Diagnostic accuracy of imprint cytology and frozen section for CNS tumor

Ahmed, SK Abdul Momen; Badruddoza, Shah Md; Meherunnesa, M; Ekramullah, Sheikh Muhammad; Hossain, Zahed; Habib, Ahsan; Zahan, Rukhsana Akhter

doi:10.3329/fmcj.v9i1.23618

Cited by 4 publications

(6 citation statements)

References 1 publication

(1 reference statement)

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“…Based on our study, there was no significant difference in diagnostic accuracy of cytology smear and frozen section as both techniques revealed comparable and high diagnostic accuracy. Other studies also conclude similar findings (Ahmed et al, 2015;Nanarng et al, 2015;Louis and von Deimling, 2017;Agrawal et al, 2014). This provide an alternative solution to the centres that are lack frozen section facilities and skills.…”

Section: Difference In the Proportion Of Accuracy Between Cytology Smsupporting

confidence: 64%

“…The sample size was calculated using the estimation of sensitivity and specificity sample size calculator by Dr Lin Naing@Mohd Ayub Sadiq from School of Dental Sciences, USM. The estimated sample size to answer the objectives was 48 calculated based on the expected sensitivity and specificity were 100% and 86.21% respectively (Ahmed et al, 2015). This study was approved by the Human Research Ethics Committee, USM with the reference USM/JEPeM/18010083.…”

Section: Case and Sample Selectionmentioning

confidence: 99%

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Evaluation Study of Intraoperative Cytology Smear and Frozen Section of Glioma

Zulkarnain

Yunus

Kandasamy

et al. 2020

Asian Pac J Cancer Prev

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Objective: Glioma is the commonest primary malignant brain tumour. Diagnosis is made based on cytology smear, frozen section and histopathological examination. Intraoperative pathological diagnosis using either cytology smear, frozen section or combination of both, plays a crucial role in patient's future management and prognosis. This study aims to determine the accuracy of cytology smear and frozen section in glioma, and to compare the difference between both techniques. Methods: A cross-sectional study was conducted involving 22 cases of glioma diagnosed intraoperatively from January 2013 until August 2019 in Hospital Universiti Sains Malaysia. The selected tissues were processed for cytology smear and frozen section. The remaining tissues were proceeded for paraffin section. The diagnosis was categorized as either low-grade or high-grade glioma based on cellularity, nuclear pleomorphism, mitotic count, microvascular proliferation and necrosis. The sensitivity and specificity of frozen section and cytology smears were determined based on paraffin section being as the gold standard. The accuracy of both techniques was compared using statistical analysis. Results: The overall sensitivity and specificity of cytology smear were 100% and 76.9%, respectively. Meanwhile, the sensitivity and specificity of frozen section were 100% and 84.6%. There was no significant difference in diagnostic accuracy between cytology smear and frozen section in glioma (p>0.05). Conclusion: Cytology smears provides an alternative method for frozen section due to good cellularity and morphology on smear. Cytology smear is rapid, inexpensive, small amount of tissue requirement and less technical demand. This finding may benefit to the hospital or treatment centres where frozen section facility is unavailable.

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Section: Difference In the Proportion Of Accuracy Between Cytology Smsupporting

confidence: 64%

Section: Case and Sample Selectionmentioning

confidence: 99%

Evaluation Study of Intraoperative Cytology Smear and Frozen Section of Glioma

Zulkarnain

Yunus

Kandasamy

et al. 2020

Asian Pac J Cancer Prev

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“…20 Our 3.31% false-negative results agree with those reported elsewhere. 18,19,[21][22][23][24] Studies have shown that pathologists using IC obtain a high diagnostic accuracy which rivals that of FS, ranging from 60% to100%, depending on the specimen type. 1,4,5,13,25 Our findings of 91.6% sensitivity, 97.7% specificity, 94.1% PPV, and 96.7% NPV support the notion that IC is highly accurate in the evaluation of primary or metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative cytology when cryostat is not available. A 7‐year experience in a Peruvian cancer center

Abad-Licham

Astigueta

Casas

et al. 2022

Diagnostic Cytopathology

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Background: Intraoperative cytology (IC) is an alternative to frozen-section (FS) diagnosis. We present our experience with and the diagnostic value of IC during a 7-year period when FS was not available in a Peruvian Cancer Center.Material and Methods: This 7-year retrospective single-arm review study includes IC procedures performed by three pathologists between 2012 and 2018. These IC reports were reviewed independently by one pathologist and were correlated with the histologic diagnoses, which were used as the gold standard. All IC preparations (imprint, scrape, and crush smears) were stained with hematoxylin and eosin. IC interpretations were categorized as: malignant, benign, atypical, and "deferred to permanent sections." Sensitivity, specificity, and positive and negative predictive values were calculated by use of standard methods.Results: A total of 1814 IC cases prepared from various organs obtained from 887 patients were reviewed. Malignant, benign, atypical, and "deferred to permanent sections" IC diagnoses were 26.3%, 68.9%, 3.7%, and 1.9%, respectively. Atypical and deferred cases were excluded from the statistical analysis; thus 1712 cases were found to be eligible. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall diagnostic accuracy were 91.6%, 97.7%, 94.1%, 96.7%, and 96%, respectively. Conclusion:In experienced hands, IC is a rapid, cost-effective, and accurate alternative diagnostic modality for intraoperative diagnosis when FS is not available.

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“…In our study, all the six CNS cases were accurately diagnosed by frozen section and imprint cytology. SAM Ahmed et al, [25] studied 33 clinically diagnosed patients of CNS tumours, and the sensitivity of frozen section was 100% and that of imprint cytology was 75%. The accuracy of both the techniques in our study were comparable to this study.…”

Section: Discussionmentioning

confidence: 99%

Role of Imprint Cytology in Diagnosis and Assessment of Surgical Margin Clearance of Tumours Compared to Frozen Section

MT¹,

SS²,

CS³

et al. 2022

Glob Acad J Med Sci

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Introduction: Touch imprint cytology is an economical, simple and quick intraoperative diagnostic procedure with good cytological clarity but cannot provide information on the depth of invasion. Frozen section is the standard method but is limited by its cost, need of qualified technical staff and the freezing arte facts. Thus, both the techniques have their own limitations and the combination of these two methods helps in achieving high diagnostic accuracy rates. Objectives: To assess the combined role of imprint cytology and frozen section in the diagnosis of tumours and surgical margin clearance of various organs and to compare the diagnostic accuracy of imprint cytology to frozen section individually verified by subsequent histopathological examination. Material and Methods: The present study was done in the pathology department of Dhaka Medical College Hospital for a period of one year. A total of 72 surgical specimens from various organs were received for imprint cytology and frozen section. The results of both the techniques were verified by the subsequent histopathological diagnosis as “gold standard’’. Results: Out of 72 cases, majority were ovarian neoplasms comprising of 29(40.3%) cases followed by soft tissue tumours (16.7%), breast (9.7%) and brain (8.3%) neoplasms. The majority of the cases were malignant (70.83% including metastatic) followed by benign (20.83%), and borderline (8.33%). The overall diagnostic accuracy of imprint cytology and frozen section in various organs were 95.8% and 97.2% respectively. The combined diagnostic accuracy was 98.6%. The combined accuracy of surgical margin clearance in epithelial tumours was 91.66% and it was higher than the accuracy of 66.66% in non-epithelial tumours. Conclusion: The combination of imprint cytology and frozen section helps in achieving high diagnostic accuracy rates in distinguishing benign and malignant lesions and the accuracy rate for assessment of surgical margin clearance is higher in epithelial neoplasms than that in non-epithelial neoplasms in intraoperative diagnosis.

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Diagnostic accuracy of imprint cytology and frozen section for CNS tumor

Cited by 4 publications

References 1 publication

Evaluation Study of Intraoperative Cytology Smear and Frozen Section of Glioma

Evaluation Study of Intraoperative Cytology Smear and Frozen Section of Glioma

Intraoperative cytology when cryostat is not available. A 7‐year experience in a Peruvian cancer center

Role of Imprint Cytology in Diagnosis and Assessment of Surgical Margin Clearance of Tumours Compared to Frozen Section

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