Diagnostic accuracy of CA125 and HE4 in ovarian carcinoma patients and the effect of confounders on their serum levels

Ahmed, A. A.; Abdou, Ahmed Mahmoud

doi:10.1016/j.currproblcancer.2018.12.004

Cited by 29 publications

(23 citation statements)

References 33 publications

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“…The mean HE4 level in the mothers was 49.7 pmol/L with 95% confidence intervals for the median of 45.6 pmol/L to 57.9 pmol/L. Similar results were presented by other authors [24,25]. The importance of this study lies in the fact that the HE4 levels were measured for the first time in the umbilical cord blood samples.…”

Section: Discussionsupporting

confidence: 87%

Human Epididymis Protein 4 Levels in Neonates with Respiratory Disorder

Surmiak

Szymkowiak

Baumert

2020

BioMed Research International

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Introduction. Transient tachypnea of the newborn (TTN) is one of the most common causes of respiratory distress in the full-term neonates. The diagnosis of TTN in early postnatal period remains problematic for clinicians, and unfortunately, there exist no reliable diagnostic tests for TTN. The elevated human epididymis protein 4 (HE4) levels were observed in the cases of severe bronchitis, pneumonia, and inflammatory processes. However, little is known about the fluctuation of this biomarker concentrations in respiratory disorders in neonatal period. The authors investigated the HE4 levels found in the umbilical cord blood and venous blood samples of the newborns with respiratory disorder (TTN) and blood samples of their mothers. Materials and Methods. The investigated neonates were divided into two groups: 23 neonates with the respiratory insufficiency (transient tachypnea of the newborn, TTN) as the study group and 28 newborns of healthy mothers constituted the control group (CG). The C-reactive protein (CRP) and procalcitonin (PCT) as well as HE4 levels were determined in umbilical cord blood and venous blood for all the examined neonates and their mothers. Results. There were no differences found in the HE4 levels determined for the mothers’ blood samples and umbilical cord blood samples in all investigated groups. In comparison with healthy children, the elevated HE4 levels were observed in neonates with TTN. Significant positive correlation between HE4 and CRP as well as PCT levels was observed in all investigated neonates. The receiver operating characteristic (ROC) curve analysis demonstrated the cut-off value for the serum HE4 in the researched neonates at the level of 318.5 pmol/L, yielding the sensitivity of 73.9% and specificity of 66.7% for the early diagnosis of TTN. Conclusions. Serum HE4 could be considered as a candidate biomarker for the early diagnosis of pulmonary dysfunction in the newborns.

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Section: Discussionsupporting

confidence: 87%

Human Epididymis Protein 4 Levels in Neonates with Respiratory Disorder

Surmiak

Szymkowiak

Baumert

2020

BioMed Research International

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“…The MYH9 gene encodes the heavy chain of non-muscle myosin of class II, isoform A (also called NM IIA). MYH9 plays a different role in human cancers (4–15). MYH9 plays an oncogenic role in a number of types of cancers (5–12), such as gastric cancer, colorectal cancer, esophageal squamous cancer, non-small cell lung cancer and breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Most of EOC is diagnosed at an advanced stage [the International Federation of Gynecology and Obstetrics (FIGO) III or IV stages] because of the lack of specific symptoms and the absence of effective early diagnostic methods, which leads to a poor prognosis (2,3). Recently serum biomarkers such as CA125 and HE4 have been used to monitor the progress and prognosis of the EOC, and also to detect the recurrence of disease after operation or chemotherapy (4,5). However, these biomarkers are neither particularly specific nor extremely sensitive for predicting cancer metastasis, recurrence and prognosis.…”

Section: Introductionmentioning

confidence: 99%

MYH9 overexpression correlates with clinicopathological parameters and poor prognosis of epithelial ovarian cancer

Liu

Deng

et al. 2019

Oncol Lett

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The aim of the present study was to investigate the expression of myosin 9 (MYH9) in epithelial ovarian cancer and to explore its correlation with the clinicopathological parameters and prognosis of epithelial ovarian cancer (EOC). A total of 265 cases of paraffin-embedded ovarian cancer tissues and 41 paratumor tissues which had been pathologically confirmed at the Memorial Hospital of Sun Yat-sen University from 2009 to 2017 were included in the present study. MYH9 expression was investigated with immunohistochemistry using a polyclonal antibody specific for MYH9. MYH9 expression is associated with disease progression free and overall survival in epithelial ovarian cancer patients; and the expression of MYH9 is associated with International Federation of Gynecology and Obstetrics stage, lymph node metastasis, intraperitoneal metastasis, survival status (at last follow-up), intraperitoneal recurrence, residual tumor size and ascites with tumor cells. Moreover, in a multivariate model MYH9 overexpression was an independent predictor of poor survival in epithelial ovarian cancer. MYH9 may be a candidate that plays a oncogenic role in epithelial ovarian cancer. MYH9 is a useful independent prognostic marker in epithelial ovarian cancer, and it may provide a candidate target therapy treatment of ovarian cancer in the future.

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“…The ideal preoperative prediction model should accurately identify the optimal and suboptimal surgical outcome, have wide applicability, be accurate and be noninvasive. CA125 and HE4 are considered to be the most promising serum markers of ovarian cancer [12][13][14][15][16][17]. The purpose of our study was to explore whether the combination of preoperative serum CA125 level and preoperative serum HE4 level could establish a reliable noninvasive preoperative predictive score to assess resectability in initial treatment of advanced ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Preoperative serum levels of HE4 and CA125 predict primary optimal cytoreduction in advanced epithelial ovarian cancer: a preliminary model study

Feng

Liao

2020

J Ovarian Res

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Objective: The aim of this study is to establish a noninvasive preoperative model for predicting primary optimal cytoreduction in advanced epithelial ovarian cancer by HE4 and CA125 combined with clinicopathological parameters. Methods: Clinical data including preoperative serum HE4 and CA125 level of 83 patients with advanced epithelial ovarian cancer were collected. The sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy of each clinical parameter were calculated. The Predictive Index score model and the logistic model were constructed to predict the primary optimal cytoreduction. Results: Optimal surgical cytoreduction was achieved in 62.65% (52/83) patients. Cutoff values of preoperative serum HE4 and CA125 were 777.10 pmol/L and 313.60 U/ml. (1) Patients with PIV ≥ 6 may not be able to achieve optimal surgical cytoreduction. The diagnostic accuracy, NPV, PPV and specificity for diagnosing suboptimal cytoreduction were 71, 100, 68, and 100%, respectively. (2) The logistic model was: logit p = 0.12 age − 2.38 preoperative serum CA125 level − 1.86 preoperative serum HE4 level-2.74 histological type-3.37. AUC of the logistic model in the validation group was 0.71(95%CI 0.54-0.88, P = 0.025). Sensitivity and specificity were 1.00 and 0.44, respectively. Conclusion: Age, preoperative serum CA125 level and preoperative serum HE4 level are important non-invasive predictors of primary optimal surgical cytoreduction in advanced epithelial ovarian cancer. Our PIV and logistic model can be used for assessment before expensive and complex predictive methods including laparoscopy and diagnostic imaging. Further future clinical validation is needed.

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Diagnostic accuracy of CA125 and HE4 in ovarian carcinoma patients and the effect of confounders on their serum levels

Cited by 29 publications

References 33 publications

Human Epididymis Protein 4 Levels in Neonates with Respiratory Disorder

Human Epididymis Protein 4 Levels in Neonates with Respiratory Disorder

MYH9 overexpression correlates with clinicopathological parameters and poor prognosis of epithelial ovarian cancer

Preoperative serum levels of HE4 and CA125 predict primary optimal cytoreduction in advanced epithelial ovarian cancer: a preliminary model study

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