Diagnostic Accuracy of Global Registry of Acute Coronary Events (GRACE) Risk Score in ST-Elevation Myocardial Infarction for In-Hospital and 360-Day Mortality in Japanese Patients

Fujii, Toshiharu; Suzuki, Toshihiko; Torii, Sho; Murakami, Tsutomu; Nakazawa, Gaku; Masuda, Naoki; Shinozaki, Norihiko; Matsukage, Takashi; Ogata, Nobuhiko; Yoshimachi, Fuminobu; Ikari, Yuji

doi:10.1253/circj.cj-14-0808

Cited by 38 publications

(34 citation statements)

References 19 publications

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“…Although several systems have been used for risk stratification in the patients with STEMI, such as TIMI and GRACE, the sophisticated calculation usually makes them inconvenient to operate at bedside in daily clinical practice [9,10]. Our results suggest that MSI of 1.4 or greater could be used for risk stratification in the patients with STEMI, although a large, more sufficient study is required to demonstrate these findings in the future.…”

Section: Clinical Implicationmentioning

confidence: 72%

“…Risk assessment provides an opportunity to integrate various patient characteristics into a semiquantitative score that can convey an overall estimate of a patient's prognosis; can dictate the acuity, intensity, and location of care; and can provide the patient and family with a more informed sense of potential outcome [8]. At present, several systems of risk stratification such as Thrombolysis In Myocardial Infarction (TIMI) and Globle Register Acute Coronary Events (GRACE) are used, but the sophisticated calculation usually makes them inconvenient to operate at bedside in daily clinical practice [9,10]. Recently, Huang et al [11] suggested that admission SI of 0.7 or greater is a useful predictor for short-term outcomes in the patients with STEMI.…”

Section: Introductionmentioning

confidence: 99%

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Modified Shock Index is a Predictor for 7-Day Outcomes in Patients With STEMI

Shangguan

et al. 2015

The American Journal of Emergency Medicine

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Section: Clinical Implicationmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Modified Shock Index is a Predictor for 7-Day Outcomes in Patients With STEMI

Shangguan

et al. 2015

The American Journal of Emergency Medicine

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“…(1-Sensitivity) 2 +(1-Sensitivity) 2 The incremental additive information of the shock index over Killip-class for the prediction of MACE was assessed with c-statistics, as previously described. 25 All statistical tests were 2-tailed, and a P-value <0.05 was considered statistically significant.…”

Section: Study Populationmentioning

confidence: 99%

Shock Index as a Predictor of Myocardial Damage and Clinical Outcome in ST-Elevation Myocardial Infarction

Reinstadler

Fuernau

Eitel

et al. 2016

Circ J

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Background: Data on the prognostic value of the shock index in patients with ST-elevation myocardial infarction (STEMI) are scarce. Furthermore, the relationship of the shock index with myocardial damage is unknown. The aim of this study was to evaluate the association of the shock index with markers of myocardial damage and clinical outcome in patients with STEMI. Methods and Results:This multicenter study analyzed 791 patients. Patients were categorized in 2 groups according to the admission shock index (optimized cut-off=0.62). Infarct severity was determined by cardiac magnetic resonance (CMR) imaging. Patients with cardiogenic shock that were unable to undergo CMR acquisition were excluded. Major adverse cardiac events (MACE) were defined as a composite of death, reinfarction and congestive heart failure within 12 months. Patients with elevated admission shock index (n=321 [40.6%]) had a significantly larger area-at-risk (37. Conclusions: STEMI patients with an elevated admission shock index had more pronounced myocardial and microvascular damage. Moreover, the shock index was independently associated with MACE at 12 months. (Circ J 2016; 80: 924 -930)

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“…the platelet-to-lymphocyte ratio (PLR), has acted as an available biomarker in predicting the risk of future CV in patients with CVD [9]. An already well-validated predictor of CVD events for ACS patients is the Global Registry of Acute Coronary Events (GRACE) risk score [10,11]. However, so far, no research has been reported that explores the relationship between PLR and GRACE risk score.…”

Section: Introductionmentioning

confidence: 99%

Platelet-to-Lymphocyte Ratio Improves the Predictive Power of GRACE Risk Score for Long-Term Cardiovascular Events in Patients with Acute Coronary Syndrome

Zhou

Fan²,

Wan³

et al. 2016

Cardiology

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Objectives: This study aims to evaluate the relationship between platelet-to-lymphocyte ratio (PLR) and GRACE risk score and to examine whether PLR on admission can improve the predictive value of GRACE risk score for cardiovascular disease (CVD) events in patients with acute coronary syndrome (ACS). Methods: PLR was calculated from the platelet and lymphocyte counts from the complete blood count of 2,230 ACS patients upon admission. The GRACE risk score was also calculated. Results: Spearman's rank correlation demonstrated that GRACE risk score was positively correlated with PLR (r = 0.190, p < 0.001). After a median follow-up period of 58 months, multivariate Cox analysis showed that both GRACE risk score [hazard ratio (HR) 1.092, 95% confidence interval (CI) 1.067-1.117, p < 0.001] and PLR (HR 1.100, 95% CI 1.088-1.112, p < 0.001) could independently predict CVD events. Receiver-operating characteristic curve (ROC) analysis proved that using PLR together with GRACE risk score improved the score from 0.70 (95% CI 0.67-0.73, p < 0.001) when used alone to 0.81 (95% CI 0.79-0.83, p < 0.001) for CVD events and from 0.73 (95% CI 0.70-0.77, p < 0.001) when used alone to 0.80 (95% CI 0.77-0.83, p < 0.001) for all-cause mortality. Conclusions: This study proves, for the first time, a positive association between GRACE risk score and PLR, and that a combination of PLR and GRACE risk score is more effective in predicting CVD events in ACS patients.

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Diagnostic Accuracy of Global Registry of Acute Coronary Events (GRACE) Risk Score in ST-Elevation Myocardial Infarction for In-Hospital and 360-Day Mortality in Japanese Patients

Cited by 38 publications

References 19 publications

Modified Shock Index is a Predictor for 7-Day Outcomes in Patients With STEMI

Modified Shock Index is a Predictor for 7-Day Outcomes in Patients With STEMI

Shock Index as a Predictor of Myocardial Damage and Clinical Outcome in ST-Elevation Myocardial Infarction

Platelet-to-Lymphocyte Ratio Improves the Predictive Power of GRACE Risk Score for Long-Term Cardiovascular Events in Patients with Acute Coronary Syndrome

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