant abnormalities in both PET (as expressed by focal FDG uptake) and in MRI (as expressed by late gadolinium enhancement) were the strongest predictive factors for events, even after adjusting for ejection fraction. 15 This finding, obviously, is in accordance with the mismatch pattern of hybrid PET/CT imaging. Unfortunately, as a significant percentage of these patients undergo implantation of defibrillator, sequential imaging with MRI is not always an option.…”

Prevalence of 18F-fluorodeoxyglucose positron emission tomography abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy

“…The relevance of myocardial inflammation to the pathogenesis and clinical phenotype of ARVC is unknown. 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) is an established method for detecting and assessing myocardial inflammation and is used in our centre for the assessment of suspected myocarditis [8]. In this study, we performed a retrospective analysis of patients fulfilling current diagnostic criteria for ARVC who also underwent FDG-PET to test the hypothesis that myocardial inflammation plays a role in disease pathogenesis.…”

“…This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation. [8] William Harvey Research Institute, London, UK; Barts Heart Centre, St Bartholomew's Hospital, London, UK. This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.…”

Genetic Basis of Myocarditis: Myth or Reality?

“…Cardiac involvement is clinically manifest in about 5% of patients with sarcoidosis (sarcoid granulomas can be clinically silent), while it is asymptomatic in about 25% of cases, as confirmed by pathology, i.e., autopsy studies [126,127], and imaging series, either CMR or fluorodeoxyglucose positron emission tomography (PET) [128,129]. Simultaneous PET/MR increases the diagnostic accuracy and offers complementary information on disease pathophysiology [129,130]. Therefore, given that sarcoid granulomas can be clinically silent, the real proportion of cardiac sarcoidosis is likely higher than clinically apparent.…”