Diagnostic Accuracy of Multi-Parametric Magnetic Resonance Imaging for Tumor Staging of Bladder Cancer: Meta-Analysis

Zhang, Nieke; Wang, Xiaoyan; Wang, Qianqian; Chen, Shuqiu; Wu, Jianping; Zhang, Guangyuan; Zhu, Weidong; Liu, Jing; Xu, Bin; Du, Mulong; Chen, Ming

doi:10.3389/fonc.2019.00981

Cited by 15 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiparametric magnetic resonance imaging (mp-MRI) has recently become an emerging method for the BC local staging and, in particular, for the detection of MIBC [7][8][9]. In this context, the Vesical Imaging-Reporting and Data System (VI-RADS), introduced in 2018, represents a standardized reporting criterion for bladder MRI aiming to improve the communication among doctors, thus potentially improving patient management [8].…”

Section: Introductionmentioning

confidence: 99%

Bladder cancer: do we need contrast injection for MRI assessment of muscle invasion? A prospective multi-reader VI-RADS approach

et al. 2020

View full text Add to dashboard Cite

Objectives (1) To investigate whether a contrast-free biparametric MRI (bp-MRI) including T2-weighted images (T2W) and diffusion-weighted images (DWI) can be considered an accurate alternative to the standard multiparametric MRI (mp-MRI), consisting of T2, DWI, and dynamic contrast-enhanced (DCE) imaging for the muscle-invasiveness assessment of bladder cancer (BC), and (2) to evaluate how the diagnostic performance of differently experienced readers is affected according to the type of MRI protocol. Methods Thirty-eight patients who underwent a clinically indicated bladder mp-MRI on a 3-T scanner were prospectively enrolled. Trans-urethral resection of bladder was the gold standard. Two sets of images, set 1 (bp-MRI) and set 2 (mp-MRI), were independently reviewed by four readers. Descriptive statistics, including sensitivity and specificity, were calculated for each reader. Receiver operating characteristic (ROC) analysis was performed, and the areas under the curve (AUCs) were calculated for the bp-MRI and the standard mp-MRI. Pairwise comparison of the ROC curves was performed. Results The AUCs for bp- and mp-MRI were respectively 0.91–0.92 (reader 1), 0.90 (reader 2), 0.95–0.90 (reader 3), and 0.90–0.87 (reader 4). Sensitivity was 100% for both protocols and specificity ranged between 79.31 and 89.66% and between 79.31 and 83.33% for bp-MRI and mp-MRI, respectively. No significant differences were shown between the two MRI protocols (p > 0.05). No significant differences were shown accordingly to the reader’s experience (p > 0.05). Conclusions A bp-MRI protocol consisting of T2W and DWI has comparable diagnostic accuracy to the standard mp-MRI protocol for the detection of muscle-invasive bladder cancer. The experience of the reader does not significantly affect the diagnostic performance using VI-RADS. Key Points • The contrast-free MRI protocol shows a comparable accuracy to the standard multiparametric MRI protocol in the bladder cancer muscle-invasiveness assessment. • VI-RADS classification helps non-expert radiologists to assess the muscle-invasiveness of bladder cancer. • DCE should be carefully interpreted by less experienced readers due to inflammatory changes representing a potential pitfall.

show abstract

Section: Introductionmentioning

confidence: 99%

Bladder cancer: do we need contrast injection for MRI assessment of muscle invasion? A prospective multi-reader VI-RADS approach

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Aided by medical imaging studies such as ultrasound, computed tomography and magnetic resonance imaging (MRI), differential diagnoses can be narrowed, bladder lesions can be further characterised and metastases can be evaluated. Of these imaging modalities, only MRI provides the best tissue contrast for differentiating MIBC from NMIBC 6–9 . However, the use of bladder MRI in the diagnostic workup before surgical treatment has been limited due to non‐standardised magnetic resonance image acquisition and reporting.…”

Section: Introductionmentioning

confidence: 99%

“…Of these imaging modalities, only MRI provides the best tissue contrast for differentiating MIBC from NMIBC. [6][7][8][9] However, the use of bladder MRI in the diagnostic workup before surgical treatment has been limited due to nonstandardised magnetic resonance image acquisition and reporting. Recently, the Vesical Imaging-Reporting and Data System (VIRADS) was developed to unify these standards.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of the Vesical Imaging–Reporting and Data System (VIRADS) for pre‐treatment staging of bladder cancer in an Australian cohort

et al. 2021

View full text Add to dashboard Cite

Introduction: To evaluate the performance of the Vesical Imaging-Reporting and Data System (VIRADS) in differentiating muscle-invasive and nonmuscle-invasive bladder cancer and whether this reporting system improves inter-reader agreement. Methods: Sixty-four cases of multiparametric 3 tesla bladder MRI from January 2014 to May 2020 were reviewed retrospectively. T2-weighted, diffusion and post-contrast images were reviewed. All magnetic resonance images were reported by a radiologist with 15 years' experience (Reader 1) and a final year radiology trainee with a special interest in urogenital imaging with 3 years of experience (Reader 2). Both readers were blinded to clinical history and histopathology results when scoring each lesion. Results: The sensitivity and specificity for differentiating MIBC and NMIBC were 91% and 68%, respectively, for Reader 1 and 91% and 63%, respectively, for Reader 2. The inter-reader agreement for assigning VIRADS scores was 0.79. The area under the receiver operator curve for Reader 1 and 2 were not significantly different (Reader 1 = 0.79, Reader 2 = 0.77, P = 0.83). Conclusions: Staging of bladder cancer prior to treatment can be accurately and reliably diagnosed using VIRADS, a novel, standardised reporting system for bladder MRI.

show abstract

“… 46 , 47 Compared with CT, multiparametric MRI (mpMRI) has a high diagnostic value in differentiating the absence or presence of DM invasion in patients, and then distinguishing muscle invasive BC (MIBC) from NMIBC through the Vesical Imaging-Reporting and Data System (VI-RADS). 48 , 49 , 50 However, MRI is more time-consuming and not suitable for patients who have a medical history of metal foreign body implantation. PET/CT is the combination of function-based PET imaging and anatomy-based CT imaging that is mainly used in the detection of metastatic disease and positive lymph nodes with normal size.…”

Section: Main Textmentioning

confidence: 99%

Endoscopic Molecular Imaging plus Photoimmunotherapy: A New Strategy for Monitoring and Treatment of Bladder Cancer

Yang

Liu

Yang

2020

Molecular Therapy - Oncolytics

View full text Add to dashboard Cite

Due to the high recurrence and progression rate of non-muscle invasive bladder cancer after transurethral resection of bladder tumor, some new optical imaging technologies have arisen as auxiliary imaging modes for white light cystoscopy to improve the detection rate of small or occult tumor lesions, such as photodynamic diagnosis, narrow-band imaging, and molecular imaging. White light cystoscopy is inadequate and imperfect for bladder cancer detection, and thus residual tumors or coexisting flat malignant lesions, especially carcinoma in situ , would be ignored during conventional resection. The bladder, a hollow organ with high compliance, provides an ideal closed operation darkroom for endoscopic molecular imaging free from interference of external light sources. Also, intravesical instillation of a molecular fluorescent tracer is simple and convenient before surgery through the urethra. Molecular fluorescent tracer has high sensitivity and specificity to tumor cells, and its mediated molecular imaging allows small or occult tumor lesion detection while minimizing false-positive results. Meanwhile, endoscopic molecular imaging provides a real-time and dynamic image during surgery, which helps urologists to perform high-quality and complete tumor resection through accurate judgment of tumor boundaries and depth of invasion. Photoimmunotherapy is a novel molecular targeted therapeutic pattern of photodynamic therapy that kills malignant cells selectively and minimizes the cytotoxicity to normal tissues. The combination of endoscopic molecular imaging and photoimmunotherapy used in initial treatment may avoid the need of repeat transurethral resection in strictly selected patients and improve oncological outcomes such as recurrence-free survival and overall survival after operation.

show abstract

Diagnostic Accuracy of Multi-Parametric Magnetic Resonance Imaging for Tumor Staging of Bladder Cancer: Meta-Analysis

Cited by 15 publications

References 23 publications

Bladder cancer: do we need contrast injection for MRI assessment of muscle invasion? A prospective multi-reader VI-RADS approach

Bladder cancer: do we need contrast injection for MRI assessment of muscle invasion? A prospective multi-reader VI-RADS approach

Accuracy of the Vesical Imaging–Reporting and Data System (VIRADS) for pre‐treatment staging of bladder cancer in an Australian cohort

Endoscopic Molecular Imaging plus Photoimmunotherapy: A New Strategy for Monitoring and Treatment of Bladder Cancer

Contact Info

Product

Resources

About