Diagnostic accuracy of anti-gliadin antibodies in Non-Celiac Gluten Sensitivity (NCGS) patients

Infantino, María; Manfredi, Mariangela; Meacci, Francesca; Grossi, Valentina; Severino, Maurizio; Benucci, Maurizio; Bellio, Emanuele; Bellio, Valerio; Nucci, A. Di; Zolfanelli, Federica; Ugolini, S; Catani, S.; Macchia, Donatella

doi:10.1016/j.cca.2015.09.017

Cited by 33 publications

(24 citation statements)

References 39 publications

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“…AGA is considered neither sensitive nor specific for coeliac disease41 while the presence of anti-TTG2 or anti-DGP seropositivity indicates coeliac disease,5 separating from (non-coeliac) gluten sensitivity. In other words, all/most patients with coeliac disease have AGA as well as anti-TTG/DGP seropositivity, and most AGA seropositive patients without anti-TTG/DGP seropositivity are considered (non-coeliac) gluten sensitive 5 41.…”

Section: Discussionmentioning

confidence: 99%

Serum antigliadin antibodies in cerebellar ataxias: a systematic review and meta-analysis

Lin

Wang

Tse

et al. 2018

J Neurol Neurosurg Psychiatry

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Background Gluten sensitivity refers to prominent immunological responses to gluten, usually in conjunction with elevated levels of serum antigliadin antibody (AGA). The association between AGA and cerebellar ataxias has been inconsistently reported. Methods We performed a systematic literature search and a meta-analysis to study the weighted pooled OR of idiopathic cerebellar ataxia (IDCA) cases to controls or to hereditary ataxia (HA) for AGA seropositivity using fixed effect model. Results Eleven studies were included, with a total of 847 IDCA cases, 1654 controls and 445 HA cases. IDCA cases had fourfold higher odds than controls (OR 4.28, 95% CI 3.10 to 5.90) and twofold higher odds than HA cases (OR 2.23, 95% CI 1.45 to 3.44) of having AGA seropositivity. Sensitivity analysis excluding the most weighted study, which accounted for 69% of the total weight, still showed similar associations (IDCA vs controls, OR 3.18, 95% CI 1.79 to 5.67 and IDCA vs HA, OR 1.72, 95% CI 1.03 to 2.86, respectively). The subgroup analysis showed that, when compared with controls, IDCA cases of both East Asian and Western countries had approximately threefold to fourfold higher odds to have AGA seropositivity (OR 3.41, 95% CI 1.67 to 6.97 and OR 4.53, 95% CI 3.16 to 6.49, respectively), suggesting the lack of ethnic heterogeneity. The odds of AGA seropositivity for HA cases was not significantly higher than controls (OR 1.41, 95% CI 0.82 to 2.44). Conclusion Our study indicates the association between AGA and IDCA, across different geographic regions.

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Section: Discussionmentioning

confidence: 99%

Serum antigliadin antibodies in cerebellar ataxias: a systematic review and meta-analysis

Lin

Wang

Tse

et al. 2018

J Neurol Neurosurg Psychiatry

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“…[13,14] In such cases, the innate or adaptive immune response (humoral or cellular) to gluten/wheat results in the presentation of three distinct conditions that are triggered by the ingestion of wheat protein: CD, wheat allergy, and NCGS. [15,16] A possible relationship between NCGS and MD has been previously suggested.…”

Section: Discussionmentioning

confidence: 99%

Gluten Sensitivity Biomarkers in Menière's Disease: Is It a Gluten Related Disorder?

Berardino¹,

Zanetti²,

Socci³

et al. 2017

Preprint

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Abstract:Background: Meniere's disease (MD) has been recently linked to gluten assumption. Approximately 75% of MD patients show positive skin test to food and about 50% of the positive responses are specific to the gliadin acid extract fraction. Aim of this study was to investigate the humoral immune responses to wheat antigens and related autoantigens in MD patients. Methods. We assessed the reactivity of sera from 28 patients with definite MD and 100 healthy controls against a repertoire of 51 antigens usually associated with immune reaction to gluten. Results. MD patients showed an increase of anti-wheat IgA, anti-cerebellar peptide IgA and anti-glutamic acid decarboxylase (GAD) 65 IgM compared to healthy controls. In particular, the increase of antiwheat IgA and GAD 65 IgM has been confirmed in a subgroup of MD patients symptomatically responding to a gluten free diet (GFD). Conclusion. In MD patients, an increase of the antibody production against gluten biomarkers was observed; in particular, anti-wheat IgA seems to be associated to clinical response to GFD.

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“…Infantino e Brusca informam, em seus estudos sobre os anticorpos antigliadina, particularmente os da classe imunoglobulina G (IgG), que este marcador é promissor para o diagnóstico da SNCG/T, tendo sido encontrado em 50% dos pacientes. 98,99 Em um pequeno estudo italiano de 15 crianças diagnosticadas com SNCG/T, evidenciou-se a presença de anticorpos antigliadina IgG (AGA) em 66% dos pacientes. 74 Infantino ressalva, porém, que estes marcadores apresentam inespecificidade nada negligenciável, podendo ocorrer na DC (80-90%), em distúrbios hepáticos autoimunes (21,5%), na doença do tecido conjuntivo (9%), e até mesmo em controles saudáveis (9%).…”

Section: Sensibilidade Não-celíaca Ao Glúten Ou Ao Trigo E Transtornounclassified

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2018

International Journal of Nutrology

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Palavras-chave► sensibilidade não celíaca ao glúten ► sensibilidade ao glúten ► sensibilidade ao trigo ► doenças relacionadas ao glúten ► dieta isenta de glúten ► glúten ► trigo ResumoEntre as reações adversas a alimentos, os distúrbios relacionados ao glúten vêm atualmente ganhando cada vez mais espaço nas publicações científicas e não científicas. Estes distúrbios são divididos em três entidades: doença celíaca (DC), alergia ao trigo (AT) e sensibilidade não-celíaca ao glúten ou ao trigo (SNCG/T), considerando que este cereal vem sendo associado mais frequentemente às manifestações, discutindo-se ainda se não seria o real componente alimentar desencadeante. A DC é uma enteropatia autoimune, enquanto a AT é uma reação de hipersensibilidade, mediada ou não mediada pela imunoglobulina E (IgE). A SNCG/T é uma entidade emergente, de fisiopatologia ainda discutida, que vários pesquisadores propõem como diagnóstico de exclusão em relação à AT e à DC. A SNCG/T vem despertando grande celeuma popular e polêmica nos meios médicos. A presente revisão tem por objetivo abordar a SNCG/T, procurando elencar elementos de distinção dos outros dois distúrbios retrocitados discutindo aspectos como características clínicas, diagnóstico diferencial, fisiopatologia e tratamento. Em muitos trabalhos, salienta-se a possibilidade de sobreposição ou de confusão diagnóstica com outras doenças funcionais gastrointestinais, como síndrome do intestino irritável (SII) e oligossacarídeos, dissacarídeos, monossacarídeos e polióis fermentáveis (FODMAPs, na sigla em inglês). Concluímos que a SNGG/T, embora constitua uma entidade clínica reconhecida por um número expressivo de pesquisadores, ainda é objeto de amplo questionamento quanto à sua caracterização, ao seu diagnóstico e à sua fisiopatologia. Isto posto, considerando sua elevada prevalência estimada e as repercussões populares, indubitavelmente trata-se de assunto digno de estudos mais aprofundados e bem conduzidos. Keywords► non-celiac gluten sensitivity ► sensitivity to gluten ► sensitivity to wheat ► gluten-related diseases ► gluten-free diet ► gluten ► wheat Abstract Among adverse food reactions, gluten-related disorders are now gaining more and more space in scientific and non-scientific publications. These disorders are divided into three entities: celiac disease (CD), wheat allergy (WA), and non-celiac sensitivity to gluten or wheat (NCGS), considering that this cereal is associated more frequently with the manifestations, and since it is also discussed whether or not this grain would be the real triggering food component. Celiac disease is an autoimmune enteropathy, whereas WA is a hypersensitive reaction, mediated or not mediated by immunoglobulin E (IgE). Non-celiac sensitivity to gluten or wheat is an emerging entity of pathophysiology still under discussion, which several researchers propose as a diagnosis of exclusion in relation to CD and WA, and it has aroused great popular excitement and controversy in medical circles. The present review aims to approach NCGS, seeking to di...

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Diagnostic accuracy of anti-gliadin antibodies in Non-Celiac Gluten Sensitivity (NCGS) patients

Cited by 33 publications

References 39 publications

Serum antigliadin antibodies in cerebellar ataxias: a systematic review and meta-analysis

Serum antigliadin antibodies in cerebellar ataxias: a systematic review and meta-analysis

Gluten Sensitivity Biomarkers in Menière's Disease: Is It a Gluten Related Disorder?

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Diagnostic accuracy of anti-gliadin antibodies in Non-Celiac Gluten Sensitivity (NCGS) patients

Cited by 33 publications

References 39 publications

Serum antigliadin antibodies in cerebellar ataxias: a systematic review and meta-analysis

Serum antigliadin antibodies in cerebellar ataxias: a systematic review and meta-analysis

Gluten Sensitivity Biomarkers in Meni&egrave;re's Disease: Is It a Gluten Related Disorder?

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Gluten Sensitivity Biomarkers in Menière's Disease: Is It a Gluten Related Disorder?