Diagnostic Accuracy of Capsule Endoscopy for Small Bowel Crohn's Disease Is Superior to That of MR Enterography or CT Enterography

Jensen, Michael D.; Nathan, Torben; Rafaelsen, Søren Rafael; Kjeldsen, Jens

doi:10.1016/j.cgh.2010.10.019

Cited by 231 publications

(173 citation statements)

References 21 publications

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“…This is why early and accurate diagnosis of SB-CD is important. CE is a useful and extended tool in this setting, and has shown to be superior to other diagnostic modalities (17,18).…”

Section: Discussionmentioning

confidence: 99%

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Valenzuela¹,

López²,

Fernández³

et al. 2016

Rev Esp Enferm Dig

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Background and aims:Capsule endoscopy is an extended tool for the diagnosis of small bowel Crohn's disease. However, factors associated with positive findings of this technique have not been well established. Our aim is to asses which factors are associated with a better diagnostic yield of capsule endoscopy in suspected small bowel Crohn's disease.Material and methods: This was a retrospective study including patients under capsule endoscopy because of suspected small bowel Crohn's disease. Demographic data of these patients, as well as symptoms and laboratory data including hemoglobin levels, count of leucocytes and platelets, and levels of C-reactive protein, erythrocyte sedimentation rate and fecal calprotectin were collected. Capsule endoscopy studies were classified as negative (no lesions) or positive (lesions suggestive of Crohn's disease). Descriptive, univariate and multivariate analysis were done, as well as diagnostic yield tests of the different markers for predicting lesions in capsule studies.Results: One hundred and twenty-four patients were included (85 women and 39 men). The average age was 38.21 years. Levels of C-reactive protein and fecal calprotectin were the markers more frequently associated with positive findings in capsule endoscopy. Calprotectin presented the best sensitivity as isolated marker. The association of altered levels of C-reactive protein and calprotectin showed the best specificity and predictive values.Conclusions: C-reactive protein and fecal calprotectin are appropriate biomarkers for selecting patients with suspected Crohn's disease of the small bowel for capsule endoscopy studies.

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“…This is why early and accurate diagnosis of SB-CD is important. CE is a useful and extended tool in this setting, and has shown to be superior to other diagnostic modalities (17,18).…”

Section: Discussionmentioning

confidence: 99%

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Valenzuela¹,

López²,

Fernández³

et al. 2016

Rev Esp Enferm Dig

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“…Thereby, oral contrast application (enterography) provides similar quality of the images but improves patient comfort [14][15][16]. Inflammatory alterations of the small bowel and extraluminal complications such as abscess or fistula are equally well visualized.…”

Section: Radiology In Imaging Small Bowel Crohn's Diseasementioning

confidence: 90%

Detecting and Managing Small Bowel Crohn’s Disease – Capsule Endoscopy Becoming a First Line Diagnostic Method?

Hausmann¹,

Albert²

2011

J Gastrointest Dig Syst

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Small bowel endoscopy is crucial for diagnosing small bowel Crohn's disease, and capsule endoscopy is complemented by balloon-assisted enteroscopy to take biopsies and by magnetic resonance imaging to visualize enteral and extra-intestinal involvement. Recently, imaging has also become a key instrument to manage Crohn's disease patients. Treatment control is advised for patients who have undergone bowel resections and is increasingly used to testify treatment success in non-operated patients, too. In this review we present the modern imaging methods to diagnose and to manage Crohn's disease with a special focus on the small bowel. Moreover, current knowledge on the impact of diagnostic methods on the patients' outcome is reported.

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“…42 SBCE has a high sensitivity for lesions consistent with small bowel CD, including mild lesions and those located in the proximal small bowel. [43][44][45] In patients with suspected CD, it is possible to confidently exclude the diagnosis when no lesions are identified by SBCE 46 . However, the lesions which are typical of active small bowel CD, such as villous oedema or aphthous ulcerations (Fig.…”

Section: Crohn's Diseasementioning

confidence: 99%

Current Clinical Indications for Small Bowel Capsule Endoscopy

Rosa

Cotter

2015

Acta Med Port

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RESUMOIntrodução: A enteroscopia por cápsula é o exame de primeira linha no diagnóstico de diversas patologias do intestino delgado. Este artigo tem por objectivo rever e analisar criticamente as indicações actuais para enteroscopia por cápsula na prática clínica. Material e Métodos: Revisão bibliográfica suportada em artigos indexados na PubMed. Resultados e Discussão: A enteroscopia por cápsula permite a avaliação não invasiva da mucosa do intestino delgado, com elevado rendimento diagnóstico. Em doentes com hemorragia digestiva de causa obscura, o rendimento da enteroscopia por cápsula aumenta quando realizada precocemente após o evento hemorrágico. O tratamento das angiectasias com enteroscopia assistida por balão permite diminuir a recidiva hemorrágica, enquanto o risco de recidiva em doentes com enteroscopia por cápsula "negativa" é controverso. A entero-TC/entero-RM podem superiorizar-se à enteroscopia por cápsula no diagnóstico de alguns tumores. O 'Smooth Protruding Index on Capsule Endoscopy' (score SPICE) auxilia na diferenciação entre verdadeiros tumores submucosos e abaulamentos não patológicos. A enteroscopia por cápsula é valiosa em doentes com suspeita de doença de Crohn quando a ileocolonoscopia não é diagnóstica, permitindo também estadiar a extensão e actividade das lesões em doentes com diagnóstico prévio de doença de Crohn, com potenciais implicações prognósticas e terapêuticas. A enteroscopia por cápsula permite ainda o diagnóstico de complicações em doentes com doença celíaca refractária. Conclusões: Actualmente, a importância da enteroscopia por cápsula é reconhecida no contexto da hemorragia digestiva de causa obscura e/ou suspeita de tumores do intestino delgado, bem como na suspeita de doença de Crohn ou em doentes com doença de Crohn conhecida para determinar a localização, extensão e actividade da doença, e ainda para a investigação de doentes com doença celíaca refractária. Palavras-chave: Doenças Intestinais; Endoscopia por Cápsula. ABSTRACT Introduction:Small bowel capsule endoscopy is currently the first line diagnostic examination for many diseases affecting the small bowel. This article aims to review and critically address the current indications of small bowel capsule endoscopy in clinical practice. Material and Methods: Bibliographic review of relevant and recent papers indexed in PubMed.

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Diagnostic Accuracy of Capsule Endoscopy for Small Bowel Crohn's Disease Is Superior to That of MR Enterography or CT Enterography

Cited by 231 publications

References 21 publications

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Detecting and Managing Small Bowel Crohn’s Disease – Capsule Endoscopy Becoming a First Line Diagnostic Method?

Current Clinical Indications for Small Bowel Capsule Endoscopy

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Diagnostic Accuracy of Capsule Endoscopy for Small Bowel Crohn's Disease Is Superior to That of MR Enterography or CT Enterography

Cited by 231 publications

References 21 publications

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Detecting and Managing Small Bowel Crohn’s Disease – Capsule Endoscopy Becoming a First Line Diagnostic Method?

Current Clinical Indications for Small Bowel Capsule Endoscopy

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Product

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Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease