Diagnostic accuracy of gastroesophageal reflux disease questionnaire for gastroesophageal reflux disease: A systematic review and meta‐analysis

Abstract

BackgroundThe use of a symptom‐based gastroesophageal reflux disease (GERD) questionnaire (GerdQ) for GERD diagnosis has gained interest due to its greater efficacy and ease of use than other available questionnaires. However, different guidelines have given inconsistent recommendations regarding using GerdQ as a diagnostic test. This meta‐analysis summarized the diagnostic accuracy of GerdQ for diagnosing GERD.MethodsStudies published up to April 12, 2023, and indexed in MEDLINE, EMBASE, SCOPUS, Web of Science, and the Cochrane Library were searched. Diagnostic test accuracy studies comparing GerdQ with upper endoscopy and/or pH‐metry for GERD diagnosis in adult patients with symptoms suggestive of GERD were included. The study quality was assessed using the QUADAS‐2 tool. Meta‐analysis using bivariate (Reitsma) analysis was done to summarize the overall sensitivity, specificity, likelihood ratios (LRs), and diagnostic odds ratio (DOR). The summary receiver operating characteristics (SROC) curve was visualized, and the area under the ROC (AUC) was calculated.Key ResultsA total of 13 studies with 11,166 participants were included in the meta‐analysis. The pooled sensitivity, specificity, positive LR, negative LR, and DOR for GerdQ (cut‐off value of ≥8) were 66.9% (95% CI 56.4%–73.1%), 65.2% (95% CI 56.4%–73.1%), 1.93 (95% CI 1.55–2.42), 0.51 (95% CI 0.38–0.66), and 3.89 (95% CI 2.44–5.89), respectively. The overall AUC from the SROC was 0.705. The subgroup analysis showed similar pooled sensitivity, specificity, and DOR between Asian and non‐Asian studies.Conclusions & InferencesGerdQ had moderate sensitivity and specificity for GERD diagnosis. GerdQ can still be recommended as a diagnostic tool for GERD, especially when the PPI test is unavailable or contraindicated.

The prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux in patients with dysphagia after radiotherapy for nasopharyngeal carcinoma

“…The objectives of this study were to determine (i) the prevalence of GERD and LPR in patients with NPC, and attempt to correlate it with dysphagia, aspiration, and aspiration pneumonia; (ii) the risk factors that have a significant association with GERD and LPR after treatment for NPC; and (iii) the validity of applying a gastroesophageal reflux disease questionnaire (GERDQ) 34 and reflux symptom index (RSI), 35 two common questionnaires, to screen and evaluate for the presence and severity of GERD and LPR, respectively, in post‐irradiated patients with NPC. We hypothesized that there would be a higher prevalence of GERD and LPR after radiotherapy in patients with NPC, which is associated with dysphagia, aspiration, and aspiration pneumonia, than in a control group of non‐irradiated patients.…”