Diagnostic accuracy of dual-energy CT virtual non-calcium images with different related contrast material values for the detection of bone marrow edema in knee

Liang, Jianchao; Fang, Yijie; Jiang, Yunping; Zhan, Yingying; Hong, Guobin

doi:10.1016/j.ejrad.2020.109385

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…Additional research [25,26] indicated that DECT showed relatively high sensitivity (88.6%) and specificity (100%) in the diagnosis of osteoporotic vertebral compression fractures. It also demonstrated 81.8% sensitivity and 94.6% specificity in detecting subtle fractures and bone marrow edema in knee joints.…”

Section: Discussionmentioning

confidence: 99%

Quantitative measurements of dual-energy CT parameters in the diagnosis of osteoporosis – a highly sensitive and specific technique: An observational study

Chen,

Guo,

Zhao

et al. 2024

Medicine

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With the aging of the population in our society, osteoporosis (OP) has become one of the chronic diseases that seriously threaten the physical health of the elderly, leading to a heavy burden on healthcare. In recent years, with the continuous development of dual-energy CT (DECT) technology, quantitative measurements of DECT parameters, which is highly sensitive to OP, provides accurate results, is convenient and cost-effective, and is expected to be widely used in bone density testing. This study was aimed to explore the value of quantitative measurements of DECT parameters in diagnosing OP, in order to better guide clinical judgments and treatment. A total of 187 patients who underwent dual-energy X-ray and DECT examinations at Tianjin hospital between January 2022 and June 2023 were included as participants in this study. The bone mineral density (BMD) values of the lumbar spine (L1–L4) were determined using dual-energy X-ray absorptiometry. Simultaneously, CT scans of the lumbar spine (L1–L4) were conducted to measure the CT values of contrast media (CM), mixed-energy image CT values (regular CT value [rCT]), calcium concentration (CaD), as well as fat fraction (FF). Pearson correlation analysis was used to examine the relationship between the quantitative measurements of L1 to L4 vertebral bodies obtained from DECT and BMD. The values of CM, rCT, and CaD in the OP group were all lower than those in the non-OP group with statistical significance (P < .001). Conversely, the fat fraction parameter value in the OP group was significantly higher in contrast with the non-OP group (P = .004); there was a positive correlation between CM, rCT, CaD, and BMD values (R = 0.579, P < .001; R = 0.604, P < .001; R = 0.563, P < .001); CM, rCT, and CaD had high diagnostic value for OP, as evidenced by AUCs of 0.935 (95% CI: 0.900–0.971), 0.956 (95% CI: 0.925–0.987), and 0.926 (95% CI: 0.858–0.954), respectively, all with P values < .001. Quantitative measurement of DECT parameters showed a high sensitivity as well as a high specificity in the diagnosis of OP. It is also highly feasible and holds significant clinical diagnostic value, making it a suitable candidate for widespread application.

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Section: Discussionmentioning

confidence: 99%

Quantitative measurements of dual-energy CT parameters in the diagnosis of osteoporosis – a highly sensitive and specific technique: An observational study

Chen,

Guo,

Zhao

et al. 2024

Medicine

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“…In addition, single-source consecutive DECT showed lower specificity compared with the dual source CT; moreover, fast kilovoltage switching techniques showed similar estimates of diagnostic accuracy as a dual source technique compared with dual-layer DECT [ 3 ]. Different studies used different Rel.CM values for diagnosing TBMLs [ 5 , 6 , 8 , 39 , 40 ]; their results showed that the VNCa image with a Rel.CM value of 1.45 could be an optimal parameter. Therefore, for the evaluation of TBML on DECT in the clinical, we should try to read the images by certified experienced readers instead of trainees.…”

Section: Dectmentioning

confidence: 99%

Traumatic bone marrow lesions in dual-energy computed tomography

et al. 2022

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Traumatic bone marrow lesions (TBMLs) are considered to represent a range of concealed bone injuries, including haemorrhage, infarction, and localised oedema caused by trabecular microfracture occurring in the cancellous bone. If TBMLs are not managed timeously, they potentially cause a series of complications that can lead to irreversible morbidity and prolonged recovery time. This article reviews interesting image findings of bone marrow lesions in dual-energy computed tomography (DECT). In addition to combining the benefits of traditional CT imaging, DECT also reveals and identifies various structures using diverse attenuation characteristics of different radiographic spectra. Therefore, DECT has the capacity to detect TBMLs, which have traditionally been diagnosed using MRI. Through evaluating DECT virtual non-calcium maps, the detection of TBMLs is rendered easier and more efficient in some acute accidents.

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“…A total of 237 articles were identi ed by searching databases and removing duplicates. After initial screening of titles and abstracts, 64 articles were further assessed by scrutinizing the full texts against the predesigned criteria, and 9 articles [11][12][13][14][15][16][17][18][19] were eventually included in analysis.…”

Section: Literature Searchmentioning

confidence: 99%

Diagnostic Accuracy of Dual-energy CT for Bone Marrow Edema in Patients with Acute Knee Injuries: A Systematic Review and Meta-analysis

Chen

Fang

et al. 2021

Preprint

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Background: The prevalence of knee injury is high and early diagnosis is significant to guide clinical treatment. MRI is recognized as the gold standard for detecting bone marrow edema (BME) in patients with acute knee injury, but limitations still exist. Dual-energy CT (DECT) is investigated as a promising alternative.Methods: We systematically retrieved studies from EMBASE, Scopus, PUBMED, and the Cochrane Library and collected gray literatures. According to PRISMA-DTA guidelines, a systematic review was performed from inception to July 31, 2021, assessing the diagnostic accuracy of DECT for detecting BME in at least 10 adult patients with acute knee injuries and with an MRI reference standard. Study details were independently extracted by two reviewers. Meta-analysis was performed using a bivariate mixed-effects regression model with subgroup analysis performed to evaluate for sources of variability. Results: Nine studies evaluating 290 patients between the ages of 23–53 with acute knee injuries undergoing DECT and MRI were included in analysis. Summary sensitivity, specificity, and AUC values for BME were 85% (95% confidence interval (CI) 77–90%), 96% (95% CI 93–97%), and 0.97 (95% CI 0.95–0.98), respectively. There were no statistically significant differences in specificity and sensitivity amongst comparative subgroups to account for presumed variability amongst studies.Conclusion: DECT is accurate for detecting BME in patients with acute knee injuries and can be used as an alternative to MRI, particularly when MRI is contraindicated or unavailable.

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Diagnostic accuracy of dual-energy CT virtual non-calcium images with different related contrast material values for the detection of bone marrow edema in knee

Cited by 7 publications

References 15 publications

Quantitative measurements of dual-energy CT parameters in the diagnosis of osteoporosis – a highly sensitive and specific technique: An observational study

Quantitative measurements of dual-energy CT parameters in the diagnosis of osteoporosis – a highly sensitive and specific technique: An observational study

Traumatic bone marrow lesions in dual-energy computed tomography

Diagnostic Accuracy of Dual-energy CT for Bone Marrow Edema in Patients with Acute Knee Injuries: A Systematic Review and Meta-analysis

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