2023
DOI: 10.3390/tropicalmed8020119
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Diagnostic Accuracy of a Thick Blood Smear Compared to qPCR for Malaria Associated with Pregnancy in Colombia

Abstract: This study aimed to evaluate the accuracy of the thick blood smear (TBS) versus quantitative polymerase chain reaction (qPCR) for the diagnosis of malaria associated with pregnancy (MAP) caused by P. falciparum or P. vivax in Colombia in its gestational malaria (GM), placental malaria (PM), and congenital malaria (CM) forms as well as to compare its accuracy in different subgroups of pregnant women according to the presence of fever, anemia and a history of malaria. This was a diagnostic evaluation of 829 preg… Show more

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Cited by 3 publications
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“…Other authors have reported a higher prevalence of clinical manifestations in P. vivax infections, such as headache (81% Vs. 50% in P. falciparum ), fever (73% Vs. 8% in P. falciparum ), musculoskeletal pain (36% Vs. 4% in P. falciparum ), and conjunctival pallor (12% Vs. 0% in P. falciparum ), contrary to the evidence available in PAM that indicates greater damage by P. falciparum [ 11 ]. There are also important differences depending on the diagnostic test, evidencing important limitations of TBS for the diagnosis and epidemiological surveillance of PM and CM [ 12 ]. It has even been documented that in some contexts, the highest proportion of PAM infections are submicroscopic (positive with qPCR and negative with thick blood smear TBS), and they are associated with clinical outcomes [ 11 ] and constitute a great challenge for the elimination of malaria because the majority are asymptomatic [ 13 , 14 ].…”
Section: Introductionmentioning
confidence: 99%
“…Other authors have reported a higher prevalence of clinical manifestations in P. vivax infections, such as headache (81% Vs. 50% in P. falciparum ), fever (73% Vs. 8% in P. falciparum ), musculoskeletal pain (36% Vs. 4% in P. falciparum ), and conjunctival pallor (12% Vs. 0% in P. falciparum ), contrary to the evidence available in PAM that indicates greater damage by P. falciparum [ 11 ]. There are also important differences depending on the diagnostic test, evidencing important limitations of TBS for the diagnosis and epidemiological surveillance of PM and CM [ 12 ]. It has even been documented that in some contexts, the highest proportion of PAM infections are submicroscopic (positive with qPCR and negative with thick blood smear TBS), and they are associated with clinical outcomes [ 11 ] and constitute a great challenge for the elimination of malaria because the majority are asymptomatic [ 13 , 14 ].…”
Section: Introductionmentioning
confidence: 99%