Diagnostic accuracy of different blood cells-derived indexes in rheumatoid arthritis

Abstract

To evaluate the performance of different blood cells-derived indexes in the diagnosis of rheumatoid arthritis (RA). Neutrophil-to-lymphocyte ratio (NLR), lymphocyte to monocyte ratio, platelet to lymphocyte ratio (PLR), systemic inflammation response index (SIRI), and aggregate inflammation systemic index were calculated in 199 consecutive RA patients and 283 sex and age-matched controls (147 healthy donors and 136 patients with other rheumatic diseases). Area under the curve (AUCs), sensitivity and specificity were calculated to evaluate the accuracy of indexes in discriminating between RA and controls. Association between indexes and RA variables was explored by multiple linear regression analyses. Blood cells-derived indexes did not demonstrate good accuracy in differentiating RA from controls with lymphocyte to monocyte ratio, the index with the best diagnostic performance, having 63.6% of sensitivity and 65.3% specificity [AUC (95%CI) = 0.67 (0.62–0.72]. The accuracy of the indexes in differentiating RA from healthy donors was significantly higher than that (AUCs < 0.6 for all comparisons) differentiating RA from rheumatic diseases. In RA, SIRI and aggregate inflammation systemic index showed significant association with C-reactive protein and erythrocyte sedimentation rate. Our results do not support the use of blood cells-derived indexes for the diagnosis of RA, suggesting that they might reflect chronic inflammatory burden in rheumatic diseases rather than, specifically, in RA.

Diagnostic Value of Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte, and Monocyte-to-Lymphocyte Ratios for the Assessment of Rheumatoid Arthritis in Patients with Undifferentiated Inflammatory Arthritis

“…To the best of our knowledge, this is the first study to evaluate the diagnostic accuracy of NLR, PLR, and MLR in distinguishing RA from non-RA in patients with UIA. The diagnostic value of these hematologic markers in RA has also been reported previously, but all previous studies investigating this topic focused on the diagnostic role of NLR, PLR, and MLR in discriminating RA between healthy subjects rather than discriminating RA between non-RA in UIA patients [ 23 , 24 , 25 , 26 ]. Because clinicians usually encounter patients with joint symptoms rather than healthy, asymptomatic individuals, we believe that our study better reflects the actual clinical situation.…”

“…Because clinicians usually encounter patients with joint symptoms rather than healthy, asymptomatic individuals, we believe that our study better reflects the actual clinical situation. In discriminating RA from healthy subjects, the AUC of NLR, PLR, and MLR varied considerably in previous studies, ranging from less than 0.55 to 0.831 [ 23 , 24 , 25 , 26 ]. In our study, the AUC value of MLR was 0.701 for detecting RA in patients with UIA.…”

Predictive ability of inflammatory markers and laboratory parameters in Legg-Calvé-Perthes disease

“…mune diseases, metabolic syndrome, ischemic diseases, and malignancies, has been recently recognized and utilized as an independent predictor of their outcomes. [6][7][8][9] In the present study, we aimed to examine the clinical availability of the NLR and SII as well as common laboratory parameters for the prediction of the prognosis in LCPD patients undergoing surgical containment therapy in the active stage of the disease.…”

Kombine hematolojik inflamatuar indekslerin akut pankreatit hastalarında kötü sonlanımı öngörmedeki rolü

“…[1][2][3] Lymphocyte, neutrophil, and thrombocyte counts can be effective in the inflammation process as well as with the proportional indices between them, and they are also the subject of studies on many chronic inflammatory diseases since they are associated with the prognosis. [4,5] The neutrophil to lymphocyte ratio (NLR) was studied in relation to asthma, [7] chronic obstructive pulmonary disease (COPD), [8] and intensive care patients. [9] The neutrophil to lymphocyte ratio (NLR), neutrophil/lymphocyte*platelet ratio (NLPR), systemic inflammation response index (SIRI), and aggregate inflammation systemic index (AISI) were examined in patients diagnosed with thyroiditis, [4] rheumatoid arthritis, [5] and pulmonary fibrosis [6] in order to examine the post-operative inflammatory processes [10] even in patients diagnosed with COVID-19.…”