Diagnostic Accuracy for Per-Patient Polyp Detection of Second-Generation Capsule Endoscopy Compared to Colonoscopy: A Meta-Analysis of Multicenter Studies

Ali, Hassam; Pamarthy, Rahul; Sarfraz, Shiza; Ali, Eslam

doi:10.7759/cureus.17560

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…Ali et al 54 Sulbaran et al 48 Vuik et al 50 Möllers et al 49 Kjølhede et al 51 Alihosseini et al 53 Spada et al 52 60 There was a significant correlation in the severity (κ = 0.751, p < 0.001) and extent (κ = 0.522, p < 0.001) of UC between the CCE and conventional colonoscopy. In addition, the excellent to good rate of colonic cleanliness in CCE was 80%.…”

Section: Referencesmentioning

confidence: 99%

“…45,47 In the United Kingdom, a national pilot is underway to evaluate CCE as a first-line diagnostic test for patients with a positive FIT test. 12 In recent years many authors [48][49][50][51][52][53][54] systematically reviewed the validity of CCE in clinical practice, specifically its performance in CRC screening.…”

Section: Use Of Cce In Clinical Practice Cce In Crc Screeningmentioning

confidence: 99%

“…References Ali et al 54 Sulbaran et al 48 Vuik et al 50 Möllers et al 49 Kjølhede et al 51 Alihosseini et al 53 Spada et al 52…”

Section: Therapeutic Advances In Gastroenterologymentioning

confidence: 99%

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Clinical utility of colon capsule endoscopy: a moving target?

Jalayeri Nia,

Arasaradnam,

Koulaouzidis

2023

Therap Adv Gastroenterol

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The purpose of this article is to provide an overview of white light colon capsule endoscopy’s current clinical application, concentrating on its most recent developments. Second-generation colon capsule endoscopy (CCE2) is approved by the FDA for use as an adjunctive test in patients with incomplete colonoscopy and within Europe in patients at average risk, those with incomplete colonoscopies or those unwilling to undergo conventional colonoscopies. Since the publication of European Society of GI Endoscopy guidelines on the use of CCE, there has been a significant increase in comparative studies on the diagnostic yield of CCE. This paper discusses CCE2 in further detail. It explains newly developed colon capsule system and the current status on the use of CCE, it also provides a comprehensive summary of systematic reviews on the implementation of CCE in colorectal cancer screening from a methodological perspective. Patients with ulcerative colitis can benefit from CCE2 in terms of assessing mucosal inflammation. As part of this review, performance of CCE2 for assessing disease severity in ulcerative colitis is compared with colonoscopy. Finally, an assessment if CCE can become a cost-effective clinical service overall.

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Section: Referencesmentioning

confidence: 99%

Section: Use Of Cce In Clinical Practice Cce In Crc Screeningmentioning

confidence: 99%

See 1 more Smart Citation

Clinical utility of colon capsule endoscopy: a moving target?

Jalayeri Nia,

Arasaradnam,

Koulaouzidis

2023

Therap Adv Gastroenterol

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“…These studies signaled the markedly improved sensitivity and accuracy of CCE-2 compared to CCE-1. Several subsequent controlled studies have reported the efficacy of CCE-2 in identifying colonic polyps [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ].…”

Section: 2nd-generation Colon Capsule Endoscopy and Polyp Detectionmentioning

confidence: 99%

Colon Capsule Endoscopy in the Diagnosis of Colon Polyps: Who Needs a Colonoscopy?

et al. 2022

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Colon screening programs have reduced colon cancer mortality. Population screening should be minimally invasive, safe, acceptably sensitive, cost-effective, and scalable. The range of screening modalities include guaiac or immunochemical fecal occult blood testing and CT colonography and colonoscopy. A number of carefully controlled studies concur that second-generation capsule endoscopy has excellent sensitivity for polyp detection and a high negative predictive value. Colon capsules fulfill the screening expectation of safety, high sensitivity for polyp detection, and patient acceptance, and appear to straddle the divide between occult blood testing and colonoscopy. While meeting these criteria, there remains the challenges of scaling, capsule practitioner training, resource allocation, and implementing change of practice. Like CT colonography, capsule screening presents the clinician with a decision on the threshold for colonoscopy referral. Overall, colon capsules are an invaluable tool in polyp detection and colon screening and offer a filter that determines “who needs a colonoscopy?”.

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“…However, concerns remain about the use of a procedure considered by many that have yet to be honed to the level of a diagnostic colonoscopy. However, recent studies have shown that CCE has the same diagnostic accuracy as a conventional colonoscopy and tends to outperform CT colonography, especially in detecting small/flat adenomas and sessile serrated lesions [ 2 , 3 , 4 , 5 ]. One barrier to a broader clinical application of CCE is achieving an acceptable completion rate (CR).…”

Section: Introductionmentioning

confidence: 99%

Castor Oil in Bowel Preparation Regimens for Colon Capsule Endoscopy: A Systematic Review with Meta-Analysis

et al. 2022

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Completing colon capsule endoscopy (CCE) investigations rely on successful transit and acceptable bowel preparation quality. We investigated the effect of adding castor oil to the CCE bowel preparation regimen on the completion rate using a meta-analysis of existing literature. We conducted a systematic literature search in PubMed, Web of Science, and Embase. Included studies underwent quality assessment, and data for meta-analysis were extracted. Pooled estimates for excretion rate and acceptable bowel preparation rate were calculated. We identified 72 studies matching our search criteria, and six were included in the meta-analysis. Three of the studies had control groups, although two used historical cohorts. The pooled excretion rate (92%) was significantly higher in patients who received castor oil than in those who did not (73%). No significant difference in acceptable colonic cleanliness was observed. Castor oil has been used in a few studies as a booster for CCE. This meta-analysis shows the potential for this medication to improve excretion rates, and castor oil could be actively considered in conjunction with other emerging laxative regimens in CCE. Still, prospective randomized trials with appropriate control groups should be conducted before any conclusions can be drawn. Prospero ID: CRD42022338939.

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Diagnostic Accuracy for Per-Patient Polyp Detection of Second-Generation Capsule Endoscopy Compared to Colonoscopy: A Meta-Analysis of Multicenter Studies

Abstract: Ali et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cited by 5 publications

References 13 publications

Clinical utility of colon capsule endoscopy: a moving target?

Clinical utility of colon capsule endoscopy: a moving target?

Colon Capsule Endoscopy in the Diagnosis of Colon Polyps: Who Needs a Colonoscopy?

Castor Oil in Bowel Preparation Regimens for Colon Capsule Endoscopy: A Systematic Review with Meta-Analysis

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