Diagnostic Accuracy in Venous Thrombosis

The 125I lAbeled Fibrinogen Test in the Diagnosis of Deep Vein Thrombophlebitis

“…These findings may be associated with edema of the legs, particularly lymph edema, and may also be associated with marked shifts in fluid balance (10). DISCUSSION When the 125I fibrinogen uptake test is used prospectively in patients with no evidence of pre-existing thrombophlebitis, it has been found to agree with phlebography in at least 90% of the cases (6,7,11,12,13,14,15,16). There is an extremely low incidence of false negative results, and this test may be more sensitive than phlebography, since it is capable of identifying small thrombi in veins frequently not accessible to phlebography.…”

Incidence of Pulmonary Embolism

“…On the basis of a number of reports [9][10][11] it has been shown that deep vein thrombosis occurs in some 30°/o of patients undergoing a variety of largely major opera tions, particularly abdominal operations, prostatectomy and hip reconstruction, the frequency varying according to age, the type of operation and the nature of the underly ing condition. Most thrombi are first detect ed within 48 h of operation; almost without exception they first develop in the calf, and the majority remain localized to that region, with only about 10% later spreading proximally to the femoral vein.…”

Incidence of Postoperative Deep Vein Thrombosis in Ophthalmology

“…The clinical diagnosis of postoperative DVT is not very reliable, often the venous thrombosis is missed or clinical signs are absent despite the presence of extensive thrombosis [2,6]. The radioactive fibrinogen technique is used for diagnosing calf and lower thigh venous thrombosis [4] and the doppler ultrasound, for the diagnosis of ileo-femoral and femoro-popliteal venous occlusions [7,8], The two techniques are thus complementary in the diagnosis of postoperative lower limb venous thrombosis.…”