Diagnostic accuracy of interleukin-6 levels in peritoneal fluid for detection of endometriosis

Wickiewicz, Dorota; Chrobak, Agnieszka; Gmyrek, Grzegorz B.; Halbersztadt, Alicja; Gabryś, Marian; Goluda, M; Chełmońska-Soyta, Anna

doi:10.1007/s00404-013-2828-6

Cited by 36 publications

(24 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Analysis of the concentrations of these cytokines showed differential diagnostic usefulness for endometriosis. Peritoneal concentrations of IL-6 offer relatively good diagnostic accuracy [37]. At the same time, a very recent study has shown that at the cut-off value of 3.00 pg/ml peritoneal TNF-α can be a reliable screening marker for the prediction of endometriosis in adolescents [38].…”

Section: Discussionmentioning

confidence: 99%

Clinical immunology Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Măluţan¹,

Drugan²,

Costin³

et al. 2015

cejoi

103

View full text Add to dashboard Cite

The aim of the studyThe aim of the study was to investigate the serum pro-inflammatory cytokine profile in patients with diagnosed endometriosis.Material and methodsThe study included 160 women, who were divided in two study groups (Group I – endometriosis; Group 2 – healthy). We evaluated the serum levels of interleukin (IL)-1β, IL-5, IL-6, IL-7, and IL-12, and of tumour necrosis factor α (TNF-α) with the use of Human Multiplex Cytokine Panels.ResultsThe serum level of IL-1β, IL-6, and TNF-α is significantly higher in women with endometriosis compared to women free of disease, from the control group (mean 10.777, 183.027, and 131.326, respectively, compared to 3.039, 70.043, and 75.285, respectively; p = 0.002, p < 0.001, and p = 0.015, respectively). No significant differences in the serum levels of IL-5 and IL-12 were observed between the studied groups, and IL-7 had a very low detection rate.ConclusionsWomen with endometriosis have elevated levels of key pro-inflammatory cytokines, i.e. IL-1β, IL-6, and TNF-α. At the same time, IL-1β and IL-6 could be used as predictors for endometriosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical immunology Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Măluţan¹,

Drugan²,

Costin³

et al. 2015

cejoi

103

View full text Add to dashboard Cite

show abstract

“…Ghrelin levels were increased in peritoneal fluid of patients with endometriosis, and positively correlated with vascular endothelial growth factor (VEGF) [6]. Further, interleukin-6 (IL-6) and VEGF might contribute towards development of the ectopic endometrial implants [7,8]. Therefore, it is apparent that patients with endometriosis have an active inflammatory environment in peritoneal cavity, which is possibly responsible for the pain associated with endometriosis [9].…”

Section: Introductionmentioning

confidence: 96%

Distinct peritoneal fluid ghrelin and leptin in infertile women with endometriosis and their correlation with interleukin-6 and vascular endothelial growth factor

Rathore¹,

Kriplani

Yadav³

et al. 2014

Gynecological Endocrinology

View full text Add to dashboard Cite

show abstract

“…3 Afferent sensory fibers and proinflammatory mediators are correlated with endometriosis pain, which can be considered an inflammatory neuropathic pain. [4][5][6][7][8][9][10][11] However, excision of endometriotic lesions and/or anti-inflammatory drugs cannot relieve pain symptoms completely. What is more, a high probability of recurrence and serious side effects might occur, 1,[12][13][14][15] thereby leading to the dilemma in its clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain

Yuan

Ding

Meng

et al. 2017

IJN

View full text Add to dashboard Cite

Endometriosis is a common gynecological disease with a lack of effective clinical treatment. Current therapy often results in endometriosis pain recurrence and serious side effects. P2X 3 receptor, an adenosine triphosphate (ATP)-gated ion channel, might be implicated in endometriosis pain. In this study, chitosan oligosaccharide-g-stearic acid (CSOSA) polymer micelles-coated nanostructured lipid carriers (NLCs) were developed as a novel delivery system for A-317491, a selective P2X 3 receptor antagonist for endometriosis pain therapy. A-317491-loaded NLC (NLC/A-317491) could be coated by CSOSA micelles to form CSOSA/NLC/A-317491 nanoparticles. Pheochromocytoma PC12 cells, which highly expressed P2X 3 receptors, were used as a cell model, and the CSOSA/NLC/A-317491 partly blocked the Ca 2+ influx induced by ATP stimulation. In nude mouse and rat endometriotic models, CSOSA/NLC could accumulate into endometriotic lesions after vein injection. In endometriotic rats, CSOSA/NLC/A-317491 reversed mechanical and heat hyperalgesia with long-term efficacy, which might be attributed to the massive CSOSA/NLC/A-317491 distribution in the endometriotic lesions. In conclusion, A-317491 delivered by CSOSA/NLC nanoparticles attenuated endometriosis pain in rats, and CSOSA/NLC/A-317491 could be used as an effective treatment strategy for P2X 3 -targeted therapy in endometriosis pain.

show abstract

Diagnostic accuracy of interleukin-6 levels in peritoneal fluid for detection of endometriosis

Cited by 36 publications

References 48 publications

Clinical immunology Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Clinical immunology Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Distinct peritoneal fluid ghrelin and leptin in infertile women with endometriosis and their correlation with interleukin-6 and vascular endothelial growth factor

Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain

Contact Info

Product

Resources

About