Diagnostic accuracy of mean platelet volume in thromboangiitis obliterans

Abstract

Thromboangiitis obliterans (TAO) affects small- and medium-sized vessels of the extremities via a non-atherosclerotic inflammatory process in the elderly. Although diagnostic criteria have been determined, only a few studies have been described in the laboratory features. Diagnostic biomarkers are important for reducing disruptions caused by TAO. The diagnostic importance of mean platelet volume (MPV) was investigated in TAO patients. Forty-four patients diagnosed with TAO (study group) and 45 healthy individuals (control group) were included in the study. The age, gender and complete blood parameters obtained via peripheral venous blood samples were compared between the two groups. A receiver operating characteristic (ROC) curve was used for determining the diagnostic accuracy of the MPV variable. All the variables were statistically similar in each group except MPV and platelet counts. MPV was significantly higher and platelet count was significantly lower in the TAO group (P< 0.05). In addition, diagnostic accuracy was measured by the area under the ROC curve (Figure 1), and MPV differs significantly (P< 0.001), with a value of 0.783 (95% CI: 0.711-0.854). This study indicates that MPV is probably an important diagnostic predictor in TAO patients. Detection of blood parameters such as platelet properties is important for meticulous care of these patients.

The relationship between complete blood count parameters and Fontaine’s Stages in patients with peripheral arterial disease

“…21 On the other hand, some of the complete blood counting parameters reactivity are also shown in atherosclerotic events such as high platelet reactivity is associated with increases in both atherosclerosis burden and plaque calcification in previous reports. 12,22 In the view of these correlations, our results supported that increased bone marrow reactivity may play a role in progression of disease. According to our results, high plasma RDW and MPV levels can be sourced by increased bone marrow reactivity and this process should be investigated with further clinical researches.…”

“…MPV has been suggested to be a guide to identify high-risk patients with disturbed microcirculation related disease in previous reports. 15 In another study reported by Yavuz et al., 12 the authors argued that higher MPV levels might be a predictor of disrupted peripheral circulation. The results of this study correlates similarly with to our study, diverging with PAD population being thromboangiitis obliterans patients.…”

“…This distorted heterogeneous distribution of megakaryocytes might be a predictor of various disorders. 12 Chu et al 13 reported that MPV elevations might be an indicator of increased cardiovascular risk. Moreover, Berger et al 14 concluded that MPV is an independent indicator of PAD.…”

Association of mean platelet volume with impaired myocardial reperfusion and short-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

“…Increased MPV has been reported to correlate with intracoronary thrombus burden in the IRA before mechanical reperfusion, in-hospital major adverse cardiovascular events in patients with STEMI undergoing PCI [7,8], and 1-year incidence of death or myocardial infarction in patients with acute coronary syndrome undergoing PCI [9]. Furthermore, recent studies by Demirtas et al [10] and Yavuz et al [11] showed there is an interaction between MPV and disease severity in many types of arterial-occlusive diseases, such as peripheral artery disease and thromboangiitis obliterans. However, the association between MPV and myocardial reperfusion in patients with STEMI and successful epicardial reperfusion after PCI has not been fully investigated.…”

The Association of Flow-Mediated Dilatation and Blood Parameters in Primary Raynaud’s Phenomenon

“…Moreover, it has been emphasized that these parameters may be predictive in vascular diseases. While MPV values are predicted to have a diagnostic predictive value in patients with thromboangiitis obliterans involving the distal vascular bed, which is a disease very similar to RP, on the other hand, NLR values were also found to be associated with intima-media thickness in patients with Behcet's disease [ 9 , 10 ]. In addition, monocyte chemoattractant protein-1 (MCP-1) is a serum inflammation parameter that has been investigated in similar conditions and it has been less studied in vascular system diseases compared to other parameters [ 11 ].…”