Diagnostic Accuracy of Hepatic Vein Resistive Index in Detection of Hepatic Fibrosis in Patients of Chronic Liver Disease

Nadeem, Sidrah; Wasim, Sana; Manzoor, Sidrah; Ata, Hareem; Raja, Riffat; Arooj, Sadaf

doi:10.37939/jrmc.v24i3.1482

Cited by 3 publications

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“…In our study, the majority of the population were males which is in line with the previous studies done by Selvamuthukumaran and Kanitkar et al [ 9 , 17 ]. The mean age of the study participants in our study was consistent with the findings of Nadeem et al and Kanitkar et al [ 17 , 18 ]. The bleeding, shock, organ dysfunction, and respiratory distress in severe dengue subjects were in line with the observations of a study by Diwakar and Madhu [ 19 ].…”

Section: Discussionsupporting

confidence: 92%

“…In corroboration to our result, Petchiappan et al [ 21 ] reported a direct association between hyperferritinemia and severe dengue, with a rise in serum ferritin levels starting on day four of illness. In a study conducted by Nadeem et al, patients with severe dengue fever exhibited significantly higher mean serum ferritin levels of 317.54±109.52 ng/mL, than patients with uncomplicated dengue fever (168.69±130.7 ng/mL) [ 18 ]. Similar observations were also made by Kanitkar et al [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

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Role of Serum Ferritin as a Predictor of Dengue Severity: A Prospective Observational Study From India

Goyal,

Hissaria,

Shekhawat

2024

Cureus

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Background: Early detection of dengue fever progression to severe form using simple measurable tests is crucial for initiating appropriate supportive therapy. This study aimed to assess whether serum ferritin is an indicator of severity in dengue patients. Material and methods: This hospital-based prospective observational study was done on 70 patients admitted in wards and intensive care unit (ICU) of Aditya Birla Memorial Hospital, Pune, India, and Jaipur Golden Hospital, Delhi, India, satisfying inclusion criteria during the study period. Dengue cases were classified as those who had non-structural protein 1 (NS1) positivity on days 2-8 and/or positive immunoglobulin M (IgM) on days 6-10, while those with other confirmed diagnoses were considered as other febrile illnesses. The outcome of this study was to see an association between serum ferritin levels and severity of illness, condition at the time of discharge/death, and the length of hospitalization. Results: Mean serum ferritin (ng/mL), platelet count (cells/mm 3 ), and hospital stay (in days) were 1469.43±297.53, 17289.29±8254.47, and 6.01±3.90, respectively. Subjects with severe dengue had significantly higher mean serum ferritin levels and median hospital stays compared to those with non-severe dengue (p<0.05). A moderate (Pearson correlation coefficient ρ=-0.35, p=0.0027) negative correlation was found between serum ferritin level and platelet count whereas a moderate (ρ=0.50, p=0.0000) positive correlation was found between serum ferritin level and hospital stay. Conclusion: Serum ferritin levels can be used as a tool to help differentiate between severe and non-severe dengue.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Role of Serum Ferritin as a Predictor of Dengue Severity: A Prospective Observational Study From India

Goyal,

Hissaria,

Shekhawat

2024

Cureus

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“…Similar result was also seen in the paper on dengue infection in the Aruba Islands by Brazilian and the Dutch medical researcher for rise in SGOT and SGPT [9] . Nadeem et al 2016 [8] , showed hyper ferritinaemia in dengue fever indicates highly active disease resulting in immune activation. There occur reactive hepatitis and ischemic insult to hepatic cell in dengue shock syndrome, which causes rise in liver enzymes.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of hyperferritinemia in dengue: A tertiary health care centre study

Patro¹,

Behera²,

Sahu³

et al. 2021

Int. J. Adv. Res. Med.

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Background: Dengue infection is a major public health threat; early recognition is crucial to improve the survival in severe dengue. For prediction of dengue, various biomarkers are present but they are rarely used. We used serum ferritin to predict the severity at an earlier stage. Methods: This is a prospective observational study conducted in a tertiary health care centre involving 200 dengue cases diagnosed by positive NS1 antigen by ELISA. Serum ferritin was measured in all at the time of diagnosis, day 3 and day 7. We monitored the patients both clinically and biochemically daily and classified them as severe and non-severe according to 2009 WHO criteria. Results: The mean age of the patients was 34.14±12.4 years. Out of 200 patients, 136 (68.0%) patients were male and rest 64 (32.0%) were females, 56 developed severe dengue. All the 200 patients had fever (100%) and arthralgia (100%). Other clinical symptoms like rash, nausea, abdominal pain, persistent vomiting, mucosal bleeding, liver enlargement, clinical fluid accumulation, dengue haemorrhagic fever, dengue shock syndrome, altered sensorium, severe plasma leakage, and patients with ALT more than 1000 U/L was reported in 108 (54.0%), 58 (29.0%), 46 (23.0%), 59 (29.5%), 32 (16.0%), 19 (9.5%), 13 (6.5%), 9 (4.5%), 35 (17.5%), 2 (1%), 12 (6.0%) and 3 (1.5%) patients respectively. The serum ferritin level was correlated with patients having rash, abdominal pain and persisting vomiting both on day 3 and day 7. A negative correlation was observed between serum ferritin level and total platelets count both on day 3 (r=-0.2226; p=0.0016) and day 7 (r=-0.3562; p=0.0001). Patients with severe dengue had significantly low platelet count and higher ferritin levels. Conclusions: Elevated serum ferritin levels can be used as a potential early prognostic marker to predict the severity of dengue infection in clinical practice.

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“…However, estimation of such prognostic markers should require less technical expertise, be cost‐effective, and be able to provide an accurate prediction at an early time point of infection so that appropriate measures can be taken to prevent disease progression. Multiple studies have reported the association of serum ferritin levels with the severity of dengue disease 11,19–42 . Assays for the estimation of serum ferritin are easy to perform and comparatively less expensive, and serum ferritin levels may be considered as a prognostic marker to predict severe dengue.…”

Section: Introductionmentioning

confidence: 99%

Serum ferritin level as a prognostic biomarker for predicting dengue disease severity: A systematic review and meta‐analysis

Shukla

Jadhav

Gurav

et al. 2023

Reviews in Medical Virology

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Serum ferritin levels serves as biomarkers in many inflammatory and infectious diseases. This current systematic review and meta‐analysis evaluated whether serum ferritin levels are associated with severe dengue and its utility as a biomarker of disease severity. Literature searches were conducted in PubMed, Scopus, ScienceDirect, the Cochrane library, and Google Scholar. A total of 18 studies examining the serum ferritin levels in dengue cases in the context of disease severity (nine studies having dengue classification as non‐severe vs. severe dengue cases, and nine studies having dengue classification as dengue without warning signs (DwoWS), dengue with warning signs (DwWS), and severe dengue cases) were included and the quality of the studies was assessed using the Quality in Prognostic Factor Studies tool. The meta‐analysis was performed using STATA software to calculate the effect size as a standardized mean difference (SMD) or Hedges ‘g’ for the continuous outcome. Higher serum ferritin levels were found in severe dengue cases compared to non‐severe cases [SMD (Hedges ‘g’) 4.05 (95% C.I. 2.09–6.00), (I2 = 98.8%)]. In the second group, DwWS cases showed high serum ferritin levels compared to DwoWS [SMD 2.01 (95% C.I. 0.92–3.10), (I2 = 97.89%)], and severe dengue cases showed higher levels of serum ferritin compared to DwWS [SMD 2.66 (95% C.I. 1.72–4.48), (I2 = 98.78%)] and DwoWS cases [SMD 6.65 (95% C.I. 1.72–11.59), (I2 = 99.78%]. Subgroup analysis for the country of study (India vs. others), ferritin testing methods, and ferritin measurement day revealed testing method as a significant contributor to heterogeneity. To conclude, the present study suggests serum ferritin as a prognostic marker for dengue disease severity. Multi‐centric studies involving a large number of dengue patients with a uniform case definition accounting for all the confounding variables might help in determining a universal cut‐off value to discriminate between non‐severe and severe dengue.

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Diagnostic Accuracy of Hepatic Vein Resistive Index in Detection of Hepatic Fibrosis in Patients of Chronic Liver Disease

Cited by 3 publications

References 0 publications

Role of Serum Ferritin as a Predictor of Dengue Severity: A Prospective Observational Study From India

Role of Serum Ferritin as a Predictor of Dengue Severity: A Prospective Observational Study From India

Prognostic significance of hyperferritinemia in dengue: A tertiary health care centre study

Serum ferritin level as a prognostic biomarker for predicting dengue disease severity: A systematic review and meta‐analysis

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