Diagnostic accuracy of anti-keratin antibody for rheumatoid arthritis: a meta-analysis

Wang, Xueping; Cheng, Qiansong; Gu, Ming; Leng, Rui‐Xue; Fan, Yin‐Guang; Li, Baozhu; Ye, Dong‐Qing

doi:10.1007/s10067-019-04464-x

Cited by 12 publications

(13 citation statements)

References 42 publications

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“…Previous studies have found that the speci city of AKA in the diagnosis of RA is as high as 79-100%, while the sensitivity is 20-80% [6][7][8]. A meta-analysis of 2350 RA patients and 2067 control subjects showed that AKA had a sensitivity of 0.46 (95% CI 0.44-0.48) and a speci city of 0.94 (95% CI 0.93-0.95) for the diagnosis of RA, the diagnostic odds ratio was 15.86 (95% CI 9.48-26.52), and the area under the curve (AUC) was 0.7194 [9]. APF and AKA antibodies target the same antigen, epithelium laggrin [10].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Risk Factors for Rheumatoid Arthritis in Yunnan: A Small-Scale Case-Control Study

Wen-run

Sun

2022

Computational Intelligence and Neuroscience

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Objective. To study the risk factors of rheumatoid arthritis (RA) in Yunnan and provide reference for its clinical prevention and treatment. Methods. From January 2014 to February 2022, a total of 249 RA patients who were admitted to the First People’s Hospital of Yunnan Province were selected and 149 healthy people were selected as the controls. The medical records, clinical data of blood test results of anticyclic citrullinated polypeptide (anti-CCP) antibody, antikeratin antibody (AKA), and antiperinuclear factor (APF) were collected. Logistic regression and receiver operating curve (ROC) were used to analyze the correlation between blood anti-CCP antibody, AKA, and APF and the occurrence of RA. Results. Univariate analysis showed that the age, proportion of hypertension, and diabetes patients in RA patients were significantly different from those in the control group (p < 0.05), but there was no statistical difference in sex (p > 0.05). The area under the curve (AUC) of the serum anti-CCP antibody level in the diagnosis of RA was 0.76 (95% CI: 0.72–0.81, p < 0.01), the sensitivity was 85.23%, the specificity was 61.45%, and the cutoff value was 18.07AU/mL. The positive rates of AKA (33.73%) and APF (43.37%) in the RA patients were significantly higher than those in the controls (4.03% and 6.04%), and the differences were statistically significant (p < 0.001). After adjusting for age, sex, hypertension, and diabetes, logistic regression analysis showed that anti-CCP positivity, AKA positive, and APF positive were all independent risk factors for RA (OR = 20.24, 95% CI: 9.36–43.77, p < 0.01; OR = 4.33, 95% CI: 1.62–11.60, p < 0.01; OR = 5.28, 95% CI: 2.33–11.99, p < 0.01). Conclusion. Anti-CCP positive, AKA positive, and APF positive are independent risk factors for the occurrence of RA. Serum anti-CCP level has high sensitivity but low specificity in the diagnosis of RA.

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Section: Introductionmentioning

confidence: 99%

Analysis of Risk Factors for Rheumatoid Arthritis in Yunnan: A Small-Scale Case-Control Study

Wen-run

Sun

2022

Computational Intelligence and Neuroscience

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“…Anti-MCV antibodies could also reflect disease activity ( 37 ) and predict radiological damage ( 38 ). Furthermore, AKA had a considerably high specificity for RA diagnosis ( 39 ). In our study, we not only explored the relationship between the proportion of Treg cells and their subsets and DAS28 [non-specific inflammatory indexes (ESR and CRP)] but also analyzed the relationship between Treg cells and RF, ACPA, or AKA status.…”

Section: Discussionmentioning

confidence: 99%

Th1-Like Treg Cells Are Increased But Deficient in Function in Rheumatoid Arthritis

et al. 2022

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ObjectivesThis study aimed to investigate the changes in quantity and function of T helper (Th)-like T regulatory (Treg) cell subsets in peripheral blood (PB) and synovial fluid (SF) of rheumatoid arthritis (RA) patients and to understand their relationship with disease activity.MethodsA total of 86 RA patients and 76 gender and age-matched healthy controls (HC) were enrolled in this study. Th-like Treg frequency and function were determined using flow cytometry. The inhibitory function of Th-like Treg cells was detected using an in vitro co-culture suppression assay.ResultsThe proportion and absolute number of Th1-like Treg cells from RA PB and RA SF were significantly higher than those of HC PB. In RA SF, the proportions of Treg cells and Th1-like Treg cells were significantly lower in the elevated erythrocyte sedimentation rate or the C-Reactive Protein group, and in the positive groups of anti-CCP antibody and anti-MCV antibody. Additionally, the proportions of Treg cells and Th1-like Treg cells from RA SF were negatively correlated with disease activity. However, the expression levels of CD73 and TGF-β1 in Th1-like Treg cells were decreased, and these Treg cells could not effectively inhibit the proliferation of effector T (Teff) cells.ConclusionOur data indicate that Th1-like Treg cells are the predominant Treg cell subset in RA SF, but their suppressive function is defective. Improving the function of Th1-like Treg cells may control inflammation in joints and provide new strategies for Treg-targeted therapies in RA.

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“…However, the composition of TCM is relatively complex, and the underlying mechanisms of TCM in regulating immunogenicity of patients with RA need further experimental verification. In addition, AKA is associated with RA disease activity, which can be used for the early diagnosis ( 29 ). AKA positive patients were more severe than negative patients in terms of joint swelling index, joint tenderness index, rest pain, morning stiffness time, and joint damage.…”

Section: Discussionmentioning

confidence: 99%

Third dose of anti-SARS-CoV-2 inactivated vaccine for patients with RA: Focusing on immunogenicity and effects of RA drugs

et al. 2022

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ObjectivesTo evaluate the immunogenicity of the third dose of inactivated SARS-CoV-2 vaccine in rheumatoid arthritis (RA) patients and explore the effect of RA drugs on vaccine immunogenicity.MethodsWe recruited RA patients (n = 222) and healthy controls (HC, n = 177) who had been injected with a third dose of inactivated SARS-CoV-2 vaccine, and their neutralizing antibody (NAb) titer levels were assessed.ResultsRA patients and HC were age- and gender-matched, and the mean interval between 3rd vaccination and sampling was comparable. The NAb titers were significantly lower in RA patients after the third immunization compared with HC. The positive rate of NAb in HC group was 90.4%, while that in RA patients was 80.18%, and the difference was significant. Furthermore, comparison of NAb titers between RA treatment subgroups and HC showed that the patients in the conventional synthetic (cs) disease-modifying anti-rheumatic drugs (DMARDs) group exhibited no significant change in NAb titers, while in those receiving the treatment of biological DMARDs (bDMARDs), Janus Kinase (JAK) inhibitors, and prednisone, the NAb titers were significantly lower. Spearman correlation analysis revealed that NAb responses to SARS-CoV-2 in HC did differ significantly according to the interval between 3rd vaccination and sampling, but this finding was not observed in RA patients. In addition, NAb titers were not significantly correlated with RA-related laboratory indicators, including RF-IgA, RF-IgG, RF-IgM, anti-CCP antibody; C-RP; ESR; NEUT% and LYMPH%.ConclusionSerum antibody responses to the third dose of vaccine in RA patients were weaker than HC. Our study will help to evaluate the efficacy and safety of booster vaccination in RA patients and provide further guidance for adjusting vaccination strategies.

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Diagnostic accuracy of anti-keratin antibody for rheumatoid arthritis: a meta-analysis

Cited by 12 publications

References 42 publications

Analysis of Risk Factors for Rheumatoid Arthritis in Yunnan: A Small-Scale Case-Control Study

Analysis of Risk Factors for Rheumatoid Arthritis in Yunnan: A Small-Scale Case-Control Study

Th1-Like Treg Cells Are Increased But Deficient in Function in Rheumatoid Arthritis

Third dose of anti-SARS-CoV-2 inactivated vaccine for patients with RA: Focusing on immunogenicity and effects of RA drugs

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