Diagnostic accuracy of brush cytology in canine chronic intranasal disease

Caniatti, M.; Cunha, Nazaré Pinto da; Avallone, Giancarlo; Romussi, S.; Mortellaro, C. M.; Tranquillo, Vito; Ghisleni, Gabriele

doi:10.1111/j.1939-165x.2011.00388.x

Cited by 15 publications

(12 citation statements)

References 31 publications

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“…Nasal lesions may also be sampled using brush cytology. 157 Similarly, when clinical or clinicopathologic patterns are consistent with leishmaniasis, the possible presence of Leishmania should be investigated also in pathologic body fluids such as joint fluids 158,159 , effusions 29 , or cerebrospinal fluid (CSF), although in this latter sample, cellularity is usually so low that PCR may detect the parasite better than cytology. 55 When cutaneous lesions, nodular lesions in other organs, lymph node enlargement, or abnormal accumulation of fluids are absent but the clinical suspicion of leishmaniasis is high, the presence of parasites should be investigated in tissues that contain many cells of the monocyte-macrophage series, such as bone marrow, lymph nodes, or spleen.…”

Section: Samples and Methodsmentioning

confidence: 99%

“…Therefore, any nodular lesion in dogs with clinical or laboratory signs potentially consistent with leishmaniasis (eg, anemia, CKD, alterations of the electrophoretograms, positive serology) should be sampled by fine‐needle aspiration. Nasal lesions may also be sampled using brush cytology . Similarly, when clinical or clinicopathologic patterns are consistent with leishmaniasis, the possible presence of Leishmania should be investigated also in pathologic body fluids such as joint fluids, effusions, or cerebrospinal fluid (CSF), although in this latter sample, cellularity is usually so low that PCR may detect the parasite better than cytology .…”

Section: Tests For Etiological Diagnosis That May Support or Confirm mentioning

confidence: 99%

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Laboratory tests for diagnosing and monitoring canine leishmaniasis

Paltrinieri

Gradoni

Roura

et al. 2016

Veterinary Clinical Pathol

149

232

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Although several reviews on canine leishmaniasis have been published, none thoroughly described clinicopathologic abnormalities and their clinical usefulness. The aim of this review was to provide information concerning current diagnostic tests relevant for clinical pathologists and from a practical perspective. Specifically, in canine leishmaniasis, nonregenerative normocytic normochromic anemia, thrombocytopenia, or leukogram changes may be present. Clinical chemistry and urinalysis may indicate renal dysfunction (azotemia, decreased urine specific gravity, proteinuria) and an inflammatory/immune response (increased acute phase proteins [APP] or α - and/or γ-globulins). Although a potential gammopathy is usually polyclonal, it may also appear oligo- or monoclonal, especially in dogs coinfected by other vector-borne pathogens. When lesions are accessible to fine-needle aspiration (lymphoadenomegaly, nodular lesions, joint swelling), cytology is strongly advised, as the presence of Leishmania amastigotes in a pattern of pyogranulomatous inflammation or lymphoplasmacytic hyperplasia is diagnostic. If the cytologic pattern is inconclusive, the parasite should be identified by histology/immunohistochemistry or PCR on surgical biopsies. Alternatively, cytology and PCR may be performed on bone marrow samples where amastigotes, along with erythroid hypoplasia, myeloid hyperplasia, plasmacytosis, or secondary dysmyelopoiesis can be observed. Dogs with overt leishmaniasis generally have high antibody titers, while low titers predominate in immunologically resistant infected dogs or in exposed dogs with no parasite confirmation. Quantitative serology is recommended in clinically suspect dogs as high-titer antibodies titers may confirm the clinical diagnosis. In confirmed and treated dogs, renal function and inflammatory/immune response variables should be periodically monitored.

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Section: Samples and Methodsmentioning

confidence: 99%

Section: Tests For Etiological Diagnosis That May Support or Confirm mentioning

confidence: 99%

Laboratory tests for diagnosing and monitoring canine leishmaniasis

Paltrinieri

Gradoni

Roura

et al. 2016

Veterinary Clinical Pathol

149

232

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“…Both sampling techniques are typically performed with endoscopic guidance. The diagnostic accuracy of brush cytology was evaluated in dogs with chronic nasal disease in which the gold standard used involved histologic diagnosis and/or clinical follow-up (Caniatti et al, 2012). Similarly, the polypropylene portion of an indwelling catheter with the needle removed or a polypropylene urinary catheter with the end cut at 45° can also be used to obtain tissue specimens.…”

Section: Imprint and Brush Cytologymentioning

confidence: 99%

Respiratory Tract

Burkhard¹

2016

Canine and Feline Cytology

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“…The cytologic diagnosis of nasal neoplasia can be complicated by concurrent inflammation and dysplasia. However, a large, retrospective, canine cytology–histology correlation study demonstrated the utility of cytology in discriminating neoplastic from non‐neoplastic processes in 86% of 138 dogs, with good concordance for the subclassification of tumors as carcinomas (most common), sarcomas, and round cell tumors (least common) …”

Section: Respiratory Tissuesmentioning

confidence: 99%

All lesions great and small, part 2. Diagnostic cytology in veterinary medicine

Sharkey

Seelig

Overmann

2014

Diagnostic Cytopathology

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This is the second in a two-part review of diagnostic cytopathology in veterinary medicine. As in human medicine, cytopathology is a minimally invasive, rapid, and cost-effective diagnostic modality with broad utilization. In this second part, the diagnostic applications of cytology in respiratory, gastrointestinal, genitourinary, endocrine, ocular, and central nervous system tissues are discussed with a section describing fluid analysis in veterinary medicine. As noted in the previous manuscript, which characterized the cytology of the skin/subcutis, musculoskeletal, and lymphoid tissues, the interpretation of veterinary cytology samples must be undertaken with extensive knowledge of the breadth of animal species, including familiarity with the frequency and clinical progression of diseases, both of which can be influenced by species, breed, and husbandry conditions. Similar to part one, this review focuses on the most common domestic companion animal species (dog, cat, and horse) and highlights lesions that are either unique to veterinary species or have relevant correlates in people. The cytologic features and biological behavior of similar lesions are compared, and selected mechanisms of disease and ancillary diagnostics are reviewed when appropriate. Supporting figures illustrate a subset of lesions. While not an exhaustive archive of veterinary cytology, the goal is to give cytopathologists working in human medicine a general impression of correlates and unique entities in veterinary practice.

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Diagnostic accuracy of brush cytology in canine chronic intranasal disease

Abstract: Brush cytology has good diagnostic accuracy for chronic intranasal lesions in dogs.

Cited by 15 publications

References 31 publications

Laboratory tests for diagnosing and monitoring canine leishmaniasis

Laboratory tests for diagnosing and monitoring canine leishmaniasis

Respiratory Tract

All lesions great and small, part 2. Diagnostic cytology in veterinary medicine

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